Carboxymethyl glycosaminoglycan derivative and preparation method and application thereof

A technology of polysaccharide derivatives and carboxymethylamino, which is applied in the field of carboxymethylaminopolysaccharide derivatives and their preparation, can solve the problems of restricting the application of chitosan, failing to meet market requirements, weak biological activity, etc., and meet the requirements of equipment and raw materials Easy to obtain, easy to promote, and low-cost effects

Active Publication Date: 2019-02-19
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the weak biological activity of chitosan itself, it cannot m

Method used

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  • Carboxymethyl glycosaminoglycan derivative and preparation method and application thereof
  • Carboxymethyl glycosaminoglycan derivative and preparation method and application thereof
  • Carboxymethyl glycosaminoglycan derivative and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0027] In this embodiment, the target compound carboxymethyl amino polysaccharide derivative is synthesized according to the above synthetic route, specifically:

[0028] 1) Preparation of carboxymethyl chitosan: Take 5g of chitosan and add it to 35mL of isopropanol, stir and swell for 2h, then dissolve 25g of sodium hydroxide in 25mL of water and pour it into the above-mentioned swollen solution to obtain alkali Chitosan-isopropanol system. After stirring evenly, place it at -18°C for 12 hours. Weigh 17.61g of chloroacetic acid, heat and dissolve it in 10mL of isopropanol, add it into the above-mentioned alkaline chitosan-isopropanol system in five batches under ice bath, and then react at 60°C for 5h, and then react backward Pour 100mL of water into the system to dissolve the solids in the reaction system, adjust the pH of the system to 8 with 10% hydrochloric acid, then pour the resulting solution into 800mL of absolute ethanol to precipitate, filter with suction, wash wit...

Embodiment 2

[0031] The difference from Example 1 is:

[0032] 1) Preparation of carboxymethyl chitosan: Weigh 5g of chitosan and add it to 40mL of isopropanol, stir and swell for 2h, then dissolve 30g of sodium hydroxide in 30mL of water and pour it into the above-mentioned swollen solution to obtain alkali Chitosan-isopropanol system. After stirring evenly, place it at -20°C for 10 hours. Weigh 14.67g of chloroacetic acid, heat and dissolve it in 10mL of isopropanol, add it into the above-mentioned alkaline chitosan-isopropanol system in five batches under ice bath, and then react at 50°C for 10h, and then react backward Pour 100mL of water into the system to dissolve the solids in the reaction system, adjust the pH of the system to 8 with 10% hydrochloric acid, pour the resulting solution into 800mL of absolute ethanol to precipitate, filter with suction, wash with absolute ethanol, and dry in vacuum at -50°C for 24h , to obtain carboxymethyl chitosan (see figure 2 ) 9.62g, spare. ...

Embodiment 3

[0035] The difference from Example 1 is:

[0036] 1) Preparation of carboxymethyl chitosan: Take 5g of chitosan and add it to 35mL of isopropanol, stir and swell for 2h, then dissolve 25g of sodium hydroxide in 25mL of water and pour it into the above-mentioned swollen solution to obtain alkali Chitosan-isopropanol system. After stirring evenly, place it at -20°C for 10 hours. Weigh 17.61g of chloroacetic acid, heat and dissolve it in 10mL of isopropanol, add it into the above-mentioned alkaline chitosan-isopropanol system in five batches under ice bath, and then react at 50°C for 10h, and then react backward Pour 100mL of water into the system to dissolve the solids in the reaction system, adjust the pH of the system to 8 with 10% hydrochloric acid, pour the resulting solution into 800mL of absolute ethanol to precipitate, filter with suction, wash with absolute ethanol, and dry in vacuum at -50°C for 24h , to obtain carboxymethyl chitosan (see figure 2 ) 10.51g, spare. ...

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Abstract

The invention relates to the field of foods, in particular to a carboxymethyl glycosaminoglycan derivative and a preparation method and application thereof. The structural formula of the carboxymethylglycosaminoglycan derivative is shown in the formula (1), wherein the average degree of polymerization n is within the range from 10 to 3000. The carboxymethyl glycosaminoglycan derivative is easy toprepare and easy to popularize, and the required device and raw materials are easy to obtain. Research shows that the carboxymethyl glycosaminoglycan derivative synthesized by using the method is good in water solubility, excellent in film forming property and refreshing property, capable of slowing loss of water in fruits and capable of being widely applied in the field of fruit refreshing. (Theformula is shown in the description.).

Description

technical field [0001] The invention relates to the field of food, in particular to a carboxymethyl amino polysaccharide derivative and a preparation method and application thereof. Background technique [0002] Chitin is mainly found in the shells of shrimps, crabs and insects, and is the second most abundant sugar resource after cellulose in nature. Chitosan is an amino polysaccharide obtained by deacetylation of chitin. Chitosan is a safe, non-toxic, biocompatible, and biodegradable polysaccharide, which has many unique physiological and pharmacological functional properties, and is widely used in various industries such as medicine, food, agriculture, daily chemicals, and environmental protection. in the field. However, due to the weak biological activity of chitosan itself, it cannot meet the market requirements, which greatly limits the application of chitosan. Chitosan contains active -OH, -NH 2 , Through the chemical modification of chitosan and the introduction ...

Claims

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Application Information

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IPC IPC(8): C08B37/08A23B7/16
CPCA23B7/16C08B37/003
Inventor 郭占勇秦荣基谭文强秦荣珍董方姜峰
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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