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A magnetostrictive iron-gallium alloy that stimulates cell activity and rapidly degrades and its preparation method

A technology that rapidly degrades and stimulates cells. It is applied in metal processing equipment, additive manufacturing, transportation and packaging. It can solve the problems of slow degradation rate and poor cell activity, and achieve the effect of promoting proliferation and differentiation, low cost and good safety.

Inactive Publication Date: 2020-06-09
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of poor cell activity and slow degradation rate of iron-based medical materials, the present invention provides a magnetostrictive iron-gallium alloy that stimulates cell activity and rapidly degrades, and its preparation method and application

Method used

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  • A magnetostrictive iron-gallium alloy that stimulates cell activity and rapidly degrades and its preparation method
  • A magnetostrictive iron-gallium alloy that stimulates cell activity and rapidly degrades and its preparation method
  • A magnetostrictive iron-gallium alloy that stimulates cell activity and rapidly degrades and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Using gallium powder (purity>99%, particle size 40-100nm) and iron powder (purity>99%, particle size 40-80μm) as raw materials, weigh the gallium powder and iron powder in the ball mill according to the atomic ratio of 0.2:0.8 In the process, under the protective atmosphere of high-purity argon with a purity ≥ 99.999%, the set rotation speed is 240 rad / min, and the ball milling time is 3 h to obtain iron-gallium mixed powder. Using the above mixed powder as raw material, pass through a high-purity argon protective atmosphere with a purity ≥ 99.999%, and prepare iron- gallium alloy.

[0029] The test found that the gallium element was solid-dissolved in the iron grains, and the aggregation of gallium was not detected, and the magnetostriction coefficient of the alloy reached 265×10 -6; Under the magnetic field, the activity of MG63 cells cultivated on the iron-gallium alloy increased by 72% compared to iron ( figure 1 ), while the degradation of Fe-Ga alloy is signific...

Embodiment 2

[0031] Using gallium powder (purity>99%, particle size 40-100nm) and iron powder (purity>99%, particle size 40-80μm) as raw materials, weigh the gallium powder and iron powder in the ball mill according to the atomic ratio of 0.1:0.9 In the process, under the protective atmosphere of high-purity argon with a purity ≥ 99.999%, the set rotation speed is 240 rad / min, and the ball milling time is 3 h to obtain iron-gallium mixed powder. Using the above mixed powder as raw material, pass through a high-purity argon protective atmosphere with a purity ≥ 99.999%, and prepare iron- gallium alloy.

[0032] The test found that the gallium element was solid-dissolved in the iron grains, and the aggregation of gallium was not detected, and the magnetostriction coefficient of the alloy reached 165×10 -6 Under the action of magnetic field, the activity of MG63 cells cultured on Fe-Gallium alloy increased by 40% compared with that of Fe-Gallium alloy. At the same time, the degradation of Fe...

Embodiment 3

[0034] Using gallium powder (purity>99%, particle size 40-100nm) and iron powder (purity>99%, particle size 40-80μm) as raw materials, weigh the gallium powder and iron powder in the ball mill according to the atomic ratio of 0.2:0.8 In the process, under the protective atmosphere of high-purity argon with a purity ≥ 99.999%, the set rotation speed is 240 rad / min, and the ball milling time is 3 h to obtain iron-gallium mixed powder. Using the above-mentioned mixed powder as raw material, pass through a high-purity argon protective atmosphere with a purity ≥ 99.999%, and prepare iron- gallium alloy.

[0035] The test found that most of the gallium element was dissolved in the iron grains, and a small amount of gallium was detected at the grain boundary. The magnetostriction coefficient of the alloy reached 172×10 -6 ; Under the action of magnetic field, the activity of MG63 cells cultured on Fe-Gallium alloy increased by 51% compared with that of Fe-Gallium alloy. At the same ...

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Abstract

The invention belongs to the technical field of medical metal preparation, in particular to a magnetostrictive iron-gallium alloy that stimulates cell activity and rapidly degrades and a preparation method thereof. The Fe-Gallium alloy designed and prepared by the present invention has excellent magnetostrictive properties, and can convert magnetic field energy into physical deformation under the action of a magnetic field. Proliferation of bone cells, thereby speeding up the repair of bone defects; on the other hand, using the difference in magnetostrictive properties between the alloy matrix and degradation products to promote the cracking and shedding of the degradation product layer from the matrix, thereby accelerating the penetration of body fluids into the alloy , so as to realize the rapid degradation of the alloy. The magnetostrictive iron-gallium alloy and its preparation method proposed by the invention can simultaneously solve the problems of poor cell activity and slow degradation of conventional iron-based implant materials, thus promoting its application in the field of bone defect repair.

Description

technical field [0001] The invention belongs to the technical field of medical metal preparation, in particular to a magnetostrictive iron-gallium alloy that stimulates cell activity and rapidly degrades and a preparation method thereof. Background technique [0002] At present, the commonly used medical metal materials mainly include iron and its alloys, titanium and its alloys, among which iron and its alloys account for about half of the market. Compared with titanium and its alloys, iron can be degraded in the physiological environment and has unique advantages in repairing bone defects as an implant. However, due to the high standard potential (-0.44V), the degradation rate of iron in the human body is very slow. , it has been reported that after 12 months of implantation, most of the iron implants still remain at the implantation site, unable to make enough space for new tissue growth; more importantly, due to the limited ability of cell proliferation and differentiati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C38/00C22C33/02B22F1/00B22F9/04B22F3/105
CPCC22C33/0278C22C38/002B22F9/04B22F2009/043B22F2999/00C22C2202/02B22F10/00B22F1/052B22F10/28B22F10/36B22F10/32B22F2201/11Y02P10/25
Inventor 高成德帅词俊王丽
Owner CENT SOUTH UNIV