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Application of inonotus obliquus alcohol extract to preparation of drug/health-protection product for treating/preventing hyperuricemia related disease

A technology of Inonotus obliquus and Inonotus obliquus is applied in the directions of skeletal diseases, drug combinations, pharmaceutical formulations, etc., and can solve the problems such as the lack of involvement in anti-hyperuricemia, and achieve a significant uric acid-lowering effect, less side effects, Improve the effect of large side effects

Inactive Publication Date: 2019-03-26
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its anti-hyperuricemia has not been involved

Method used

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  • Application of inonotus obliquus alcohol extract to preparation of drug/health-protection product for treating/preventing hyperuricemia related disease
  • Application of inonotus obliquus alcohol extract to preparation of drug/health-protection product for treating/preventing hyperuricemia related disease
  • Application of inonotus obliquus alcohol extract to preparation of drug/health-protection product for treating/preventing hyperuricemia related disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Guangdong Yuewei Edible Fungus Technology Co., Ltd. provided and identified Inonotus obliquus samples, and the voucher specimen (YW20170703-IO) was deposited in Guangdong Institute of Microbiology. After taking 100g of Inonotus obliquus to powder (particle size less than 5mm) using a powdering machine, use 2L ethanol to extract at 65°C for 3 hours for a total of three times. After the extracts were combined, concentrated by rotary evaporation and lyophilized to obtain an ethanol extract of Inonotus obliquus (yield: 4.87 g; yield: 4.8%).

Embodiment 2

[0047] Active substance analysis and component analysis of the ethanol extract of Example 1

[0048] The fingerprint of the extract was determined by HPLC ( figure 1 ), and betulin alcohol, a characteristic component of Inonotus obliquus, was used as a control (Figure 2). After comparison, the characteristic peak of betulin in the extract appeared at 52 min ( figure 1 ), and the retention time of the betulin alcohol control ( figure 2 ) Are consistent, and the results show that the extract is an Inonotus obliquus extract. Among them, the chromatographic conditions are: Agilent1200HPLC; Waters Atlantis T3RP-C18 column; 5μm, 250mm×4.6mm; 1.0ml / min flow rate; elution solvent is methanol (0.1% formic acid, A) and deionized water; elution procedure 0min(10%A)→50min(100%A)→70min (100%A)→71min(10%A)→83min(10%A); detection wavelength is 280nm; column temperature is 30℃; sample amount is 10μl. The result is figure 1 with figure 2 Shown.

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Abstract

The invention relates to application of an edible fungus extract in the aspect of a drug / health-protection product, and particularly relates to application of an inonotus obliquus alcohol extract to the preparation of a drug / health-protection product for treating / preventing a hyperuricemia related disease. The invention discloses that the inonotus obliquus ethanol extract has an obvious uric aciddecreasing effect, further, is few in side effect, can be used for preparing a drug for relieving the symptom of a gout disease, and is used for providing a novel direction for improving the phenomenon that a drug for the gout disease is great in side effect at present.

Description

Technical field [0001] The present invention relates to the application of an edible fungus extract in medicine / health products, in particular to the application of an alcohol extract of Inonotus obliquus in preparing medicine / health products for treating / preventing diseases related to hyperuric acid. Background technique [0002] Inonotus obliquus is a white rot fungus that is parasitic on birch trees throughout Eurasia. It is an edible fungus and has been used since the 12th century to treat cerebrovascular diseases, diabetes, and stomach. Traditional medicine for various diseases such as intestinal diseases. Nowadays, modern medical research has confirmed that it can effectively treat hyperglycemia, cancer, inflammation and other diseases, especially for metabolic diseases. Among them, the triterpenoids, polysaccharides, polyphenols and melanin that have been isolated and identified have anti-tumor, anti-inflammatory, anti-oxidant, hypoglycemic activity, immune regulation and...

Claims

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Application Information

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IPC IPC(8): A61K36/07A61P19/06
CPCA61K36/07A61K2236/333A61K2236/51A61P19/06
Inventor 雍天乔梁丹灵谢意珍
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY