Preparation method of ferulic acid molecularly imprinted blend membrane material

A technology of molecular imprinting and ferulic acid, which is applied in chemical instruments and methods, and other chemical processes, can solve the problems of easy agglomeration, the influence of organic film strength and toughness, small particle size of nanoparticles, etc., and achieves simple and easy preparation Effect

Inactive Publication Date: 2019-03-01
LONGYAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After chemical modification, although the performance of the membrane is improved, the strength and toughness of the organic membrane are greatly affected and significantly decreased.
In the blending modification method, some nano-inorganic materials with excellent performance are usually used as blending materials to improve the hydrophilicity of the membrane. However, due to the small particle size and high specific surface activity of the nanoparticles, agglomeration is easy to occur, which leads to The performance of blended membranes decreased

Method used

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  • Preparation method of ferulic acid molecularly imprinted blend membrane material
  • Preparation method of ferulic acid molecularly imprinted blend membrane material
  • Preparation method of ferulic acid molecularly imprinted blend membrane material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This embodiment includes the following steps:

[0031] (1) Dissolve 0.0486g of ferulic acid and 0.0355g of acrylamide in acetonitrile and stir. After fully shaking, put it in the refrigerator and let it stand for 9-12h.

[0032] (2) Take the solution in step (1) out of the refrigerator, add 36.6mg of azobisisobutyronitrile and 1.24g of ethylene glycol dimethacrylate, then pass nitrogen gas for several minutes, and keep the temperature in a water bath at 60°C After heating for 24 hours, a large amount of white precipitates, namely ferulic acid molecularly imprinted microspheres, were obtained.

[0033] (3) The polymer microspheres in the step (2) are suction-filtered, and washed repeatedly with a mixed solution of methanol and acetic acid until no ferulic acid is detected.

[0034] (4) Weigh 4.95g of polysulfone and 0.05g of ferulic acid molecularly imprinted polymer microspheres, add 20ml of N,N-dimethylformamide, stir and heat at 65°C until the polysulfone (PSF) is co...

Embodiment 2

[0037] This embodiment includes the following steps:

[0038] (1) Dissolve 0.0484g of ferulic acid and 0.0533g of acrylamide in acetonitrile and stir. After fully shaking, put it in the refrigerator and let it stand for 9-12h.

[0039] (2) Take the solution in (1) out of the refrigerator, add 36.6mg of azobisisobutyronitrile and 1.24g of ethylene glycol dimethacrylate, then pass nitrogen gas for several minutes, and heat in a water bath at a constant temperature of 60°C for 24h , to obtain a large amount of white precipitate, that is, ferulic acid molecularly imprinted microspheres.

[0040](3) The polymer microspheres in (2) are suction-filtered, and washed repeatedly with a mixed solution of methanol and acetic acid until no ferulic acid is detected.

[0041] (4) Weigh 4.85g of polysulfone and 0.15g of ferulic acid molecularly imprinted polymer microspheres, add 25ml of N,N-dimethylformamide, stir and heat at 65°C until the polysulfone (PSF) is completely dissolved, Put th...

Embodiment 3

[0044] This embodiment includes the following steps:

[0045] (1) Dissolve 0.0486g of ferulic acid and 0.0711g of acrylamide in acetonitrile and stir. After fully shaking, put it in the refrigerator and let it stand for 9-12h.

[0046] (2) Take the solution in (1) out of the refrigerator, add 36.6mg of azobisisobutyronitrile and 1.24g of ethylene glycol dimethacrylate, then pass nitrogen gas for several minutes, and heat in a water bath at a constant temperature of 60°C for 24h , to obtain a large amount of white precipitate, that is, ferulic acid molecularly imprinted microspheres.

[0047] (3) The polymer microspheres in (2) are suction-filtered, and washed repeatedly with a mixed solution of methanol and acetic acid until no ferulic acid is detected.

[0048] (4) Weigh 4.75g of polysulfone and 0.25g of ferulic acid molecularly imprinted polymer microspheres, add 25ml of N,N-dimethylformamide, stir and heat at 65°C until the polysulfone (PSF) is completely dissolved, Put t...

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Abstract

The invention discloses a preparation method of a ferulic acid molecularly imprinted blend membrane material. The preparation method comprises the following operation steps: (1) dissolving a mixture of ferulic acid and acrylamide into acetonitrile, fully stirring, and putting in a refrigerator for standing; (2) adding azodiisobutyronitrile and the ferulic acid after taking out a solution, adding glycol dimethacrylate, introducing nitrogen, and heating in a water bath pot at a constant temperature of 50 to 60 DEG C, thus obtaining ferulic acid molecularly imprinted microspheres; (3) carrying out suction filtration on the polymer microspheres, and repeatedly washing by using a mixed solution of methanol and acetic acid until no ferulic acid is detected; (4) preparing a mixture of polysulfoneand the ferulic acid molecularly imprinted polymer microspheres, adding N,N-dimethyl formamide, stirring and heating at the constant temperature of 50 to 80 DEG C until the polysulfone is completelydissolving, putting and heating a completely dissolved casting solution in a vacuum drying machine at the constant temperature of 50 to 80 DEG C, and taking out and naturally air-drying a concentratedsolution with poorer fluidity, thus obtaining a ferulic acid molecularly imprinted blend membrane. The ferulic acid molecularly imprinted blend membrane prepared by the invention is high in specificsurface activity and good in comprehensive performance.

Description

technical field [0001] The invention relates to a method for preparing a film material for detecting the content of ferulic acid, in particular to a method for preparing a ferulic acid molecularly imprinted blended film material by a phase inversion method of imprinted molecules. Background technique [0002] Ferulic acid is a functional phenolic acid widely present in plants, and it is also the main active ingredient of the traditional Chinese medicine Chuanqiong. One of the active ingredients of traditional Chinese medicine has been used as one of the quality indicators of Chinese patent medicines; in food raw materials, the content of ferulic acid in coffee, chaff, pandan beans, wheat bran and rice bran is also high. Ferulic acid has strong anti-oxidation and anti-inflammation activities, and inhibits platelet aggregation and thrombus. Its chemical structure is 4-hydroxy 3-methoxycinnamic acid, which has strong anti-oxidation activity and can remove A variety of free rad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/56C08J5/18C08J9/28B01J20/26B01J20/30
CPCB01J20/268C08F222/10C08F222/102C08J5/18C08J9/28C08J2201/0502C08J2335/02C08F220/56
Inventor 董雁苏团
Owner LONGYAN UNIV
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