Method for preparing hop whitening extract

A technology for hops and extracts, applied in the field of preparation of hop whitening extracts, can solve the problems of not involving hops whitening functional components, not involving hops xanthohumol extract whitening functional components and efficacy verification, etc. The effect of inhibiting transport

Inactive Publication Date: 2019-04-02
陕西佰瑞衡健康科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Chinese patent application CN200610104746.2 "Method for extracting and separating hop extract and hop essential oil from hops" involves the extraction method of hop extract and essential oil, but does not involve the extraction of hop whitening functional components
[0007] Chinese patent application CN200480037757.2 "Production method of hop extract with estrogenic and anti-proliferative activit...

Method used

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  • Method for preparing hop whitening extract
  • Method for preparing hop whitening extract
  • Method for preparing hop whitening extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Take 5 kg of hop raw material, crush it after removing impurities, pass through a 100-mesh sieve, add 50 L of 95% alcohol, heat to 60 ° C for extraction, filter, recover the filtrate, repeat three times, and the filtrate is concentrated under reduced pressure at 48 ° C to obtain total hops. Extract concentrated solution 1.92kg, reserve sample 181g, set aside. Add an appropriate amount of water to the concentrated solution to form a suspension, add 5L of petroleum ether for extraction, stir well, place it at room temperature for more than 6 hours, suck out the upper layer to obtain petroleum ether extract, and extract with petroleum ether three times to remove fat-soluble components; the lower layer of water Add 5L of ethyl acetate to the phase and extract continuously three times, combine the extracts, concentrate under reduced pressure at -0.09MPa and 48°C to recover the solvent, and obtain the crude extract of active components of hops, which is freeze-dried at -80°C t...

Embodiment 2

[0037]Take 1kg of hop raw material, remove impurities, crush, sieve, add 10L of 95% alcohol, heat to 55°C for extraction, filter, recover the filtrate, repeat three times, and concentrate the filtrate under reduced pressure at 50°C to obtain a crude extract for later use; Add an appropriate amount of water to the crude extract to form a suspension, then add 2L of petroleum ether to extract three times to remove fat-soluble components; add 2L of ethyl acetate to the lower aqueous phase for continuous extraction three times, combine the extracts, and store at -0.09MPa, 48°C Concentrate and recover the solvent under reduced pressure to obtain crude hop whitening extract extract, which is freeze-dried at -80°C to obtain hop whitening extract, a total of 320g; weigh 40g of crude extract, separate it with macroporous adsorption resin, collect 90% ethanol washing Dehydration, the flow rate is 20ml / min, the eluent is 3L, the eluent is concentrated under reduced pressure, and freeze-dri...

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Abstract

The invention provides a method for preparing a hop whitening extract, which relates to the field of cosmetic production. According to the invention, a simple and rapid method is used to extract an extract product with skin whitening activity from hops, and the experiments prove that the effective component can significantly reduce the melanin content and inhibit the transport of melanin particlesto keratinocytes. The preparation method comprises the following steps: pulverizing the hops after drying, adding 95% alcohol for extraction, extracting the obtained extract and adding petroleum ether for degreasing, extracting the active ingredient by adding ethyl acetate, decolouring the material by macroporous adsorption resin, and performing freeze drying to obtain a hop whitening effective component extract; adding 1,3-butanediol and deionized water, and filtering the material through a 0.22 [mu]m filter membrane to obtain the hop whitening extract.

Description

technical field [0001] The invention relates to the field of cosmetics manufacturing, in particular to a preparation method of hop whitening extract. Background technique [0002] With the improvement of people's living standards and aesthetic standards, white and clean skin is more and more respected by most women. And the enhancement of ultraviolet radiation intensity, the increase of work pressure and the lack of sleep will make the skin dark yellow and raw spots. In recent years, the development of skin whitening cosmetics has become increasingly active, and the research on the causes of skin melanin, whitening mechanism, evaluation of whitening effect, and selection of whitening agents in whitening cosmetics has continued to deepen. With the continuous understanding of the biological mechanism of melanin production and the safety problems of chemical whitening agents, it has become a hot spot in cosmetic research to find safe and efficient whitening active substances f...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/02A61Q19/00
CPCA61K8/97A61K2800/805A61Q19/00A61Q19/005A61Q19/02
Inventor 明磊国王清霞苟小会
Owner 陕西佰瑞衡健康科技有限公司
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