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Thyroid dysfunction model and establishment method thereof

A technology for thyroid function and establishment method, which is applied in the field of thyroid dysfunction model and establishment, can solve problems such as the increase of optimization iteration time, and achieve the effect of low-cost detection

Inactive Publication Date: 2019-02-15
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Abstract
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  • Application Information

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Problems solved by technology

Compared with the improvement of the accuracy of the target value, it is more obvious that it causes a serious increase in the optimization iteration time

Method used

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  • Thyroid dysfunction model and establishment method thereof
  • Thyroid dysfunction model and establishment method thereof
  • Thyroid dysfunction model and establishment method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (1) Serum sample collection and processing:

[0056] Fresh blood from 34 patients with thyroid dysfunction and 40 patients with normal thyroid function were collected. Without adding any anticoagulant, 3 ml of fresh blood was collected from each patient and placed in a clean environment at 37°C for condensation for one hour. Then use a high-speed centrifuge (4000 rpm) to centrifuge the blood at 4°C for 5 minutes to extract the serum to obtain a serum sample. Then put it into a centrifuge tube and store it in a refrigerator at 80°C for subsequent use.

[0057] (2) Serum Raman spectrum detection:

[0058] Use the Horiba confocal Raman spectrometer to detect serum samples, the excitation wavelength used is an argon ion laser with a wavelength of 532nm, and the focus is on detection at 400-1800cm -1 wavenumber range to obtain serum Raman spectra. The parameters are set as follows: the microscope is a 50x objective lens, the integration time is 5s, and the excitation wav...

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Abstract

The invention relates to a thyroid dysfunction model and an establishment method thereof. The method comprises steps that (1), fresh blood from patients with the thyroid dysfunction and persons with the normal thyroid function are collected; serum is extracted to obtain serum samples; (2), the serum samples are detected through a Horiba confocal Raman spectrograph to obtain the serum Raman spectra; (3), fitting of all the serum autofluorescence background is performed, a baseline is corrected, and the corrected spectral data is subjected to integral area normalization processing to obtain thespectral data after processing; and (4), after the processed spectral data is subjected to dimensionality reduction and feature extraction through the PCA method, a SVM classification model is established, and the thyroid dysfunction model is obtained. The method is advantaged in the thyroid dysfunction model is established, based on the model, fast low-cost detection of thyroid diseases can be achieved.

Description

technical field [0001] The invention specifically relates to a thyroid dysfunction model and its establishment method. Background technique [0002] The incidence of thyroid disease is increasing year by year worldwide, and the average mortality rate is about 12%-17%. Patients with thyroid diseases need to be checked frequently. For example, patients with hypothyroidism need to be followed up for life-long thyroid function, and hyperthyroidism is generally reviewed once a month. In addition, thyroid dysfunction has become a risk factor for many diseases, such as cardiovascular and cerebrovascular diseases, reproductive system diseases and diabetes. At present, the main methods of thyroid function detection are radioimmunoassay (RIA) and luminescent immunoassay. However, these two methods not only require large-scale biochemical detection equipment, but also require a long detection time (5-6h) and professional operation. With the increasing prevalence, only large hospital...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H30/20G16H50/50
CPCG16H30/20G16H50/50
Inventor 杜国利申红丽马兰包建玲李玉革吕小毅郑向向
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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