Antibacterial promoting healing foam dressing, preparation method thereof and application

A technology of foam and foam stabilizer, which is applied in the field of medicine, can solve problems such as poor stability, inconvenient use, and failure to meet the requirements of use, and achieve the effects of fast wound healing, excellent anti-inflammatory, and inhibition of bacterial growth and reproduction

Active Publication Date: 2019-01-22
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, liquid dressings are usually in a liquid state, have poor stability, are inconvenient to use, and cannot meet people's use requirements.

Method used

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  • Antibacterial promoting healing foam dressing, preparation method thereof and application
  • Antibacterial promoting healing foam dressing, preparation method thereof and application
  • Antibacterial promoting healing foam dressing, preparation method thereof and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The foam dressing is prepared from the following raw materials in parts by weight:

[0058] Calcium alginate 15 parts, sodium alginate 10 parts, methyl gluceth-10 10 parts, urea 40 parts, windproof extract 12 parts, toluene diisocyanate 15 parts, polyether propylene glycol 4 parts, polyether glycerine 4 parts of alcohol, 1 part of stannous octoate, 1 part of dibutyltin, 2 parts of silicone foam stabilizer, 1 part of tetrahydrofuran, 1 part of petroleum ether and 150 parts of water.

[0059] Preparation:

[0060] (1) Calcium alginate, sodium alginate, methyl gluceth-10, urea, toluene diisocyanate, polyether propylene glycol, polyether glycerin, stannous octoate, dibutyltin, silicone Mix foam stabilizer, tetrahydrofuran, petroleum ether and water, and stir for 5 minutes at 25°C;

[0061] (2) Add the windproof extract according to the formula, stir for 3 minutes, place in a foaming mold, keep warm at 60° C. for 15 minutes, remove the mold and cut to obtain the foam dress...

Embodiment 2

[0063] The foam dressing is prepared from the following raw materials in parts by weight:

[0064] Calcium alginate 20 parts, methyl gluceth-10 25 parts, urea 30 parts, parsnip extract 15 parts, toluene diisocyanate 10 parts, polyether propylene glycol 10 parts, triethanolamine 1 part, silicone foam stabilizer 1 part, 1 part tetrahydrofuran, 1 part petroleum ether, 1 part trichlorofluoromethane, 2 parts dichlorotetrafluoroethane and 100 parts water.

[0065] Preparation:

[0066] (1) Calcium alginate, methyl gluceth-10, urea, toluene diisocyanate, polyether propylene glycol, triethanolamine, silicone foam stabilizer, tetrahydrofuran, petroleum ether, trichlorofluoromethane, Dichlorotetrafluoroethane and water were mixed and stirred at 20°C for 10 minutes;

[0067] (2) Add the windproof extract according to the formula, stir for 1 minute, place in a foaming mold, keep warm at 65° C. for 10 minutes, remove the mold and cut to obtain the foam dressing.

Embodiment 3

[0069] The foam dressing is prepared from the following raw materials in parts by weight:

[0070] 30 parts of sodium alginate, 5 parts of methyl gluceth-10, 50 parts of urea, 10 parts of windproof extract, 20 parts of toluene diisocyanate, 5 parts of polyether glycerol, 1 part of stannous octoate, dibutyltin 1 part, 1 part of triethanolamine, 1 part of triethylenediamine, 1 part of triethylamine, 5 parts of silicone foam stabilizer, 1 part of tetrahydrofuran and 200 parts of water.

[0071] Preparation:

[0072] (1) Sodium alginate, methyl gluceth-10, urea, toluene diisocyanate, polyether glycerol, stannous octoate, dibutyltin, triethanolamine, triethylenediamine, triethyl Mix amine, silicone foam stabilizer, tetrahydrofuran and water, and stir at 30°C for 1 min;

[0073] (2) Add the windproof extract according to the formula, stir for 5 minutes, place in a foaming mold, keep warm at 55° C. for 20 minutes, remove the mold and cut to obtain the foam dressing.

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Abstract

The invention provides an antibacterial promoting healing foam dressing, a preparation method thereof and application. The antibacterial promoting healing foam dressing is mainly prepared from the following raw materials: alginate, methyl gluconol polyether-10, urea, and parsnip extract. According to the antibacterial promoting healing foam dressing, the alginate and the parsnip extract in the foam dressing are acted synergistically to inhibit bacterial growth and reproduction, matched with the methyl gluconol polyether-10 and the urea, a sterile wet micro-environment is provided for wound surface to facilitate healing of a wound, and the effects of hemostasis, anti-inflammatory, promoting healing and bacteriostasis are excellent.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a foam dressing for antibacterial and healing promotion and its preparation method and application. Background technique [0002] Traditional wound dressings include dry gauze and oiled gauze. Dry gauze is used to cover the wound, but its ability to manage exudate is limited. Adhesive wounds may cause re-injury of new epithelial tissue; oil gauze dressings contain petroleum jelly or triglycerides to avoid wound adhesions , but the ability to promote wound healing is poor. Because the liquid secreted by the wound cannot pass through the adhesive plaster layer, traditional wound dressings are likely to cause local skin soaking, making the wound and surrounding skin whiten or even rot. Modern wound dressings avoid the disadvantages of traditional wound dressings to a large extent, not only can protect the wound comprehensively, but also can promote wound healing. [0003] CN 103263...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0023A61L26/0057A61L26/0066A61L26/0085A61L2300/236A61L2300/30A61L2300/404A61L2300/41A61L2300/412A61L2300/418C08L5/04
Inventor 车七石刘少辉李新霞
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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