Titanium alloy implant with effects of resisting infection and promoting bone formation and preparation method thereof

A titanium alloy and implant technology, applied in the field of titanium alloy implants for anti-infection and promoting osteogenesis, can solve the problems of lack of blood supply, bacterial growth and adhesion, etc., achieve excellent antibacterial properties, promote interface integration, and reduce cells. toxic effects

Active Publication Date: 2019-03-12
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

[0003] However, after the titanium alloy material is implanted into the human body, compared with normal human tissue, its surface lacks blood supply, which is conducive to the growth and adhesion of bacteria, causing infection

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  • Titanium alloy implant with effects of resisting infection and promoting bone formation and preparation method thereof
  • Titanium alloy implant with effects of resisting infection and promoting bone formation and preparation method thereof

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Embodiment Construction

[0024] The technical solutions of the present invention will be further described below in conjunction with the drawings and embodiments.

[0025] The present invention also provides a preparation method of an anti-infection and osteogenesis-promoting titanium alloy implant, the method comprising:

[0026] Step 1, using titanium alloy implants or 3D printing titanium alloy implant body;

[0027] Step 2, perform alkali heat treatment on the surface of the titanium alloy implant body, and activate dopamine; the alkali heat treatment refers to treating the titanium alloy implant with 4M KOH in a hydrothermal kettle, 80°C, 90min; the dopamine Activation refers to soaking the alkali-heat-treated titanium alloy implant in 2 mg / mL dopamine solution for 24 hours;

[0028] Step 3, perform HA (hydroxyapatite, hydroxyapatite) grafting to cover the implant with HA, and perform dopamine activation again; the HA grafting refers to soaking the implant in 1 times simulated body fluid branch...

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Abstract

The invention discloses a titanium alloy implant with effects of resisting infection and promoting bone formation and a preparation method thereof. The preparation method comprises the following stepsof S1, preparing a titanium alloy implant body; S2, performing alkaline heat treatment on the surface of the titanium alloy implant body, and activating dopamine; S3, performing HA (hydroxyapatite) grafting, and activating the dopamine again; S4, under the room temperature environment, soaking the titanium alloy implant body treated in step 3 into 1 to 4 mM of silver nitrate solution for 0.5 to 8h, fetching out, airing, radiating by ultraviolet light for 0.5 to 2 h, and reducing, so as to obtain a nanometer Ag (silver) particle layer; S5, soaking the titanium alloy implant body treated in step 4 into 1 to 4 mg/ml of chitosan for 30 s to 5 min, and drying, so as to complete the preparation of the HA/Ag/Cs-loaded coating titanium alloy implant. Compared with the titanium alloy implant, theprepared HA/Ag/Cs-loaded coating titanium alloy implant has excellent antibacterial property, and can promote the bone formation and the integration of bone-prosthesis interface.

Description

technical field [0001] The invention relates to a medical implant, in particular to a titanium alloy implant for anti-infection and promoting osteogenesis. Background technique [0002] Titanium and its alloys have good mechanical properties and biocompatibility, and are currently the most widely used orthopedic implant materials. [0003] However, after the titanium alloy material is implanted into the human body, compared with normal human tissue, its surface lacks blood supply, which is conducive to the growth and adhesion of bacteria, causing infection. Infection is a disastrous complication after orthopedic implant surgery and is one of the leading causes of implant failure. According to reports, the probability of infection around the prosthesis after artificial joint replacement is 1-3%, and the infection rate of open femoral or tibial fractures treated with intramedullary nails is as high as 5%-10%. [0004] Therefore, there is an urgent need to prepare orthopedic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/32A61L27/30A61L27/50A61L27/54C23C18/14
CPCA61L27/06A61L27/306A61L27/32A61L27/50A61L27/54A61L2300/104A61L2300/404A61L2400/18A61L2420/02A61L2420/08A61L2430/02C23C18/14
Inventor 谢凯郝永强吴水林李浚周子傲郭煜
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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