Dinitolmide solution and preparation method thereof

A technology of dinitramide and solution, which is applied in the direction of medical formula, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of single administration route and the effect of Eimeria heap-type Poor, inconvenient and other problems, to achieve the effect of stable drug effect, easy absorption and performance improvement

Inactive Publication Date: 2019-03-29
广东新科农生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dinitramine has a good control effect on chicken poisoning, tenderness, Brucella, and Eimeria giga, especially the most pathogenic Eimeria in the small intestine, but this product has the best effect on heap Eimeria type less effective
At present, there is only dinitramide premix on the market, and the route of administration is single, which is inconvenient

Method used

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  • Dinitolmide solution and preparation method thereof
  • Dinitolmide solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A dinitramide solution, comprising the following raw materials in parts by weight: 10 parts of dinitramide, 75 parts of polyethylene glycol-335075 parts, 5 parts of suspending agent, 1 part of eucalyptus oil, 8 parts of stabilizer, and preservative 3 parts, 4 parts of surfactant.

[0021] Wherein, the suspending agent is composed of diatomite, polyvinylpyrrolidone and polyvinyl alcohol with a mass ratio of 1:1:2; the stabilizer is composed of propylene glycol, glycerin and 0.2 % carboxymethyl cellulose; the preservative is composed of thimerosal and boric acid with a mass ratio of 2:1; the surfactant is composed of poloxamer 188, carbomer and carbomer with a mass ratio of 2:1:3 Tween-80 composition.

[0022] A preparation method of dinitramide solution, comprising the following steps:

[0023] 1) Weigh the amount of dinitramine in the formula and add it to polyethylene glycol-3350, stir and dissolve it with a FSH-II high-speed homogenizer at a speed of 7000 rpm to pre...

Embodiment 2

[0027] A dinitramide solution, comprising the following raw materials in parts by weight: 20 parts of dinitramide, 20 parts of polyethylene glycol-335095 parts, 10 parts of suspending agent, 3 parts of eucalyptus oil, 13 parts of stabilizer, preservative 6 parts, 8 parts of surfactant.

[0028] Wherein, the suspending agent is composed of diatomite, polyvinylpyrrolidone and polyvinyl alcohol with a mass ratio of 1:1:2; the stabilizer is composed of propylene glycol, glycerin and 0.2 % carboxymethyl cellulose; the preservative is composed of thimerosal and boric acid with a mass ratio of 2:1; the surfactant is composed of poloxamer 188, carbomer and carbomer with a mass ratio of 2:1:3 Tween-80 composition.

[0029] A preparation method of dinitramide solution, comprising the following steps:

[0030] 1) Weighing the amount of dinitramine in the formula and adding it to polyethylene glycol-3350, stirring and dissolving with a FSH-II high-speed homogenizer at a speed of 9000 rp...

Embodiment 3

[0034] A dinitramide solution, comprising the following raw materials in parts by weight: 14 parts of dinitramide, 80 parts of polyethylene glycol-335080, 7 parts of suspending agent, 2 parts of eucalyptus oil, 9 parts of stabilizer, preservative 4 parts, 4 parts of surfactant.

[0035] Wherein, the suspending agent is composed of diatomite, polyvinylpyrrolidone and polyvinyl alcohol with a mass ratio of 1:1:2; the stabilizer is composed of propylene glycol, glycerin and 0.2 % carboxymethyl cellulose; the preservative is composed of thimerosal and boric acid with a mass ratio of 2:1; the surfactant is composed of poloxamer 188, carbomer and carbomer with a mass ratio of 2:1:3 Tween-80 composition.

[0036] A preparation method of dinitramide solution, comprising the following steps:

[0037] 1) Weigh the amount of dinitramine in the formula and add it to polyethylene glycol-3350, stir and dissolve it with a FSH-II high-speed homogenizer at a speed of 8000 rpm to prepare liqu...

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Abstract

The present invention discloses a dinitramine solution. The dinitramine solution comprises the following raw materials in parts by weight: 10-20 parts of dinitramine, 75-95 parts of polyethylene glycol-3350, 5-10 parts of a suspending agent, 1-3 parts of eucalyptus oil, 8-13 parts of a stabilizer, 3-6 parts of a preservative and 4-8 parts of a surfactant. The present invention also discloses a preparation method of the dinitramine solution. The polyethylene glycol-3350 is use and can better dissolve dinitramine. Besides, quantitative ratios of the suspending agent, eucalyptus oil, stabilizer,preservative and surfactant are added, so that the prepared dinitramine solution is obviously improved in performances and easy to absorb, drug effects can be fully utilized, and the dinitramine solution can be stored for a long time and is stable in the drug effects and favorable for popularization and application.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a dinitramide solution and a preparation method thereof. Background technique [0002] Dinitramide is a nitrobenzamide compound, which has been widely used in veterinary clinics in my country. It is an anticoccidial drug with both preventive and therapeutic effects. Dinitramide mainly acts on the first generation of schizonts, and also has an inhibitory effect on the sporozoite formation of oocysts. The anticoccidial mechanism of nitrobenzamide compounds is not clear yet. After oral administration and absorption, dinitramide is rapidly metabolized in the animal body, and the residual amount in chicken meat is less than 0.1 mg / kg within 24 hours of drug withdrawal. Dinitramine has a good control effect on chicken poisoning, tenderness, Brucella, and Eimeria giga, especially the most pathogenic Eimeria in the small intestine, but this product has the best effect on heap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K31/166A61P33/02
CPCA61K9/08A61K31/166A61K47/10A61P33/02
Inventor 杨慧李青青李东玲胡彬尧永胜李志澎
Owner 广东新科农生物科技有限公司
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