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Method for extracting CBD and CBDV at same time

A technology of extracting liquid and eluting liquid, which is applied in the field of chemistry, can solve problems such as waste of resources, and achieve the effects of low cost, reduced impact on the environment and operators, and simple and easy operation and method

Active Publication Date: 2019-04-05
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the above-mentioned patent documents involves the extraction of CBDV, resulting in a certain waste of resources. However, the prior art discloses that CBDV can be used in combination with standard antiepileptic drugs or other cannabinoid compounds such as CBD and THCV for the treatment of epilepsy. Therefore, using The high content of CBDV in flowers and leaves is also an important topic

Method used

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  • Method for extracting CBD and CBDV at same time
  • Method for extracting CBD and CBDV at same time
  • Method for extracting CBD and CBDV at same time

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] The process steps of simultaneously extracting CBDV and CBD are as follows:

[0086] 1) Grinding industrial hemp flower and leaf raw materials into 40-mesh coarse powder, baking at 105°C for 80 minutes, and the measured moisture content is 3.6%;

[0087] 2) soak the medicinal material obtained in step 1) with 6 times 95% ethanol at room temperature for 1 hour, extract by cold soaking method 3 times, and combine to obtain the extract;

[0088] 3) Concentrate the extract obtained in step 2) at 55°C to an alcohol content of 50%, add 95% ethanol to adjust the alcohol content to 60%, settle overnight, and obtain the supernatant;

[0089] 4) Pass the supernatant obtained in step 3) through the large-pore HPD 100 resin, wash 2BV with purified water, wash 4BV with 60% ethanol, start collecting CBDV from liquid chromatography, and stop when the concentration of CBDV is lower than 0.5g / L Collect the remaining part as waste liquid recovery solvent; then elute 5BV with 80% ethanol...

Embodiment 2

[0096] The process steps of simultaneously extracting CBDV and CBD are as follows:

[0097] 1) Grinding the raw material of industrial hemp mosaic leaves into 60-mesh coarse powder, baking at 150°C for 30 minutes, and the measured moisture content is 3.2%;

[0098] 2) Soak the medicinal material obtained in step 1) with 10 times 95% ethanol at room temperature for 1 hour, extract twice by cold soaking, and combine to obtain the extract;

[0099] 3) Concentrate the extract obtained in step 2) at 65°C to an alcohol content of 72%, filter with a plate and frame, and obtain a supernatant;

[0100] 4) Put the supernatant obtained in step 3) over HZ18 macroporous resin overnight, wash 3BV with purified water, wash 4BV with 60% ethanol, start collecting CBDV from the liquid phase inspection, and stop collecting when the concentration of CBDV is detected to be lower than 0.5g / L. Partially make waste liquid recovery solvent; then elute 5BV with 76% ethanol, start collecting from the l...

Embodiment 3

[0108] The process steps of simultaneously extracting CBDV and CBD are as follows:

[0109] 1) Grinding the raw material of industrial hemp mosaic leaves into 20-mesh coarse powder, baking at 120°C for 40 minutes, and the water content is 3.5%;

[0110] 2) Soak the medicinal material obtained in step 1) with 7 times 80% ethanol at 60°C for 1 hour, extract twice by cold soaking, and combine to obtain the extract;

[0111] 3) Concentrate the extract obtained in step 2) at 70°C to an alcohol content of 65%, filter with a plate and frame, and obtain a supernatant;

[0112] 4) Put the supernatant obtained in step 3) over D101 macroporous resin overnight, wash 2BV with purified water, wash 4BV with 65% ethanol, start collecting CBDV from the liquid phase inspection, and stop collecting when the CBDV concentration is lower than 0.5g / L. Partially make waste liquid recovery solvent; then elute 6BV with 82% ethanol, start collecting from the liquid phase inspection to CBD, and stop col...

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Abstract

The invention discloses a method for extracting CBD and CBDV at the same time. The method includes: smashing an extracted portion of hemp, and baking to obtain medicinal material powder; using a solvent to extract the medicinal material powder to obtain extraction liquid; concentrating the extraction liquid, and performing solid-liquid separation to obtain supernate; allowing the supernate to passan adsorption column, and eluting to obtain eluate 1 and eluate 2; respectively concentrating and purifying the eluate 1 and the eluate 2 to obtain CBDV and CBD. The method is low in cost and easy inoperation, and impact on environment and operation personnel and solvent residue in CBDV and CBD; purity and yield of target products in CBDV and CBD are high, CBD purity can be up to 99.7%, and one-time crystallization purity of CBDV can reach 98%; psychotoxic ingredient THC is removed and destroyed, so that CBDV and CBD are high in safety, and the method can realize industrial amplification.

Description

technical field [0001] The invention relates to the technical field of chemistry, in particular to a method for simultaneously extracting cannabidiol (CBD) and cannabidiol (CBDV). Background technique [0002] Cannabis (scientific name: Cannabis sativa L.) is a plant of the Cannabis family and the genus Cannabis, also known as hemp, hemp, hemp, mountain silk seedlings, and jute. It has important agricultural and medicinal values. Marijuana contains a toxic component tetrahydrocannabinol (THC), which can make people hallucinogenic and addictive, and can be used as a drug. It was banned for a long time. [0003] Due to the high economic and medicinal value of hemp, the raw material hemp exclusively for industrial use is referred to as "industrial hemp". Sucking as a drug can legally carry out large-scale planting and industrial development and utilization. [0004] At present, more than 500 substances have been isolated from cannabis plants, including at least 86 cannabinoid...

Claims

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Application Information

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IPC IPC(8): C07C37/68C07C39/23
CPCC07C37/004C07C39/23
Inventor 张可谭昕常坦然高伟博柳旭
Owner HANYI BIO TECH CO LTD
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