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SEBS-based granules, preparation method thereof, extrusion membrane for infusion apparatus and infusion apparatus

A technology of base granules and granules, which is applied in its preparation, extruded film for infusion sets and infusion sets, SEBS base granules, can solve the problems of non-environmental protection, complicated operation, high cost, etc.

Active Publication Date: 2019-03-22
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are certain defects in the above schemes. The method for preparing the infusion set is blending modification, which needs to add a series of auxiliary agents to achieve the effect of inhibiting drug adsorption. This type of method is costly and complicated to operate, and adding a series of auxiliary The agent may react with the drug, the effect of inhibiting the adsorption is not good, and it does not meet the requirements of environmental protection

Method used

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  • SEBS-based granules, preparation method thereof, extrusion membrane for infusion apparatus and infusion apparatus
  • SEBS-based granules, preparation method thereof, extrusion membrane for infusion apparatus and infusion apparatus
  • SEBS-based granules, preparation method thereof, extrusion membrane for infusion apparatus and infusion apparatus

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preparation example Construction

[0051] The present invention also provides a method for preparing SEBS-based pellets described in the above technical solution, comprising:

[0052] a) melting and blending the raw materials to obtain a blend;

[0053] b) extruding the blend into pellets to obtain SEBS-based pellets.

[0054] Wherein, the types and ratios of the components of the raw materials are consistent with those described in the above-mentioned technical solution, and will not be repeated here.

[0055] In the present invention, each raw material is preferably dried first before melt blending. The temperature for drying the raw materials is preferably 40-120°C, more preferably 50-80°C; the drying time is preferably 2-12 hours, more preferably 4-8 hours. After the raw materials are dried, they are preferably further mixed, and after uniform mixing, a mixed material is obtained.

[0056] After the mixture is obtained, the mixture is melt-blended to obtain a blend. The temperature of the melt-blending ...

Embodiment 1

[0063] 1.1 Material preparation

[0064] Weigh 70g of SEBS (brand YH506), 20g of dopamine, and 10g of vitamin E, dry in an oven at 80°C for 24h and mix well; then put it into an internal mixer for melt blending, the temperature of melt blending is 180°C, and the time is 10min , and the rotation speed was 100 rpm / min to obtain a blend. Put the obtained blend into a granulator to extrude and granulate to obtain SEBS-based pellets.

[0065] Dry the obtained SEBS-based pellets in an oven at 80°C for 24 hours, and then add them to a single-screw extruder with a head temperature of 160-200°C, a barrel temperature of 180-190°C, a residence time of 10 minutes, and extrude Pull the tube to obtain an infusion catheter with a diameter of 4 mm (denoted as sample S1). The preparation process of embodiment 1 is as figure 1 as shown, figure 1 Be the preparation flowchart of embodiment 1.

[0066] Preparation of control samples:

[0067] Only 70 g of SEBS was weighed, and an infusion ca...

Embodiment 2

[0075] 1.1 Material preparation

[0076] Weigh SEBS (brand name is G1652) 60g, 25g of dopamine, 15g of vitamin E, dried in an oven at 80°C for 24h and then mixed; then put into an internal mixer for melt blending, the temperature of melt blending is 180°C, the time is 10min, and the speed is 100rpm / min , to obtain a blend. Put the obtained blend into a granulator to extrude and granulate to obtain SEBS-based pellets.

[0077] Dry the obtained SEBS-based pellets in an oven at 80°C for 24 hours, and then add them to a single-screw extruder with a head temperature of 160-200°C, a barrel temperature of 180-190°C, a residence time of 10 minutes, and extrude Pull the tube to obtain an infusion catheter with a diameter of 4 mm (denoted as sample S2).

[0078] 1.2 Material adsorption test

[0079] According to the test process of Example 1, the adsorption test of the obtained sample S2 was carried out, and the results showed that within 60 minutes, the adsorption rate of the samp...

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Abstract

The invention provides SEBS-based granules, a preparation method thereof, an extrusion membrane for an infusion apparatus and the infusion apparatus. The SEBS-based granules provided by the inventionare prepared by performing blending and granulation on the following raw materials in parts by weight: 50-100 parts of SEBS, 0-40 parts of dopamine, 0-40 parts of SEBS-g-Ma and 2-30 parts of vitamin E-based compound, wherein the vitamin E-based compound is selected from one or more of vitamin E and vitamin E derivatives, and the contents of the dopamine and the SEBS-g-Ma are not 0 at the same time. For the SEBS-based granules provided by the invention, by taking the SEBS as a basic material, the granules are prepared by matching the SEBS with the dopamine, the SEBS-g-Ma and the vitamin E-basedcompound according to a certain ratio, and the obtained material can effectively inhibit adsorption on butyphthalide and alleviates the adsorption phenomenon of an SEBS infusion apparatus to the butyphthalide; and in addition, the granules are simple in components without various complex auxiliaries, is low in cost and further avoids the risk of generating the side effect with a drug.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a SEBS-based granular material, a preparation method thereof, an extruded film for an infusion set and an infusion set. Background technique [0002] According to statistics, the number of deaths due to acute ischemic stroke in my country reaches 1.5 million every year, and it is increasing year by year. Intravenous injection of butylphthalide and sodium chloride injection is currently a more commonly used solution. The infusion set is a basic tool for intravenous injection. Common infusion sets on the market include polyethylene infusion set, polyvinyl chloride infusion set, polypropylene infusion set, etc., but these have different degrees of adsorption to butylphthalide, and these materials Less stable. [0003] In recent years, styrene-based thermoplastic elastomer (TPE) has attracted the attention of many researchers due to its good aging resistance, thermal stabi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L53/02C08L51/00C08K5/1545C08K5/17
CPCC08L53/025C08L51/006C08K5/1545C08K5/17
Inventor 姜伟金晶韩媛媛崔杰孙彬
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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