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A kind of preparation method of block copolymer with light response, reduction response and pH response

A block copolymer and light-responsive technology, which is applied in the field of block copolymer preparation, can solve the problems such as the decrease of the hydrophilic ability of acrylic acid, and achieve good entrapment and controlled release performance, good stability, and good multiple responsiveness. Effect

Active Publication Date: 2020-02-11
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under acidic conditions, -COOH will be inhibited, resulting in a decrease in the hydrophilicity of acrylic acid.

Method used

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  • A kind of preparation method of block copolymer with light response, reduction response and pH response
  • A kind of preparation method of block copolymer with light response, reduction response and pH response
  • A kind of preparation method of block copolymer with light response, reduction response and pH response

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1) Synthesis of PtBAn macromolecular chain transfer agent

[0038] Tert-butyl acrylate (2.56g), cumyl dithiobenzoate CDB (0.054g) and azobisisobutyronitrile (0.0064g) were dissolved in 4mL of tetrahydrofuran, and after several freeze-thaw degassing operations, After ensuring that the solvent no longer contains air, argon gas was passed into it, and after 24 hours of reaction at 65°C, it was quenched with liquid nitrogen to stop the reaction, and the ratio of methanol:water=2:1 was used as the first precipitant, and the precipitation was repeated for 3 time, then dry to obtain the product PtBA macromolecular chain transfer agent (GPC curve such as figure 2 shown);

[0039] 2) PAA n -b-P(PEGMA x -co-AzoMA y ) m Synthesis of Block Copolymers

[0040]Take the PtBA macromolecular chain transfer agent (0.8g), AIBN (0.032g), azobenzene monomer (1.68g) and PEGMA (0.118g) synthesized in step 1) and dissolve them in 6mL of tetrahydrofuran. Gas operation, after ensuring th...

Embodiment 2

[0042] 1) Synthesis of PtBAn macromolecular chain transfer agent

[0043] Tert-butyl acrylate (2.56g), cumyl dithiobenzoate CDB (0.054g) and azobisisobutyronitrile (0.0064g) were dissolved in 4mL of tetrahydrofuran, and after continuous freeze-thaw degassing operations, After ensuring that the solvent no longer contains air, argon gas was introduced, and after 24 hours of reaction at 65 ° C, it was quenched with liquid nitrogen to stop the reaction. The ratio of methanol: water = 3: 1 was used as the first precipitant, and the precipitation was repeated for 3 time, then dry to obtain the product PtBA macromolecular chain transfer agent;

[0044] 2) PAA n -b-P(PEGMA x -co-AzoMA y ) m

[0045] Get step 1) synthetic PtBA macromolecular chain transfer agent (0.8g), AIBN (0.00165g), azobenzene monomer (0.7077g), PEGMA (0.118g) is dissolved in 6mL THF, through continuous freezing and thawing Gas operation, after ensuring that the solvent no longer contains air, argon gas is in...

Embodiment 3

[0048] 1) Synthesis of PtBAn macromolecular chain transfer agent

[0049] Tert-butyl acrylate (3.84g), cumyl dithiobenzoate CDB (0.054g) and azobisisobutyronitrile (0.0066g) were dissolved in 4mL of tetrahydrofuran, and after continuous freeze-thaw degassing operations, After ensuring that the solvent no longer contains air, argon gas was introduced, and after 24 hours of reaction at 65 ° C, it was quenched with liquid nitrogen to stop the reaction. The ratio of methanol: water = 3: 1 was used as the first precipitant, and the precipitation was repeated for 3 time, then dry to obtain the product PtBA macromolecular chain transfer agent;

[0050] 2) PAAn-b-P(PEGMAx-co-AzoMAy)m

[0051] Get step 1) synthetic PtBA macromolecular chain transfer agent (0.775g), AIBN (0.00165g), azobenzene monomer (0.5055g), PEGMA (0.118g) is dissolved in 6mL tetrahydrofuran, through continuous freeze-thaw Gas operation, after ensuring that the solvent no longer contains air, argon gas is introduc...

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Abstract

The invention discloses a preparation method of a segmented copolymer having photoresponse, reduction response and pH response. The preparation method disclosed by the invention comprises the following steps: by taking polybutyl acrylate as a first block, and taking an azobenzene monomer and polyethylene glycol methacrylate as a second block, performing RAFT polymerization, thereby obtaining the segmented copolymer which has photoresponse, reduction response and pH response and is capable of forming micelles in water by virtue of self-assembly. According to the assembled micelles, by changingthe external environment, such as UV irradiation and addition of the reduction agent or regulating the pH value of the micelle solution, the morphology of the micelles can be changed.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a preparation method of a block copolymer with light response, reduction response and pH response. Background technique [0002] Environment-responsive copolymers, also known as stimuli-responsive copolymers, are polymers that can make corresponding changes after the external physical environment changes. Responsive amphiphilic block copolymers have become one of the research hotspots due to their good water solubility and stimuli responsiveness. When external stimuli (such as: magnetic field, pH, light, ionic strength) change, the block copolymer itself will also change with the change of external factors. [0003] Azobenzene compounds refer to compounds formed by replacing the hydrogen atoms in HN=NH with benzene or benzene derivatives. Azobenzene compounds exist in the form of cis-trans isomerism. Since the thermal stability of trans-azobenzene is bette...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00
CPCC08F293/005C08F2438/01
Inventor 许一婷曹杰戴李宗沈童李萌王宏超何锴慰陈国荣
Owner XIAMEN UNIV
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