Hemostatic sponge and preparation process thereof

Abstract

The invention discloses hemostatic sponge and a preparation process thereof, and belongs to the technical field of medical products. The preparation process comprises the following steps: S1, adding carboxymethyl chitosan into deionized water to obtain a carboxymethyl chitosan polymer solution, and adding chitosan into the carboxymethyl chitosan polymer solution to obtain a polymer mixed solution;S2, adding green tea extract powder into the polymer mixed solution, uniformly mixing, further adding glycerinum for foaming, and after foaming is completed, adding a calcium chloride solution to promote cross-linking of the chitosan and carboxymethyl chitosan to obtain a cross-linked polymer solution; S3, freezing and drying the cross-linked polymer solution to obtain the hemostatic sponge, andfinally shearing and modeling the hemostatic sponge. The hemostatic sponge disclosed by the invention has very large water absorption and expansion capacity, is capable of stopping bleeding rapidly and has a treatment effect of promoting wound healing.

Description

technical field [0001] The invention relates to a technology in the field of medical supplies, in particular to a hemostatic sponge and a preparation process thereof. Background technique [0002] In military and civilian trauma, hemorrhage is one of the main causes of death. After massive hemorrhage, in addition to high medical costs, blood transfusion may cause complications such as coagulation disorders, infection, and organ failure. Therefore, timely hemostatic treatment of bleeding trauma is extremely important to reduce blood loss, improve survival and achieve optimal recovery. Autopsy reports from the Iraq and Afghanistan wars indicated that effective hemostatic treatment could have prevented nearly 24% of war deaths. The hemostatic material can significantly reduce the amount of bleeding, and the wounded can save themselves, gaining more time for later treatment. [0003] In order to avoid wound infection, the material needs to have good antibacterial activity whil...

AI Technical Summary

Problems solved by technology

However, chitosan has no solubility in neutral aqueous solution, and its foaming performance is poor. It often needs to be dissolved in acidic solution, thereby limiting its antibacterial performance. Chitosan needs to be cross-linked with glutaraldehyde to obtain Hemostatic sponge, these processes are easy to affect the environment, and the residual aldehyde crosslinking agent is easy to produce toxicity

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