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Method for preparing PVCL-based temperature-sensitive composite microgel loaded with MoO3 quantum dots

A technology of microgels and quantum dots, applied in the field of fluorescence imaging, can solve the problem of low synthesis temperature affecting the properties of inorganic nanoparticles, and achieve the effect of good colloidal stability.

Inactive Publication Date: 2019-02-01
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention aims to solve the existing problem that the in-situ synthesis of inorganic nanoparticles using microgel has a low synthesis temperature that affects the synthesis effect and the properties of inorganic nanoparticles; and provides a loaded MoO 3 Preparation method of PVCL-based temperature-sensitive composite microgel of quantum dots

Method used

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  • Method for preparing PVCL-based temperature-sensitive composite microgel loaded with MoO3 quantum dots
  • Method for preparing PVCL-based temperature-sensitive composite microgel loaded with MoO3 quantum dots
  • Method for preparing PVCL-based temperature-sensitive composite microgel loaded with MoO3 quantum dots

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Effect test

specific Embodiment approach 1

[0037] Specific implementation mode 1. This implementation mode loads MoO 3 The preparation method of the PVCL-based temperature-sensitive composite microgel of quantum dots is carried out according to the following steps:

[0038] Step 1, prepare poly-N-vinyl caprolactam (PVCL) microgel according to the following steps:

[0039]Step (1), 0.93g N-vinyl caprolactam (NVCL), 10.5mg methylene bisacrylamide (MBA), 15mg sodium dodecyl sulfate (SDS) and 30mg NaHCO 3 After mixing, add 60 mg of distilled water, stir until dissolved, and then bubble nitrogen for 30 minutes (to remove oxygen);

[0040] Step (2), then heat to 70°C, keep warm and stir at a rate of (please supplement) 500r / min for 30min to make it fully emulsified, then add 30mg of initiator potassium persulfate (KPS), react for 6 hours, and terminate the reaction;

[0041] Step (3), dialyze with a 12000kDa dialysis bag for four days, change the water four times a day, and dry at 50°C (please supplement the temperature) o...

specific Embodiment approach 2

[0044] Specific implementation mode 2. This implementation mode loads MoO 3 The preparation method of the PVCL-based temperature-sensitive composite microgel of quantum dots is carried out according to the following steps:

[0045] Step 1, prepare poly-N-vinyl caprolactam (PVCL) microgel according to the following steps:

[0046] Step (1), 0.93g N-vinyl caprolactam (NVCL), 10.5mg methylene bisacrylamide (MBA), 15mg sodium dodecyl sulfate (SDS) and 30mg NaHCO 3 After mixing, add 60 mg of distilled water, stir until dissolved, and then bubble nitrogen for 30 minutes (to remove oxygen);

[0047] Step (2), then heated to 70°C, kept warm and stirred at a rate of 500r / min for 30min to make it fully emulsified, then added 30mg initiator potassium persulfate (KPS), reacted for 6 hours, and terminated the reaction;

[0048] Step (3), dialysis with a 12000kDa dialysis bag for four days, change the water four times a day, and dry at 50°C (please add temperature) overnight to obtain PVC...

specific Embodiment approach 3

[0051] Specific implementation mode 3. This implementation mode loads MoO 3 The preparation method of the PVCL-based temperature-sensitive composite microgel of quantum dots is carried out according to the following steps:

[0052] Step 1, prepare poly-N-vinyl caprolactam (PVCL) microgel according to the following steps:

[0053] Step (1), 0.92g N-vinyl caprolactam (NVCL), 21.0mg methylene bisacrylamide (MBA), 15mg sodium dodecyl sulfate (SDS) and 30mg NaHCO 3 After mixing, add 60 mg of distilled water, stir until dissolved, and then bubble nitrogen for 30 minutes (to remove oxygen);

[0054] Step (2), then heated to 70°C, kept warm and stirred at a rate of 500r / min for 30min to make it fully emulsified, then added 30mg initiator potassium persulfate (KPS), reacted for 6 hours, and terminated the reaction;

[0055] Step (3), dialysis with a 12000kDa dialysis bag for four days, change the water four times a day, and dry at 50°C (please add temperature) overnight to obtain PVC...

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Abstract

The invention relates to a method for preparing a PVCL-based temperature-sensitive composite microgel loaded with MoO3 quantum dots, which belongs to the field of fluorescence imaging. The method solves the problems that the existing in-situ synthesis of inorganic nanoparticles by using the microgel has low synthesis temperature which affects the synthesis effect and the properties of the inorganic nanoparticles. The method of the invention comprises the following steps: step 1: preparing the PVCL microgel; step 2, adding water to molybdenum disulfide, adding hydrogen peroxide under stirring condition, fully oxidizing the material to a light yellow clear liquid, and then continuing to place the liquid for more than 24 hours to obtain a molybdic acid precursor; and step 3, adding anhydrousethanol to the PVCL microgel obtained in the first step, stirring the material until the material is dissolved, adding distilled water, stirring the material for 30 min, then adding the molybdic acidprecursor obtained in the second step, sealing the material, stirring the material for 1 hour, and then at performing a reaction at 50 DEG C-180 DEG C and then performing dialysis treatment to obtainthe composite microgel solid. The method is applicable to the fields of drug loading, releasing and imaging or chemical or biological sensing.

Description

technical field [0001] The invention belongs to the field of fluorescence imaging; in particular, it relates to a loaded MoO 3 Preparation method of PVCL-based temperature-sensitive composite microgel of quantum dots. Background technique [0002] Inorganic nanoparticles such as semiconductor nanoparticles and noble metal nanoparticles often have excellent photothermal and photoelectric conversion properties, such as photothermal, fluorescent, and magnetic properties. These properties of them allow them to be used in biomedical fields, such as cell imaging, drug targeting, tracking and controlled release, biosensing, nuclear magnetic resonance, etc. However, these inorganic nanoparticles usually have defects such as easy aggregation, biotoxicity, and difficulty in target labeling, which limit their applications in the field of biomedicine. [0003] In the existing in-situ synthesis of inorganic nanoparticles using microgel, there is a problem that the synthesis effect and ...

Claims

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Application Information

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IPC IPC(8): C08L39/04C08K3/22C08J3/075C08F220/38C08F226/06C09K11/02C09K11/68
CPCC08F226/06C08J3/075C08J2339/04C08K2003/2255C09K11/025C09K11/681C08F222/385
Inventor 唐冬雁彭靖高静茹贾舒悦孙赵洁杨旭
Owner HARBIN INST OF TECH
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