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SEBS based composite membrane, preparation method of SEBS based composite membrane and infusion apparatus

A technology of composite film and infusion tube, which is applied in the field of medical materials, can solve the problems of poor adsorption inhibition, non-environmental protection, and complicated operation, and achieve the effects of improving adsorption phenomenon, low cost, and avoiding side reactions

Active Publication Date: 2019-03-26
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are certain defects in the above schemes. The method for preparing the infusion set is blending modification, which needs to add a series of auxiliary agents to achieve the effect of inhibiting drug adsorption. This type of method is costly and complicated to operate, and adding a series of auxiliary The agent may react with the drug, the effect of inhibiting the adsorption is not good, and it does not meet the requirements of environmental protection

Method used

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  • SEBS based composite membrane, preparation method of SEBS based composite membrane and infusion apparatus
  • SEBS based composite membrane, preparation method of SEBS based composite membrane and infusion apparatus
  • SEBS based composite membrane, preparation method of SEBS based composite membrane and infusion apparatus

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preparation example Construction

[0055] The present invention also provides a method for preparing the SEBS-based composite membrane described in the above-mentioned technical scheme, comprising the following steps:

[0056] a) soaking the SEBS substrate in a dopamine solution and drying it to obtain a dopamine-modified SEBS substrate;

[0057] b) soaking the dopamine-modified SEBS substrate in a retinoid solution and drying to obtain a SEBS-based composite membrane.

[0058] According to the present invention, the SEBS base material is first soaked in the dopamine solution and then dried to obtain the dopamine-modified SEBS base material.

[0059] In the present invention, the thickness of the SEBS substrate is not particularly limited, and it can be a film, sheet or plate, etc., that is, the present invention can construct a composite coating on the surface of various required SEBS substrates. The present invention has no special limitation on the source of the SEBS substrate, it can be a general commercia...

Embodiment 1

[0075] 1.1 Sample preparation

[0076] Prepare a 2wt% SEBS / toluene solution, stir overnight at room temperature, and after standing for 6 hours, take 100 μL SEBS / toluene solution and evenly drop it on the QCM-D gold chip, spin coat it at 5000 rpm for 20 seconds with a spin coater, and place it in an oven at 40 °C After drying for 3 hours, a SEBS film was formed on the QCM-D gold chip; three copies were made in parallel according to the above process, labeled S1-1, S1-2 and S1-3 respectively.

[0077] Samples S1-2 and S1-3 were respectively immersed in dopamine / Tris-HCl solution, wherein the concentration of dopamine was 5 mg / mL, and the pH of Tris-HCl buffer was 8.5; soaked for 12 hours at room temperature, and washed three times with deionized water , blown dry with nitrogen (vacuum degree is -0.05MPa, temperature is 25°C), and a polydopamine layer is formed on the surface of the SEBS film.

[0078] Take the sample labeled S1-3 and continue to put it into 200μg / mL vitamin E ...

Embodiment 2

[0086] 1.1 Sample preparation

[0087] Prepare a 2wt% SEBS / toluene solution, stir overnight at room temperature, and after standing for 6 hours, take 100 μL SEBS / toluene solution and evenly drop it on the QCM-D gold chip, spin coat it at 5000 rpm for 20 seconds with a spin coater, and place it in an oven at 40 °C Dry for 3 hours to form a SEBS film on the QCM-D gold chip; make two copies in parallel according to the above process, labeled S2-1 and S2-2 respectively.

[0088] Samples S2-1 and S2-2 were respectively immersed in dopamine / Tris-HCl solution, wherein the concentration of dopamine was 5 mg / mL, and the pH of Tris-HCl buffer was 8.5; soaked at room temperature for 12 hours, rinsed three times with deionized water , blown dry with nitrogen (vacuum degree is -0.05MPa, temperature is 25°C), and a polydopamine layer is formed on the surface of the SEBS film.

[0089] Continue to put samples S2-1 and S2-2 into different concentrations of vitamin E derivatives (vitamin E po...

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Abstract

The invention provides a SEBS based composite membrane, a preparation method of the SEBS based composite membrane and an infusion apparatus. The SEBS based composite membrane provided by the inventioncomprises an SEBS substrate layer, a polydopamine layer and a vitamer E layer, wherein the polydopamine layer is compounded on the surface of the SEBS substrate layer; the vitamer E layer is compounded at the surface of the polydopamine layer; raw materials for forming the vitamer E layer are selected from one or several kinds of materials in vitamin E derivatives. The polydopamine layer and thevitamer E layer are sequentially arranged at the surface of the SEBS substrate layer; the obtained material can effectively inhibit the butylphenyl phthaleine adsorption; the adsorption phenomenon ofthe SEBS infusion apparatus on butylphenyl phthaleine is greatly avoided; the medicine utilization rate can be improved; the economic burden of patients can be reduced; in addition, the composition ofthe SEBS based composite membrane provided by the invention is simple; various kinds of complicated auxiliary agents are not needed; the cost is low; the risk of generating side reaction with medicine is also avoided.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a SEBS-based composite membrane, a preparation method thereof and an infusion set. Background technique [0002] According to statistics, the number of deaths due to acute ischemic stroke in my country reaches 1.5 million every year, and it is increasing year by year. Intravenous injection of butylphthalide and sodium chloride injection is currently a more commonly used solution. The infusion set is a basic tool for intravenous injection. Common infusion sets on the market include polyethylene infusion set, polyvinyl chloride infusion set, polypropylene infusion set, etc., but these have different degrees of adsorption to butylphthalide, and these materials Low stability and high cost. [0003] In recent years, styrene-based thermoplastic elastomer (TPE) has attracted the attention of many researchers due to its good aging resistance, thermal stability, and high transp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08L53/02A61M5/14
CPCA61M5/14C08J7/16C08J2353/02C08J2479/04
Inventor 姜伟金晶韩媛媛崔杰孙彬
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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