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PEEK microballoon with special topological shape on surface, and preparation method and application thereof

A technology of microspheres and morphology, applied in pharmaceutical formulations, medical science, tissue regeneration, etc., can solve the problems of difficulty in obtaining PEEK microspheres, high technical requirements, and difficulty, and achieves accelerated bone healing process, low technical requirements, The effect of good mechanical properties

Active Publication Date: 2019-03-08
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the preparation methods in the prior art are all based on molecular design, introduction of functional groups, polymer synthesis, etc., with high technical requirements and great difficulty; more importantly, the above preparation methods are difficult to obtain materials that can meet the requirements of bone repair materials. PEEK microspheres required

Method used

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  • PEEK microballoon with special topological shape on surface, and preparation method and application thereof
  • PEEK microballoon with special topological shape on surface, and preparation method and application thereof
  • PEEK microballoon with special topological shape on surface, and preparation method and application thereof

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preparation example Construction

[0043] The present invention also provides a method for preparing the PEEK microspheres described in the above technical scheme, comprising the following steps:

[0044] a) dissolving polyether ether ketone in concentrated sulfuric acid, and obtaining a mixed liquid after standing;

[0045] b) the mixed solution obtained in step a) is prepared by air flow method to obtain PEEK microspheres with smooth surface;

[0046] c) performing a hydrothermal reaction with the smooth surfaced PEEK microspheres obtained in step b) and water in a reactor to obtain PEEK microspheres with special topological morphology on the surface;

[0047] The temperature of the hydrothermal reaction is 170°C-190°C, and the time is 7h-9h.

[0048] In the present invention, polyether ether ketone is firstly dissolved in concentrated sulfuric acid, and a mixed liquid is obtained after standing still. In the present invention, there is no special limitation on the source of the polyetheretherketone, and comm...

Embodiment 1

[0072] (1) Weigh 1.8g of PEEK powder, add it to 30mL of concentrated sulfuric acid, place it in a water bath at 25°C, stir it mechanically for 1h, and let it stand for 0.5h after the PEEK powder is completely dissolved to obtain a mixed liquid.

[0073] (2) Add the mixed liquid obtained in step (1) into a 50mL syringe with a Teflon needle diameter of 27G; equip with 1000mL of 30% ethanol sedimentation liquid, ice bath, the height of the needle head from the liquid surface of the above sedimentation liquid is 14cm, and prepare by airflow method For PEEK microspheres with smooth surface, the air flow rate is 7L / min~8L / min; after the PEEK microspheres with smooth surface are obtained, soak in water for 24 hours, change the water every 8 hours, and then filter with a sieve to obtain a diameter of 500μm~ 600μm smooth surface PEEK microspheres.

[0074] (3) Transfer the smooth-surfaced PEEK microspheres obtained in step (2) into a 50mL reactor, add 30mL of deionized water, heat at 1...

Embodiment 2

[0078] Using the preparation method provided in Example 1, the difference is that: the temperature of the hydrothermal reaction in step (2) is 170° C., and the time is 9 hours; PEEK microspheres with special topological morphology on the surface are obtained.

[0079] After testing, the static material mechanics maximum load point compressive strength of the PEEK microspheres with special topological morphology provided by Example 2 of the present invention is 6.1370 MPa.

[0080] ZEISS MERLIN field emission scanning electron microscope is used to characterize the PEEK microspheres with special topological morphology on the surface provided by Example 2 of the present invention; the results show that the PEEK microspheres with special topological morphology on the surface provided by Example 2 of the present invention have The honeycomb-like pore structure has a ravine morphology on the surface; the pore size of the honeycomb-like pore structure is 2 μm to 20 μm; the diameter o...

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Abstract

The invention provides a PEEK microballoon with a special topological shape on a surface, and a preparation method and application thereof. The interior of the PEEK microballoon is of a honeycomb-shaped sample hole structure, and extends to form the microballoon with a gully shape on the surface; and the hole size of the honeycomb-shaped sample hole structure is 1 to 20 microns. Compared with theprior art, the PEEK microballoon with the special topological shape on the surface, provided by the invention, has a preferable mechanical property, and simultaneously is good in filling effect; afterthe PEEK microballoon as a bone repair material is implanted into the body, on one hand, a good supporting role can be played, on the other hand, when large-area irregular bone defects are treated, apreferable filling effect can be achieved, and the PEEK microballoon is beneficial for the filling of the irregular bone defects; and moreover, the special topological shape on the surface of the PEEK microballoon is beneficial for cell proliferation and adhesion as well as growth factor loading, sufficient fusion with tissues can be promoted, the process of bone healing is quickened, and the process of pre-texturization is realized, so that wider application can be realized in tissue engineering bone repair materials.

Description

technical field [0001] The invention relates to the technical field of biomaterials, and more specifically, relates to a PEEK microsphere with a special topological shape on the surface, a preparation method and application thereof. Background technique [0002] In the field of orthopedics, bone defects caused by severe trauma, bone tumors, osteomyelitis and other reasons are very common, especially for large and irregular bone defects. What material and method to use for bone graft surgery is the current research hotspots. [0003] At present, bone repair materials commonly used in clinical practice include autologous bone, allogeneic bone, metal prosthesis and polymer synthetic materials, etc. Although autologous bone is an ideal material for bone defect repair, the process of bone extraction increases the trauma and pain of patients, and the source of bone supply is limited, making it difficult to shape and meet the requirements of large bone transplantation; allograft b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/50A61L27/56
CPCA61L27/18A61L27/50A61L27/56A61L2400/18A61L2430/02C08L61/16
Inventor 章培标纪庆明焦自学王宗良王宇李林龙王鹏
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI