Unlock instant, AI-driven research and patent intelligence for your innovation.

Functionalized mesoporous silicon-based tumor targeted transport and controlled release system and preparation method thereof

A tumor-targeting, mesoporous silicon technology, which is applied in the fields of anti-tumor drugs, capsule delivery, and pharmaceutical formulations, can solve the problems of inaccessible tumor site enrichment, difficulty penetrating tumor blood vessels, and large drug carrier size. Improve the effect of small drug loading

Active Publication Date: 2021-08-10
HUBEI UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing drug controlled release carrier research has made some progress, but there are still some problems: (1) In the research of nano-targeted carriers based on the tumor microenvironment, most of them are single-response carriers, which cannot give full play to their potential. The characteristics of different tumor microenvironment response substances are not conducive to the controlled release of drug carriers
(2) The drug carrier constructed with mesoporous silicon nanoparticles tends to aggregate in the body, which leads to the excessive size of the drug carrier, which is difficult to penetrate the tumor blood vessels and fails to achieve the purpose of enriching at the tumor site
(3) Research on the controlled release of mesoporous silicon drug carriers is currently limited to in vitro experiments and animal experiments. These results cannot fully and truly reflect the experimental conditions of the human body. Uncertain factors greatly limit its practical applicability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Functionalized mesoporous silicon-based tumor targeted transport and controlled release system and preparation method thereof
  • Functionalized mesoporous silicon-based tumor targeted transport and controlled release system and preparation method thereof
  • Functionalized mesoporous silicon-based tumor targeted transport and controlled release system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1. Preparation of thiol-functionalized mesoporous silicon nanoparticles (MSN-SH)

[0057] Accurately weigh 0.8g NaOH and add it to 480mL deionized water, then add 1.0g cetyltrimethylammonium bromide (CTAB) and dissolve it ultrasonically, stir vigorously and heat up to 80°C, 5.0mL tetraethyl orthosilicate ( TEOS) and 0.97 mL of 3-mercaptopropyltrimethoxysilane (MPTMS) were slowly added dropwise to the above solution, and the reaction was vigorously stirred at 80° C. for 2 h. After cooling to room temperature, the white solid was collected by centrifugation (9500r / min×8min), and ultrasonically cleaned several times with methanol and deionized water respectively, and the product was freeze-dried to obtain mesoporous silicon nanoparticles (CTAB @MSN-SH).

[0058] In order to remove the surfactant of mesoporous silicon nanoparticles, the extraction method under acidic conditions with methanol was used. Weigh 1.0g of CATB@MSN-SH and add it to 160mL of anhydrous methanol. Af...

Embodiment 2

[0076] 1. Preparation of thiol-functionalized mesoporous silicon nanoparticles (MSN-SH)

[0077] Accurately weigh 0.8g NaOH and add it to 480mL deionized water, then add 1.0g cetyltrimethylammonium bromide (CTAB) and dissolve it ultrasonically, stir vigorously and heat up to 80°C, 5.0mL tetraethyl orthosilicate ( TEOS) and 0.97 mL of 3-mercaptopropyltrimethoxysilane (MPTMS) were slowly added dropwise to the above solution, and the reaction was vigorously stirred at 80° C. for 2 h. After cooling to room temperature, the white solid was collected by centrifugation (9500r / min×8min), and ultrasonically cleaned several times with methanol and deionized water respectively, and the product was freeze-dried to obtain mesoporous silicon nanoparticles (CTAB @MSN-SH).

[0078] In order to remove the surfactant of mesoporous silicon nanoparticles, the extraction method under acidic conditions with methanol was used. Weigh 1.0g of CATB@MSN-SH and add it to 160mL of anhydrous methanol. Af...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention provides a functionalized mesoporous silicon-based tumor targeted transport and controlled release system and a specific preparation method thereof. The system has a two-layer core-shell structure, the inner layer is drug-loaded mesoporous silicon particles, and the outer layer is grafted with cyclopaste refined hyaluronic acid; using inorganic mesoporous silicon as the drug carrier, cyclodextrin hyaluronic acid was used to encapsulate the drug carrier, and according to the characteristics of the tumor microenvironment, a pH-sensitive reduction-sensitive drug carrier was constructed, making it It has the ability of stimulating-response controlled release of drugs and good biocompatibility, improving drug utilization and reducing toxic and side effects on normal tissues.

Description

technical field [0001] The invention relates to the field of drug controlled release, in particular to the field of a functionalized mesoporous silicon-based tumor targeted transport controlled release system and a specific preparation method thereof. Background technique [0002] According to the latest news released by the World Health Organization in February 2018, cancer has become the second leading cause of death in the world. In 2015, the number of cancer deaths has risen to 8.8 million. Therefore, it is urgent to vigorously develop cancer treatment on a global scale. [0003] At present, the main measures for treating cancer include surgery, radiation therapy, and chemical drug therapy. Due to the characteristics of easy metastasis of cancer, difficult surgery and easy recurrence after operation, compared with radiotherapy, chemotherapy has significant advantages in the treatment of solid tumors. The damage caused by the patient's immune system, a large number of ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/40A61K31/704A61K47/61A61K47/69A61P35/00
CPCA61K9/5161A61K31/704A61K47/61A61K47/6949A61P35/00
Inventor 李草罗毕矗卢金博
Owner HUBEI UNIV