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A drug delivery controlled release system with tumor triggering and targeting ability and preparation method thereof

A targeted and capable technology, applied in the field of drug delivery controlled release system with tumor-inducing targeting ability, can solve the problem that the drug-loading system cannot accurately target tumor cells, the evaluation of the carrier system is inaccurate, and clinical trials are difficult To achieve excellent biocompatibility, promote cell uptake, and high drug loading

Active Publication Date: 2021-04-30
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] (2) The research on the nanodiamond / hollow mesoporous silicon drug carrier system belongs to bioengineering. This research is subject to objective conditions, and clinical trials are difficult to carry out in a short period of time. These results cannot fully and truly reflect the situation of human trials, so give Evaluating carrier systems introduces a lot of inaccuracies
[0010] (3) Due to the complexity of the human body, the drug delivery system cannot accurately target tumor cells

Method used

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  • A drug delivery controlled release system with tumor triggering and targeting ability and preparation method thereof
  • A drug delivery controlled release system with tumor triggering and targeting ability and preparation method thereof
  • A drug delivery controlled release system with tumor triggering and targeting ability and preparation method thereof

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Embodiment 1

[0062] 1. Preparation of mercapto-functionalized hollow mesoporous silicon HMSN-SH

[0063] Add 10ml of ammonia water (25%) and 10ml of tetraethyl orthosilicate (TEOS) to the mixed solution containing 60ml of deionized water and 428ml of ethanol in turn, stir at 30°C for 2h, wash and centrifuge twice with ethanol and deionized water , lyophilized to obtain SiO 2 .

[0064] 200mg SiO2 was fully dispersed in 40ml deionized water, and then the suspension was added to a mixture containing 300mg CTAB (60ml deionized water, 60ml ethanol, and 1.1ml ammonia water). The mixture was stirred at 35°C, and after 0.5h, 0.3ml TEOS Add quickly, react for 6 hours and collect by centrifugation, and the product is dispersed in 40ml deionized water to obtain SSiO 2 CTAB / SiO2 2 suspension;

[0065] Under vigorous stirring, 848 mg Na2CO3 was added to the SSiO 2 CTAB / SiO2 2 The suspension was stirred at 50°C for 12 hours, washed with ethanol and water, centrifuged and freeze-dried.

[0066] S...

Embodiment 2

[0087] 1. Preparation of mercapto-functionalized hollow mesoporous silicon HMSN-SH

[0088] Add 10ml of ammonia water (28%) and 10ml of tetraethyl orthosilicate (TEOS) to the mixed solution containing 60ml of deionized water and 450ml of ethanol in turn, stir at 30°C for 2h, wash and centrifuge twice with ethanol and deionized water , lyophilized to obtain SiO 2 .

[0089] 200mg SiO2 was fully dispersed in 40ml deionized water, and then the suspension was added to a mixture containing 300mg CTAB (60ml deionized water, 60ml ethanol, and 1.1ml ammonia water). The mixture was stirred at 35°C, and after 0.5h, 0.3ml TEOS Add quickly, after reacting for 6h and collect by centrifugation, the product is dispersed in 40ml deionized water to obtain SSiO 2 CTAB / SiO2 2 suspension;

[0090] Under vigorous stirring, 848 mg Na2CO3 was added to the SSiO 2 CTAB / SiO2 2 in the suspension, stirred at 50°C for 12 hours, washed with ethanol and water, centrifuged and freeze-dried;

[0091] S...

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Abstract

The present invention relates to a drug-carrying controlled-release system capable of initiating and targeting tumors and a specific preparation method thereof. The controlled-release system has a three-layer core-shell structure, and the inner layer is a drug-loaded mesoporous silicon nanoparticle. The drug-loaded The pores of the mesoporous silicon nanoparticles are sealed by activated nano-diamonds, the middle layer is a polylysine layer, and the outer layer is a maleic anhydride polylysine layer; the preparation process includes: preparing mercapto-functionalized hollow mesoporous silicon HMSN‑ Preparation of SH, S‑(2‑aminoethylmercapto)‑2‑mercaptopyridine hydrochloride, disulfide functionalization, drug-loaded nanoparticles, preparation of adamantane-capped polylysine, preparation of maleinized polylysine Amino acid, polylysine layer-by-layer self-assembly modification, maleic anhydride poly-lysine layer-by-layer self-assembly modification; the system has achieved a good "passive targeting" ability, and the delivery has "invisibility". "Passive targeting" enrichment and release of tissue parts, high drug utilization, and less toxic and side effects.

Description

technical field [0001] The invention relates to the field of drug controlled release, in particular to the field of a drug delivery controlled release system with tumor-initiating targeting capability and a specific preparation method thereof. Background technique [0002] In recent years, malignant tumors have become an increasing threat to people's health, and the morbidity and mortality have increased year by year. Although there are many methods and methods for treating tumors, chemotherapy is still the main method for treating tumors. Therefore, constructing a tumor-targeting drug carrier system is the only choice to solve the problem of chemotherapy. At present, among the anticancer drug carrier systems, the organic / polymer carriers represented by liposomes and micelles are the most common. However, the shortcomings of organic / polymer carriers such as low drug loading, poor stability, unsuitable size, and easy aggregation limit their further development among the cur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/04A61K47/34A61K31/704A61P35/00
CPCA61K9/5115A61K9/5146A61K31/704A61P35/00
Inventor 李草陈重银卢金博罗毕矗陈辉万立辉
Owner HUBEI UNIV