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PH/H2O2 double sensitivity intelligent hydrogel and preparation method and application thereof

A dual-sensitivity, hydrogel technology, applied in the field of smart hydrogels, can solve the problems of inability to achieve instantaneous response and difficulty in the circulation of the internal center, so as to increase the drug release rate, increase the storage modulus, and reduce the price of raw materials. cheap effect

Active Publication Date: 2019-03-01
SHANGHAI UNIV OF ENG SCI
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Problems solved by technology

The development of the pores of the hydrogel from porous → macropores → superpores can increase its response rate, and the response to drugs, especially macromolecular drugs such as proteins and polypeptide drugs, will be accelerated, but no matter how large the pores are, they will not change from the surface wall to the interior. The circulation of the center is still relatively difficult, and it is far from being able to achieve instantaneous response

Method used

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  • PH/H2O2 double sensitivity intelligent hydrogel and preparation method and application thereof
  • PH/H2O2 double sensitivity intelligent hydrogel and preparation method and application thereof
  • PH/H2O2 double sensitivity intelligent hydrogel and preparation method and application thereof

Examples

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Embodiment 1

[0046] (1) Preparation of guanosine quadruple / hemin complex (G4 / Hemin) solution:

[0047] a. Under the condition of 50°C water bath, fully dissolve 300-305mg boric acid (melting point 160°C) and 280-285mg potassium hydroxide (melting point 361°C) in 50mL deionized water respectively to form boric acid aqueous solution and potassium hydroxide aqueous solution;

[0048] b. Add 140-142mg of guanosine (melting point 250°C) into 2.5mL of boric acid aqueous solution, shake well and evenly, then place it in an ultrasonic cleaning machine, and ultrasonically disperse to obtain a guanosine emulsion;

[0049] c. Add 2.5mL aqueous potassium hydroxide solution to the guanosine emulsion in a water bath at 90°C, stir well until the solution is transparent, then add 0.3-0.32mg hemin (melting point 300°C) to obtain a G4 / Hemin complex solution .

[0050] (2) Preparation of graphene oxide aqueous solution: under ultrasonic conditions, 78 ~ 80mg graphene oxide (specific surface area 300 ~ 450m ...

Embodiment 2

[0065] (1) Preparation of guanosine quadruplet (G4) / hemin (Hemin) complex solution: same as step (1) of Example 1.

[0066] (2) Preparation of graphene oxide aqueous solution: same as step (2) of Example 1.

[0067] (3) Preparation of polyvinyl alcohol aqueous solution: same as step (3) of Example 1.

[0068] (4) Preparation of hydrogel precursor solution: same as step (4) of Example 1.

[0069] (5) Preparation of pH / H 2 o 2 Dual-sensitivity smart hydrogel: same as step (5) of Example 1, except that the volume ratio of the G4 / Hemin complex solution and the hydrogel precursor solution is 1:18.

[0070] The pH / H prepared in this embodiment 2 o 2 Inverted state of centrifuge tube of dual sensitive smart hydrogel, microscopic scanning electron microscope image, structural principle, H 2 o 2 Response result and the cycle independent phase transition result that changes with pH, ​​all with the pH / H that embodiment 1 prepares 2 o 2 The dual-sensitivity smart hydrogel is simi...

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Abstract

The invention belongs to the field of intelligent hydrogels, and particularly relates to a pH / H2O2 double sensitivity intelligent hydrogel and a preparation method and application thereof. According to the structure of the intelligent hydrogel, polyvinyl alcohol crosslinked graphene oxide forms a three-dimensional crosslinked network structure, tetra-guanosine / hemin compounds are stacked in the three-dimensional crosslinked network structure to form a three-dimensional crosslinked network system, and the three-dimensional crosslinked network system is filled with water. The preparation methodcomprises the following steps that polyvinyl alcohol and graphene oxide are self-assembled to form a hydrogel precursor; and the hydrogel precursor and the tetra-guanosine / hemin compound are self-assembled to form hydrogel. The hydrogel has double instantaneous sensitive response characteristics to pH and H2O2, can automatically circulate and continuously respond without regeneration, can be usedfor preparing drug carriers, sensors and molecular switches, and has wide application prospect.

Description

technical field [0001] The invention belongs to the field of intelligent hydrogel, in particular to a pH / H 2 o 2 A dual-sensitivity smart hydrogel and its preparation method and application, the smart hydrogel can quickly realize the continuous transformation of solution→gel→solution→gel. Background technique [0002] Polymer hydrogel is a gel with water as the dispersion medium. A part of hydrophobic groups are introduced into water-soluble polymers with a cross-linked structure to form a cross-linked polymer that swells with water. It is a polymer network system with properties Soft, holds its shape, and absorbs a lot of water. More than 90% of the polymer hydrogel is water, and the highly chemically cross-linked polymer network system has good hydrophilicity but is insoluble in water. Most biological hydrogels are cross-linked by hydrogen bonds or van der Waals forces to form a three-dimensional network structure, which can swell in water and retain a large amount of w...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08K3/04C08K5/55
CPCC08J3/075C08J2329/04C08K5/55C08K3/042
Inventor 张佳星鲁娜张敏张锐曾彩霞史雪荣
Owner SHANGHAI UNIV OF ENG SCI
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