Method for laser preparation of nano-drug preparation
A nano-medicine and laser technology, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of high-pressure homogeneous equipment, such as large loss, easy degradation, and drug stability, to ensure sterility state, uniform particle size, and the effect of saving sterilization steps
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Embodiment 1
[0048] Preparation of paclitaxel nanoparticles freeze-dried powder:
[0049] 600 mg of paclitaxel was placed in 50 mL of sterile aqueous solution to obtain suspension 1.
[0050] Separately prepare a saturated aqueous solution of citric acid, and filter through a 0.22 μm membrane to obtain 1000 mL of solution 2.
[0051] Then 1 g of mannitol was dissolved in 10 mL of aqueous solution, and filtered through a 0.22 μm membrane to obtain solution 3.
[0052] In a sterile room, pour solution 3 into suspension 1 to obtain suspension 4, and then drop solution 2 into suspension 4 to adjust its pH value to 3.0-5.0, and then dissolve the suspension with sterilized distilled water Dilute to 100mL.
[0053] Then put it into 10mL brown ampoule, and then put the ampoule in the laser nanometer, with Nd:YAG frequency doubled green solid-state laser as the light source, the radiation wavelength is 532nm, and the energy density is 80mJ / cm 2 , the radiation width is 15ns, the repetition rate ...
Embodiment 2
[0056] Preparation of etoposide nano freeze-dried agent:
[0057] Put 2.0 g of etoposide into about 50 mL of sterile aqueous solution to obtain suspension 1.
[0058] An acid solution with a weight concentration of 30% was also prepared and filtered through a 0.22 μm membrane to obtain 1000 mL of solution 2.
[0059] Then 0.5 g of D-trehalose was dissolved in 10 mL of aqueous solution, and filtered through a 0.22 μm membrane to obtain solution 3.
[0060] Pour solution 3 into suspension 1 in a sterile room to obtain suspension 4, and then drop solution 2 into suspension 4 to adjust its pH to 3.5-5.5, and then dissolve the suspension with sterilized distilled water Dilute to 100mL. Then put it into a 10mL brown ampoule, place the ampoule in a laser nanometer for radiation, then put it into a 10mL brown ampoule, put the ampoule in a laser nanometer, and use an ultraviolet XeCl excimer laser as a light source. The radiation wavelength is 351nm, and the energy density is 30mJ / c...
Embodiment 3
[0062] Preparation of itraconazole nanoparticles lyophilizate:
[0063] 1.0 g of sterile itraconazole was placed in approximately 50 mL of sterile aqueous solution to obtain suspension 1.
[0064] In addition, 1.0 g of D-sorbitol was dissolved in 10 mL of aqueous solution, and filtered through a 0.22 μm membrane to obtain 9.5 mL of solution 2.
[0065] Solution 2 was poured into suspension 1 in a sterile room to obtain suspension 3.
[0066] Then the suspension was made up to 100 mL with sterile distilled water. Then put it into 10mL brown ampoule, and then place the ampoule in the laser nanometer for radiation, with Nd:YAG triple frequency ultraviolet solid laser as the light source, the radiation wavelength is 355nm, and the energy density is 80mJ / cm 2 , the radiation width is 10ns, the repetition rate is 10Hz, and the drug nanosuspension with a particle size of 100nm is obtained, and the particle size distribution is shown in Figure 6 . Finally, the ampoule was pre-fro...
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