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Photoresponsive degradable hollow mesoporous organic silicon nano composite particles as well as preparation method and application thereof

A nano-composite particle, hollow mesoporous technology, applied in organic chemistry, organic active ingredients, chemical instruments and methods, etc., can solve the problems of few types of degradable silicone nanoparticles, limited application, etc., to avoid toxic side effects, achieve Safe metabolism and the effect of increasing the load

Active Publication Date: 2019-02-22
XUZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the types of stimuli-responsive degradable silicone nanoparticles are relatively small, which limits their application as anti-tumor drug carriers to a certain extent.

Method used

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  • Photoresponsive degradable hollow mesoporous organic silicon nano composite particles as well as preparation method and application thereof
  • Photoresponsive degradable hollow mesoporous organic silicon nano composite particles as well as preparation method and application thereof
  • Photoresponsive degradable hollow mesoporous organic silicon nano composite particles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Preparation of bridged alkoxysilane precursor containing anthraquinone group

[0035] Take 0.05g of 9,10-bis(3-hydroxypropoxy)anthraquinone, 0.038g of isocyanate propyltriethoxysilane, 0.0155g of triethylamine and add 20ml of dichloromethane to dissolve, and stir at reflux for 12h at 60°C . The product is purified by a chromatographic column to obtain a bridged alkoxysilane precursor containing anthraquinone groups. figure 1 It is the NMR spectrum of the bridged alkoxysilane precursor containing anthraquinone groups. It can be clearly seen from the figure that the molecule has been successfully synthesized.

Embodiment 2

[0036] Embodiment 2 Preparation of bridged alkoxysilane precursor containing anthraquinone group

[0037] The preparation method is basically the same as in Example 1, except that the mass ratio of the triethylamine, silane coupling agent, and 9,10-bis(3-hydroxypropoxy)anthraquinone is 1:2:3, The organic solvent is tetrahydrofuran, and stirred under reflux at 50° C. for 24 h.

Embodiment 3

[0038] Example 3 Preparation of bridged alkoxysilane precursor containing anthraquinone group

[0039] The preparation method is basically the same as in Example 1, except that the mass ratio of the triethylamine, silane coupling agent, and 9,10-bis(3-hydroxypropoxy)anthraquinone is 2:3:3, The organic solvent is tetrahydrofuran, and stirred under reflux at 80° C. for 8 h.

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Abstract

The invention discloses photoresponsive degradable hollow mesoporous organic silicon nano composite particles as well as a preparation method and application thereof. The preparation method comprisesthe following steps: firstly, preparing a bridged alkoxy silane precursor containing anthraquinone groups; and then introducing the precursor into a shell framework of hollow mesoporous organic silicon nano-particles to obtain hollow mesoporous organic silicon nano-particles, and modifying graphene oxide quantum dots on the surface to obtain the photoresponsive degradable hollow mesoporous organicsilicon nano composite particles. The hollow mesoporous structure ensures that the nano-particles have high drug load when being used as anti-tumor drug carriers; and under the condition of illumination, the nano composite particles can be degraded, so that not only can the loaded drugs be efficiently released, but also the self-degradation ensures the safe metabolism of the carriers and avoids enrichment of toxicity.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and specifically relates to photoresponsive degradable hollow mesoporous organic silicon nanocomposite particles, a preparation method and application thereof, and the application relates to being used as a drug carrier. Background technique [0002] At present, chemotherapy is one of the main means of clinical treatment of cancer, but anti-tumor drugs have huge side effects, not only have a killing effect on tumor cells, but also may cause irreversible damage to normal tissues of the human body. One of the effective ways to solve this problem is to prepare nano anti-tumor drug carriers. Nano-drug carriers can passively target and enrich tumor sites through the enhanced penetration effect of tumor cells, thereby increasing the utilization efficiency of anti-tumor drugs and reducing their toxic and side effects. [0003] Inorganic nano drug carrier (SiO 2 , Fe 3 o 4 , CaCO 3 e...

Claims

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Application Information

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IPC IPC(8): C07F7/18A61K9/51A61K47/24A61K31/704A61P35/00
CPCA61K9/5123A61K31/704A61P35/00C07F7/1892
Inventor 杨舜杨清杨文越张志鹏
Owner XUZHOU NORMAL UNIVERSITY
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