Preparation of a class of injectable hydrogels with cohesion-enhancing properties

A technology for injecting water and properties, which is applied in the field of medical biomaterials and can solve problems such as gel cohesion enhancement
CN109503864BActive Publication Date: 2021-06-29SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD
Publication Date
2021-06-29

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Abstract

The present invention provides a method for the preparation of a class of injectable gels having cohesion-enhancing properties after autoclaving. The chemically cross-linked amide bond in the system makes the gel have a strong ability to resist short-term high-temperature and high-pressure damage, and the free carboxyl and amino groups will form ionic bonds through electrostatic attraction due to the slow movement of the molecular chain, making the system sterilized. After a period of time, the dynamic viscosity continued to increase, and finally reached a plateau and exceeded the dynamic viscosity before sterilization. The enhanced cohesion endows the gel with good stability, which can maintain its shape for a long time without dispersion in a liquid environment. A suitable degree of crosslinking confers injectability to the gel. The enhanced cohesion and injectability make the gel system have strong application prospects in the field of biomedicine, especially in the direction of implantation in vivo, such as drug loading, filling, tissue repair, etc.
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Description

technical field

[0001] The invention relates to the field of medical biomaterials, in particular to the preparation of a type of injectable hydrogel, which is characterized in that it has cohesive enhancement properties after being sterilized by high pressure steam, that is, the dynamic viscosity after sterilization will increase after a period of time. before sterilization. Background technique

[0002] Injectable hydrogel refers to a type of hydrogel that is fluid and can be applied by injection, and can be used in the field of minimally invasive applications. For example, a drug can be encapsulated into an injectable drug carrier, a bare stent can be injected, or a growth factor or cell can be encapsulated into an injectable composite scaffold. There are numerous literature and patents reporting such hydrogel systems.

[0003] Wu (Zhang, W.; Jin, X.; Li, H.; Zhang, R.-r.; Wu, C.-w., Injectable and bodytemperature sensitive hydrogels based on chitosan and hyaluronic acid...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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