Novel embedded type eight-component medicinal powder with whitening and freckle removing functions and preparation method thereof

A whitening and freckle-removing, encapsulating technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve good whitening effects, stable properties, and overcoming irritation effects

Inactive Publication Date: 2019-02-22
佛山市奥姿美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to solve the problems existing in the use process of existing whitening and freckle-removing produc...

Method used

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  • Novel embedded type eight-component medicinal powder with whitening and freckle removing functions and preparation method thereof
  • Novel embedded type eight-component medicinal powder with whitening and freckle removing functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Preparation of Xinbabaisan Extract: Most of the tyrosinase inhibitors extracted from natural products contain polar groups such as carboxyl and hydroxyl groups. Ethanol with different volume fractions is selected as the extraction solvent, and the optimal composition ratio is selected. , fixed solid-liquid ratio and other extraction conditions, the evaluation indexes were tyrosinase inhibition rate and DPPH free radical scavenging rate. Weigh each 10g of silkworm, Tribulus terrestris, Bletilla striata, Poria cocos, Cortex mulberry, Poria radix, Paeoniae Alba and pearl powder in the optimal proportion, 8 parts in total, use 35% ethanol, 50% ethanol, 65% ethanol in sequence , 80% ethanol, 95% ethanol, and absolute ethanol are used as extraction solvents for extraction, and the amount of extraction solvent used each time is 100 parts by volume, and each extraction is performed for 4 hours; Concentrate under pressure to prepare 10mL of liquid medicine (namely Xinbabaisa...

Embodiment 2

[0046] Contrastive experiment of encapsulated Xinbabaisan extract and unencapsulated extract.

[0047] 1. Comparative experiment on inhibition of tyrosinase between encapsulated Xinbabaisan extract and unencapsulated extract: with a mass concentration of 8 μg / mL encapsulated Xinbabaisan extract and unencapsulated Xinbabaisan extract , with L-tyrosine solution (1.5mmol / L) as substrate, with the concentration of 1.42mmol / L vitamin C as reference substance, measure the effect of wrapped type Xinbabaisan extract and unwrapped Xinbabaisan extract on tyrosine Inhibition rate of amino acid monophenolase activity.

[0048] With the same mass concentration of Xinbabaisan extract and wrapped type Xinbabaisan extract, with L-dopa solution (1.5mmol / L) as substrate, with the concentration of vitamin C as 1.42mmol / L as reference substance, determine Inhibition rate of packaged Xinbabaisan extract and uncoated Xinbabaisan extract on tyrosinase diphenolase. The results are shown in Table 2:...

Embodiment 3

[0057] Stability Evaluation of Packaged Xinbabai Powder

[0058] 1. Evaluation of thermal stability

[0059] The wrapped Xinbabaisan extract prepared in Example 1 and the unwrapped extract were respectively placed in transparent glass bottles and placed in a constant temperature test box at 48°C, and the appearance of the product was observed every 3 days.

[0060] The experimental results show that the color of the unwrapped extract starts to change from white to slightly yellow in 8 days, and gradually deepens in color as time goes by; the wrapped type Xinbabaisan extract is continuously observed for 25 days, and the color of the product is uniform. Still remain white, there is no phenomenon of color change. This shows that after liposome encapsulation, the heat-resistant stability of the whitening and freckle-removing ingredients is greatly improved.

[0061] 2. Light stability evaluation

[0062] The wrapped Xinbabaisan extract prepared in Example 1 and the unwrapped ex...

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Abstract

The invention belongs to the technical field of cosmetics, in particular to novel embedded type eight-component medicinal powder with the whitening and freckle removing functions and a preparation method thereof. The novel embedded type eight-component medicinal powder is mainly prepared from the following components in parts by mass: 10 parts of white muscardine silkworms, 10 parts of tribulus terrestris, 10 parts of bletilla striata, 10 parts of white poria, 10 parts of white mulberry root-bark, 10 parts of radix ampelopsis, 10 parts of white peony roots and 10 parts of pearl powder. According to the novel embedded type eight-component medicinal powder and the preparation method thereof, the activity of tyrosinase is regulated and controlled in a synergistic manner according to differentactivation cell signaling pathways of the components, and in addition, the medicinal powder can be fully embedded in liposome and play a role in activity and is an organic combination of a traditional active substance and a modern preparation technology; and the defects that traditional eight-component medicinal powder has a certain stimulation effect and can cause anaphylactic reaction can be overcome, and a good whitening effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a wrapped-type xinbabai powder capable of whitening and removing freckles and a preparation method thereof. Background technique [0002] The color of normal human skin mainly depends on the content and distribution of melanin. Melanin is synthesized in melanocytes, and its production is mainly regulated by tyrosinase activity. When the activity of tyrosinase increases, the synthesis of melanin will increase, otherwise, the production of melanin will decrease significantly. The disorder or increase of tyrosinase can cause pigment diseases such as chloasma, freckles, brown spots, dark spots, age spots and even melanoma. Tyrosine in melanocytes is gradually oxidized into melanin under the action of enzymes such as tyrosinase. In recent years, skin whitening agents that inhibit or block tyrosinase activity have been developed successively at home and abroad, such as...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/9789A61K8/9794A61K8/9728A61K8/14A61Q19/02
CPCA61K8/14A61K8/987A61K2800/56A61K2800/782A61Q19/02A61K8/9728A61K8/9789A61K8/9794
Inventor 张彩华林华庆陈宏远芮雯
Owner 佛山市奥姿美生物科技有限公司
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