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Preparation method of xanthan gum/chitosan nanofiber membrane

A technology of chitosan nano and xanthan gum, which is applied in fiber treatment, filament/thread forming, textile and papermaking, etc., to achieve the effect of reducing adhesion performance, improving release persistence, and easy-to-understand preparation method

Active Publication Date: 2019-03-19
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems in the prior art, the present invention provides a preparation method of xanthan gum / chitosan nanofiber membrane, which solves the limitations of the existing biologically active compounds in the use process. Fibrous membrane encapsulates the structure of curcumin to enhance the sustained release

Method used

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  • Preparation method of xanthan gum/chitosan nanofiber membrane
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  • Preparation method of xanthan gum/chitosan nanofiber membrane

Examples

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Embodiment 1

[0031] A preparation method of xanthan gum / chitosan nanofiber membrane includes the following steps:

[0032] (1) Preparation of electrospinning solution:

[0033] First, 1 g of xanthan gum (Mw=20 million) and 2 g (Mw=200,000) of chitosan were dissolved in 100 mL of formic acid solution, and then magnetically vigorously stirred at room temperature for 20 hours to obtain a viscoelastic gel solution. Then 1g of curcumin was added to the above gel solution, mixed and stirred for 20 minutes to dissolve to obtain a homogeneous solution. The mixed solution was ultrasonically treated with a 1000W ultrasonic instrument at 40% intensity for 10 minutes to prepare a xanthan gum-chitosan-curcumin nanocomposite solution.

[0034] (2) Manufacturing of xanthan gum / chitosan nanofiber membrane:

[0035] The solution for preparing the composite material was injected into a 10 mL plastic syringe with a 21-G stainless steel needle and connected to the syringe pump. The spinning voltage was 20KV, the ad...

Embodiment 2

[0038] A preparation method of xanthan gum / chitosan nanofiber membrane includes the following steps:

[0039] (1) Preparation of electrospinning solution:

[0040] First, 0.5g of xanthan gum (Mw=10 million) and 4g (Mw=400,000) of chitosan were dissolved in 100mL of a mixed solution of formic acid and phosphoric acid, and then magnetically stirred vigorously at room temperature for 40 hours to obtain a viscoelastic gel solution . Then 4 g of curcumin was added to the gel solution, mixed and stirred for 60 minutes to dissolve to obtain a homogeneous solution. The mixed solution was ultrasonically treated with a 1000W ultrasonic instrument at 40% intensity for 30 minutes to prepare a xanthan gum-chitosan-curcumin nanocomposite solution.

[0041] (2) Manufacturing of xanthan gum / chitosan nanofiber membrane:

[0042] The solution for preparing the composite material was injected into a 10 mL plastic syringe with a 21-G stainless steel needle and connected to the syringe pump. The spinni...

Embodiment 3

[0044] A preparation method of xanthan gum / chitosan nanofiber membrane includes the following steps:

[0045] (1) Preparation of electrospinning solution:

[0046] First, 0.8g xanthan gum (Mw=5 million) and 10g (Mw=500,000) chitosan were dissolved in 100mL of formic acid and phosphoric acid mixed solution, and then magnetically vigorously stirred at room temperature for 30 hours to obtain a viscoelastic gel solution . Then, 5 g of curcumin was added to the above gel solution, mixed and stirred for 10 minutes to dissolve to obtain a homogeneous solution. The mixed solution was ultrasonically treated with a 1000W ultrasonic instrument at 40% intensity for 5 minutes to prepare a xanthan gum-chitosan-curcumin nanocomposite solution.

[0047] (2) Manufacturing of xanthan gum / chitosan nanofiber membrane:

[0048] The solution for preparing the composite material was injected into a 10 mL plastic syringe with a 21-G stainless steel needle and connected to the syringe pump. The spinning vo...

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Abstract

The invention discloses a preparation method of a xanthan gum / chitosan nanofiber membrane. The method comprises the following steps of step 1, dissolving the xanthan gum and chitosan in an acidic solution, vigorously stirring at room temperature for 20-40 hours, and obtaining a viscoelastic gel solution; step 2, adding curcumin to the viscoelastic gel solution, and mixing and stirring to dissolvefor 10-60 minutes to obtain a uniform mixed solution; step 3, placing the mixed solution into an ultrasonic unit for ultrasonic treatment 5-30 min, and obtaining xanthan gum-chitosan-curcumin nanocomposite solution; step 4, injecting the xanthan gum-chitosan-curcumin nanocomposite solution into a 10 mL plastic syringe through a 21-G stainless steel needle, and carrying out an electrospinning reaction by connecting the syringe with a syringe pump to obtain the nanofiber membrane; step 5, separating the nanofiber membrane, and drying at room temperature for 10-30 hours to obtain the xanthan gum / chitosan nanofiber membrane. The method encapsulates the structure of curcumin by the xanthan gum / chitosan nanofiber membrane to enhance release persistence.

Description

Technical field [0001] The invention belongs to the technical field of drug carrier biomaterials, and in particular relates to a method for preparing xanthan gum / chitosan nanofiber membrane. Background technique [0002] Curcumin is a phenolic compound whose medicinal properties are considered antioxidants, antibacterial agents, anti-inflammatory agents, tumorigenesis and metastasis inhibitors. However, due to its hydrophobicity and subsequent poor bioavailability, new technologies need to be studied as delivery vehicles. [0003] Effective delivery of hydrophobic biologically active substances requires proper encapsulation to overcome related problems such as low solubility and instability in aqueous body fluids, and limited bioavailability. Electrohydrodynamics (electrospinning and electrospray) methods have been extensively studied due to their high encapsulation efficiency, low process temperature and the use of a wide range of food biological activities and shell components. ...

Claims

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Application Information

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IPC IPC(8): D04H1/728D01D5/00
CPCD01D5/003D04H1/728
Inventor 黄建祥许杉杉赵亮亮孔海磊
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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