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Preparation method for regulating spherical nano silicon particles and spherical mesoporous nano silicon particles

A nano-silicon and spherical technology, which is applied in the field of preparation of spherical nano-silicon particles and spherical mesoporous nano-silicon particles, to achieve uniform particle size distribution, uniform pore structure, and low production costs

Inactive Publication Date: 2019-03-01
中国医科大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is still challenging to develop a preparation method that can adjust different sizes, different pore sizes, and good dispersion and roundness of nano-silicon particles.

Method used

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  • Preparation method for regulating spherical nano silicon particles and spherical mesoporous nano silicon particles
  • Preparation method for regulating spherical nano silicon particles and spherical mesoporous nano silicon particles
  • Preparation method for regulating spherical nano silicon particles and spherical mesoporous nano silicon particles

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Experimental program
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Effect test

Embodiment 1

[0036] Add 1.5 g of cetyltrimethylammonium bromide and 0.17 g of sodium acetate (1:0.5 molar ratio) into 100 ml of deionized water, stir and dissolve at 95 °C for 30 minutes, add 2 ml of ethyl orthosilicate Stir the reaction for 2 hours, centrifuge at 12000 rpm for 20 minutes, discard the supernatant; disperse and centrifuge with 20 ml of water or ethanol, repeat washing 2-3 times, and dry to obtain spherical mesoporous silicon with a particle size of 76±5 nm Nano silicon particles ( figure 1 ).

Embodiment 2

[0038] Add 1.5 grams of cetyltrimethylammonium bromide and 0.17 grams of sodium acetate (molar ratio: 1:0.5) into 100 milliliters of deionized water, stir and dissolve at 95 ° C for 30 minutes, add 4 milliliters of ethyl orthosilicate Stir the reaction for 2 hours, centrifuge at 12000 rpm for 20 minutes, discard the supernatant; disperse and centrifuge with 20 ml of water or ethanol, wash repeatedly 2-3 times, and dry to obtain a spherical mesoporous nanometer with a particle size of 97±4 nanometers. Silicon particles ( figure 2 ).

Embodiment 3

[0040] Add 1.5 g of cetyltrimethylammonium bromide and 0.23 g of sodium butyrate (molar ratio 1:0.5) into 100 ml of deionized water, stir and dissolve at 95°C for 30 minutes, add 2 ml of ethyl orthosilicate Stir the reaction for 2 hours, centrifuge at 12000 rpm for 20 minutes, discard the supernatant; disperse and centrifuge with 20 ml of water or ethanol, and wash repeatedly 2-3 times to obtain spherical mesoporous nano-silicon particles with a particle size of 89±5 nm ( image 3 ).

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Abstract

The invention belongs to the field of a novel method for preparing a nano material for the pharmaceutical and chemical industry, and particularly relates to a preparation method for regulating spherical nano silicon particles and spherical mesoporous nano silicon particles. The preparation method first adopts fatty acid salt and cationic surface active agent to form a mixed surface active agent which is used as a template molecule, the spherical mesoporous nano silicon particles (less than 100nm) and spherical nano silicon particles (about 200nm or greater) can be regulated and prepared by regulating the consumption of a silicon precursor agent, and a chemical nature is a polymer of silicon dioxide. The preparation method of the invention is mild, environment-friendly, easy in amplified production and easy in mass production; and an obtained product is stable in structure, good in dispersion performance and capable of being used as a carrier of difficult-to-dissolve and biological macromolecular drugs.

Description

technical field [0001] The invention belongs to the field of new methods for preparing nanomaterials used in medicine and chemical industry, and in particular relates to a preparation method for adjusting and controlling spherical nano-silicon particles and spherical mesoporous nano-silicon particles. Background technique [0002] Mesoporous silicon nanomaterials (particle size less than 500 nm) have many technical advantages, such as high specific surface area and pore volume, good colloidal stability, excellent biocompatibility, etc. In addition, the particle size, mesopore diameter and morphology can be adjusted, and the surface and interior of the particles can be chemically modified to make them functional. Engineering, drug carrier, etc.) have extensive and important application prospects. [0003] The good adsorption and loading capacity of mesoporous nano-silicon materials make them candidates for catalysts and drug molecule carriers, and have aroused widespread int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/021B82Y30/00B82Y40/00A61K47/04A61K47/69
CPCA61K47/02A61K47/6949B82Y30/00B82Y40/00C01B33/021
Inventor 荀哲关一夫
Owner 中国医科大学
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