Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Photoresponsive degradable hollow mesoporous silicone nanocomposite particles and its preparation method and application

A nano-composite particle, hollow mesoporous technology, applied in the fields of organic chemistry, organic active ingredients, chemical instruments and methods, etc., can solve the problems of limited application and few types of degradable silicone nanoparticles.

Active Publication Date: 2020-10-30
XUZHOU NORMAL UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the types of stimuli-responsive degradable silicone nanoparticles are relatively small, which limits their application as anti-tumor drug carriers to a certain extent.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Photoresponsive degradable hollow mesoporous silicone nanocomposite particles and its preparation method and application
  • Photoresponsive degradable hollow mesoporous silicone nanocomposite particles and its preparation method and application
  • Photoresponsive degradable hollow mesoporous silicone nanocomposite particles and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation of bridged alkoxysilane precursor containing anthraquinone groups

[0035] Take 0.05g of 9,10-bis(3-hydroxypropoxy)anthraquinone, 0.038g of isocyanate propyltriethoxysilane, 0.0155g of triethylamine, add 20ml of dichloromethane to dissolve, reflux and stir for 12h at 60℃ . The product is purified by a chromatographic column to obtain a bridged alkoxysilane precursor containing an anthraquinone group. figure 1 It is the NMR spectrum of the bridged alkoxysilane precursor containing anthraquinone groups. It can be clearly seen from the figure that the molecule has been successfully synthesized.

Embodiment 2

[0036] Example 2 Preparation of bridged alkoxysilane precursor containing anthraquinone groups

[0037] The preparation method is basically the same as in Example 1, except that the mass ratio of the triethylamine, the silane coupling agent, and 9,10-bis(3-hydroxypropoxy)anthraquinone is 1:2:3, The organic solvent is tetrahydrofuran, which is refluxed and stirred at 50°C for 24 hours.

Embodiment 3

[0038] Example 3 Preparation of bridged alkoxysilane precursor containing anthraquinone groups

[0039] The preparation method is basically the same as that of Example 1, except that the mass ratio of the triethylamine, silane coupling agent, and 9,10-bis(3-hydroxypropoxy)anthraquinone is 2:3:3, The organic solvent is tetrahydrofuran, which is refluxed and stirred at 80°C for 8 hours.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses photoresponsive degradable hollow mesoporous organic silicon nano composite particles as well as a preparation method and application thereof. The preparation method comprisesthe following steps: firstly, preparing a bridged alkoxy silane precursor containing anthraquinone groups; and then introducing the precursor into a shell framework of hollow mesoporous organic silicon nano-particles to obtain hollow mesoporous organic silicon nano-particles, and modifying graphene oxide quantum dots on the surface to obtain the photoresponsive degradable hollow mesoporous organicsilicon nano composite particles. The hollow mesoporous structure ensures that the nano-particles have high drug load when being used as anti-tumor drug carriers; and under the condition of illumination, the nano composite particles can be degraded, so that not only can the loaded drugs be efficiently released, but also the self-degradation ensures the safe metabolism of the carriers and avoids enrichment of toxicity.

Description

Technical field [0001] The invention belongs to the technical field of nanocomposite materials, and specifically relates to light-responsive degradable hollow mesoporous organic silicon nanocomposite particles, and preparation methods and applications thereof. The application relates to being used as a drug carrier. Background technique [0002] At present, one of the main methods for treating cancer clinically is chemotherapy, but anti-tumor drugs have huge side effects. They not only kill tumor cells, but may also cause irreversible damage to normal human tissues. One of the effective ways to solve this problem is to prepare nanometer anti-tumor drug carriers. The nano-medicine carrier can passively target and enrich the tumor site through the enhanced penetration effect of tumor cells, thereby increasing the utilization efficiency of anti-tumor drugs and reducing their toxic and side effects. [0003] Inorganic Nano Drug Carrier (SiO 2 , Fe 3 O 4 , CaCO 3 The research and devel...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07F7/18A61K9/51A61K47/24A61K31/704A61P35/00
CPCA61K9/5123A61K31/704A61P35/00C07F7/1892
Inventor 杨舜杨清杨文越张志鹏
Owner XUZHOU NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com