Compound with chemotherapy and phototherapy anti-tumor effect and its preparation method and application

A technology of anti-tumor effects and compounds, applied in chemical instruments and methods, anti-tumor drugs, medical preparations containing active ingredients, etc., can solve strong toxic side effects, reduce anti-tumor effects of nucleoside drugs, and tumor cell line mutation and other problems, to achieve the effects of small toxic and side effects, good biological activity and efficacy, and stable molecular structure

Active Publication Date: 2020-08-14
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the anti-tumor drugs used clinically are nucleoside drugs, which have strong toxic and side effects due to the similarity in anti-tumor spectrum of nucleoside drugs
On the other hand, some tumor cell lines are prone to drug resistance to clinically used drugs, which will cause tumor cell lines to mutate easily and reduce the anti-tumor effect of nucleoside drugs
[0003] Dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant medicine have a good curative effect on the treatment of some tumors

Method used

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  • Compound with chemotherapy and phototherapy anti-tumor effect and its preparation method and application
  • Compound with chemotherapy and phototherapy anti-tumor effect and its preparation method and application
  • Compound with chemotherapy and phototherapy anti-tumor effect and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A compound with chemotherapy and phototherapy anti-tumor effects, the structural formula of the compound is:

[0032]

[0033] A preparation method of a compound having chemotherapy and phototherapy anti-tumor effects, comprising the following steps:

[0034] S1. Dissolve 9-anthracene formaldehyde and 4-methylthiosemicarbazide in absolute ethanol, then add glacial acetic acid, heat to reflux, cool and filter to obtain 9-anthracene-N 4 - methylthiosemicarbazide;

[0035] S2, the 9-anthracene-N 4 -Methylthiosemicarbazide, dichloro(pentamethylcyclopentadienyl) rhodium (III) dimer are dissolved in ethanol and mixed, and the solvent is removed by rotary evaporation to obtain a red solid, which is the anti-inflammatory drug with chemotherapy and phototherapy. Tumor compounds.

[0036] In the preparation method of the compound having chemotherapy and phototherapy anti-tumor effects, the heating and reflux time in S1 is 2.5 hours.

[0037] In the preparation method of th...

Embodiment 2

[0042] A preparation method of a compound having chemotherapy and phototherapy anti-tumor effects, comprising the following steps:

[0043] S1. Dissolve 9-anthracene formaldehyde and 4-methylthiosemicarbazide in absolute ethanol, then add glacial acetic acid, heat to reflux, cool and filter to obtain 9-anthracene-N 4 - methylthiosemicarbazide;

[0044] S2, the 9-anthracene-N 4 -Methylthiosemicarbazide, dichloro(pentamethylcyclopentadienyl) rhodium (III) dimer are dissolved in ethanol and mixed, and the solvent is removed by rotary evaporation to obtain a red solid, which is the anti-inflammatory drug with chemotherapy and phototherapy. Tumor compounds.

[0045] In the preparation method of the compound having chemotherapy and phototherapy anti-tumor effects, the heating and reflux time in S1 is 3.5 hours.

[0046] In the preparation method of the compound having chemotherapy and phototherapy anti-tumor effects, the mixing temperature in S2 is 25° C. and the time is 4 hours....

Embodiment 3

[0051] A preparation method of a compound having chemotherapy and phototherapy anti-tumor effects, comprising the following steps:

[0052] S1. Dissolve 9-anthracene formaldehyde and 4-methylthiosemicarbazide in absolute ethanol, then add glacial acetic acid, heat to reflux, cool and filter to obtain 9-anthracene-N 4 - methylthiosemicarbazide;

[0053] S2, the 9-anthracene-N 4 -Methylthiosemicarbazide, dichloro(pentamethylcyclopentadienyl) rhodium (III) dimer are dissolved in ethanol and mixed, and the solvent is removed by rotary evaporation to obtain a red solid, which is the anti-inflammatory drug with chemotherapy and phototherapy. Tumor compounds.

[0054] In the preparation method of the compound having chemotherapy and phototherapy anti-tumor effects, the heating and reflux time in S1 is 4.5 hours.

[0055] In the preparation method of the compound having chemotherapy and phototherapy anti-tumor effects, the mixing temperature in S2 is 30° C. and the time is 5 hours....

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Abstract

The invention discloses a compound with chemotherapy and phototherapy anti-tumor effects. The chemical name of the compound is monochloro-chloro-(9-anthracene-N4-methylthiosemicarbazide)-pentamethylcyclopentadienyl rhodium (III), and the structural formula of the compound is shown in the description. The compound has good inhibitory effects on human prostate cancer PC3 cells, human ovarian cancerSKOV3 cells, and high blood pressure, and can be used for preparing drugs for treating prostate cancer, ovarian cancer and hypertension.

Description

technical field [0001] The invention relates to the field of synthetic compound synthesis, in particular to a compound with chemotherapy and phototherapy anti-tumor effects. Background technique [0002] Cancer is one of the most important diseases that endanger human health, and there is still no effective treatment. At present, most of the antineoplastic drugs used clinically are nucleoside drugs, which have strong toxic and side effects due to the similarity in the antitumor spectrum of nucleoside drugs. On the other hand, some tumor cell lines are prone to drug resistance to clinically used drugs, which leads to mutations in tumor cell lines and reduces the anti-tumor effect of nucleoside drugs. [0003] Dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant medicine have good curative effect on some tumors. In this sense, the development of anti-tumor drugs that can overcome the drug resistance of tumor cell lines or have broad-spectrum activit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F17/02A61K31/555A61K41/00A61P35/00A61P9/12
CPCA61K31/555A61K41/0057A61P9/12A61P35/00C07F17/02
Inventor 李培源苏炜霍丽妮陈睿
Owner GUANGXI UNIV OF CHINESE MEDICINE
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