Preparation and application of casein-carboxymethyl chitosan glycosylation nanoparticles

A technology of carboxymethyl chitosan and casein, which is applied in the field of functional health food nanocapsules, can solve the problems of unstable EGCG properties and low bioavailability, and achieves excellent performance, improved grafting effect, and thermal stability. Good results
CN109480291APending Publication Date: 2019-03-19ZHEJIANG GONGSHANG UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG GONGSHANG UNIVERSITY
Publication Date
2019-03-19

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Abstract

The invention relates to a novel composite glycosylation modifying method. Casein and carboxymethyl chitosan are used as raw materials, and a copolymer high in grafting degree and good in heat stability is prepared, is applied to encapsulating of EGCG, and aims to improve the stability and slow release properties of EGCG. The specific method comprises the following steps of firstly performing polysaccharide graft modification on casein by a microwave wet method, then performing dry-method modification on primary wet-method products to obtain glycosylation products of which the grafting rate is80.5%, and loading and encapsulating the EGCG by a homogenizing method to obtain a ternary compound. The largest encapsulating rate of the compound on the EGCG is 79.68%, the reducing rate of resisting oxidation of the EGCG can be notably delayed during heat treatment and shelf life, the EGCG is slowly released in intestine and stomach liquid, the phenomenon of sudden release is effectively avoided, and the novel composite glycosylation modifying method can be widely applied to trade of foods, health-care products and the like.
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Description

technical field

[0001] The preparation of casein-carboxymethyl chitosan glycosylated nanoparticles and their application to loading and encapsulating EGCG belong to the technical field of functional health food nanocapsules. Background technique

[0002] Casein is the whole protein with the most abundant content and the highest nutritional value in milk, and the digestion and absorption rate of nutrients is extremely high. Casein molecules can self-assemble to form micelles in solution, and the structure is stable, making it very suitable as a carrier to transport various biological nutrients. However, the self-packaging behavior of casein is easily affected by the complex structure of nutrients and the delivery environment. Therefore, modified casein can endow proteins with artificially designed additional properties and improve the biological supply rate of nutrients.

[0003] The Maillard reaction is the reaction between the amino group on the protein and the carboxyl gr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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