Hemostatic sponge and preparation process thereof

A hemostatic sponge and a preparation process technology, applied in the field of medical supplies, can solve the problems of aldehyde cross-linking agent being easy to produce toxicity, lack of solubility, limited antibacterial performance, etc., and achieve strong infection prevention ability, low production cost and low price. Effect

Inactive Publication Date: 2019-02-15
元化科技(嘉兴)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, chitosan has no solubility in neutral aqueous solution, and its foaming performance is poor. It often needs to be dissolved in acidic solution, thereby limiting its antibacterial performance. Chitosan needs to be cross-linked with glutaraldehyde to obtain Hemostatic sponge, these processes are easy to affect the environment, and the residual aldehyde crosslinking agent is easy to produce toxicity

Method used

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  • Hemostatic sponge and preparation process thereof
  • Hemostatic sponge and preparation process thereof

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[0019] The embodiment of the present invention relates to a preparation process of a hemostatic sponge, comprising the following steps:

[0020] S 1 , add carboxymethyl chitosan to deionized water, dissolve completely, obtain carboxymethyl chitosan polymer solution; add chitosan to carboxymethyl chitosan polymer solution, mix evenly, obtain polymer mixture Solution; in parts by weight, chitosan in the polymer mixed solution is 0.1-0.5 parts, carboxymethyl chitosan is 1-5 parts, and deionized water is 10-100 parts;

[0021] S 2 , add 0.1-0.5 parts by weight of green tea extract powder to the polymer mixed solution, mix well, then add glycerin for foaming, place the foamed solution in a 10×10cm plastic petri dish, and then add calcium chloride solution Promote the cross-linking of chitosan and carboxymethyl chitosan to obtain a cross-linked polymer solution;

[0022] S 3 , freeze-dried to obtain a hemostatic sponge, and finally cut into shape.

[0023] In parts by weight, p...

Embodiment 1

[0032] This embodiment relates to a preparation process of a hemostatic sponge, comprising the following steps:

[0033] S 1 , add 5g carboxymethyl chitosan to 100g deionized water, dissolve completely, obtain carboxymethyl chitosan polymer solution; Add 0.5g chitosan in carboxymethyl chitosan polymer solution, mix well, Obtain polymer mixed solution;

[0034] S 2 , add 0.2g of green tea extract powder to the polymer mixed solution, mix evenly, then add 1ml of glycerin to foam for 30min, add 5ml of calcium chloride solution with a solution concentration of 1% after foaming to promote chitosan and carboxymethyl shell Glycans are cross-linked to obtain a cross-linked polymer solution;

[0035] S 3 , put the cross-linked polymer solution at -20~-80°C for 24 hours, then take it out and immediately freeze-dry it for 24 hours to obtain a hemostatic sponge, which is finally cut into shape and sterilized by UV, and then stored in a dry box at 37°C in spare.

[0036] The green te...

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Abstract

The invention discloses hemostatic sponge and a preparation process thereof, and belongs to the technical field of medical products. The preparation process comprises the following steps: S1, adding carboxymethyl chitosan into deionized water to obtain a carboxymethyl chitosan polymer solution, and adding chitosan into the carboxymethyl chitosan polymer solution to obtain a polymer mixed solution;S2, adding green tea extract powder into the polymer mixed solution, uniformly mixing, further adding glycerinum for foaming, and after foaming is completed, adding a calcium chloride solution to promote cross-linking of the chitosan and carboxymethyl chitosan to obtain a cross-linked polymer solution; S3, freezing and drying the cross-linked polymer solution to obtain the hemostatic sponge, andfinally shearing and modeling the hemostatic sponge. The hemostatic sponge disclosed by the invention has very large water absorption and expansion capacity, is capable of stopping bleeding rapidly and has a treatment effect of promoting wound healing.

Description

technical field [0001] The invention relates to a technology in the field of medical supplies, in particular to a hemostatic sponge and a preparation process thereof. Background technique [0002] In military and civilian trauma, hemorrhage is one of the main causes of death. After massive hemorrhage, in addition to high medical costs, blood transfusion may cause complications such as coagulation disorders, infection, and organ failure. Therefore, timely hemostatic treatment of bleeding trauma is extremely important to reduce blood loss, improve survival and achieve optimal recovery. Autopsy reports from the Iraq and Afghanistan wars indicated that effective hemostatic treatment could have prevented nearly 24% of war deaths. The hemostatic material can significantly reduce the amount of bleeding, and the wounded can save themselves, gaining more time for later treatment. [0003] In order to avoid wound infection, the material needs to have good antibacterial activity whil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00C08L5/08C08K5/00C08J9/14C08J3/24
CPCA61L24/0005A61L24/001A61L24/0015A61L24/0036A61L24/08A61L2300/30A61L2300/404A61L2400/04C08J3/246C08J9/0061C08J9/142C08J2305/08C08J2405/08C08K5/0058C08L5/08
Inventor 高雅薛鹏
Owner 元化科技(嘉兴)有限公司
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