Application of total flavonoids of rosa roxburghii

A technology of roxburghines and total flavonoids, which is applied in the field of medicine, can solve problems such as the lack of information about the therapeutic effect of roxburghines, reduce the degree of vacuolar lesions and inflammatory infiltration, reduce liver volume enlargement and weight gain, Effect of TG content reduction

Inactive Publication Date: 2019-04-16
阎永平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is no relevant information on the therapeutic effect of Rosa roxburghii flavonoids on alcoholic liver disease

Method used

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  • Application of total flavonoids of rosa roxburghii
  • Application of total flavonoids of rosa roxburghii
  • Application of total flavonoids of rosa roxburghii

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Various Rosa roxburghii extracts are used for the prevention and treatment of alcoholic liver disease caused by the NIAAA model

[0051] 1. Instruments and materials

[0052] Main instruments: electronic balance (Shanghai METTLER TOLEDO); Buchi rotary evaporator (Switzerland Buchi); electric heating mantle (Tianjin Tioste Instrument Co., Ltd.); traditional Chinese medicine pulverizer (Shanghai Dianjiu Traditional Chinese Medicine Machinery Manufacturing Co., Ltd.); Full-wavelength microplate reader (Thermo Company, USA); centrifuge (Eppendorf Company, Germany); low-speed desktop centrifuge (Keda Zhongjia); DZF-6020 vacuum drying oven (Shanghai Jinghong).

[0053] Drugs and reagents: liquid feed (Lieber-DeCarli diet ad libitum) and liquid alcohol feed (Nantong Trophy Feed Technology Co., Ltd.); ethanol (Burdick&Jackson); AB-8 macroporous adsorption resin (Beijing Huanyu Kechuang Biotechnology Development Co., Ltd. Co., Ltd.); Dried roxburghii (Guangrentang Med...

Embodiment 2

[0083] Example 2: Preparation of tablets and capsules comprising 11-99% total flavonoids of Rosa roxburghii:

[0084] Get the dry powder of the total flavonoids of Rosa roxburghii, pass through a 60-100 mesh sieve for later use. (1) Add one or several kinds of excipients commonly used in tablets; compress into tablets by a tablet machine. Each tablet contains 110-440 mg of total flavonoids of Rosa roxburghii, and the weight of the tablet can be adjusted according to the drug loading. (2) Add one or several kinds of auxiliary materials commonly used in capsules, granulate, granulate, and pack into capsules. Each capsule contains 110-440 mg of total flavonoids of Rosa roxburghii, and the weight of the capsule can be adjusted according to the drug loading. See Table 5. Suggested dosage: 6 capsules per day, 2 capsules per meal, 110-220mg total flavonoids of Rosa roxburghii per capsule; daily intake is 660-1320mg. Or take 3 pills per day, 1 pill / meal, 220-440mg total flavonoids...

Embodiment 3

[0095] Embodiment 3: preparation comprises 3.3-99% granules and suspensions of total flavonoids of Rosa roxburghii:

[0096] Taking 10g / bag as an example, the specific dosage form specification (weight / bag) can be adjusted according to the drug loading. Get the dry powder of the total flavonoids of Rosa roxburghii, pass through a 60-100 mesh sieve for later use. Take 330-1320g of the above-mentioned dry powder, arbitrarily proportioning 8680-9670g of auxiliary materials; make the total weight 10000g. Add a small amount of solvent and mix well to make granules, dry, pack one bag per 10g; 1000 bags in total. The excipients include, but are not limited to: sweeteners, powdered sugar, dextrin, β-cyclodextrin, and effervescent disintegrants. The prepared Rosa roxburghii total flavonoid granule contains 3.3-13.2% of Rosa roxburghii total flavonoids in each bag; the recommended dosage is: take 1-2 bags per day, and the daily intake is 660-1320 mg. See Table 6.

[0097] Table 6-Ta...

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Abstract

The invention discloses an application of total flavonoids of rosa roxburghii in preparation of drugs, health-care products and health-care food for preventing and treating alcoholic liver disease. Provided are drugs and health-care products for preventing and treating alcoholic liver disease, wherein the drugs and health-care products comprise 3-99% of the total flavonoids extract of rosa roxburghii, and the total flavonoids extract of rosa roxburghii are used as an active ingredient. The invention also provides health-care drinks suitable for patients with alcoholic liver disease, wherein the health-care drinks comprise 0.08-1% of the total flavonoids of rosa roxburghii. Through implementation of a most recognized model of alcoholic liver disease in mice, the total flavonoids of rosa roxburghii are found out to obviously alleviate the liver pathological changes induced by alcohol; liver enlargement, weight gain, fat accumulation and inflammatory infiltration degree are significantlyimproved; biochemical and pathological indicators are decreased greatly. Therefore, the total flavonoids of rosa roxburghii can prevent and treat alcoholic liver disease, can be used as drugs separately or in combination and are used for developing corresponding drugs, health-care products or health-care food.

Description

technical field [0001] The invention belongs to the field of medicine. It relates to roxburghii extract and its application. More specifically, it relates to the total flavonoids of Rosa roxburghii and its application in the preparation of drugs and / or health products for the prevention and / or treatment of alcoholic liver disease. The total flavonoids of Rosa roxburghii can be obtained by different processes. Background technique [0002] Alcoholic liver disease (ALD), including alcoholic fatty liver (AFL), alcoholic hepatitis (AH), and alcoholic cirrhosis (AC); is caused by long-term heavy drinking liver damage; different disease processes often co-exist. At present, excessive alcohol intake has become the second leading cause of liver injury after viral hepatitis in my country. Clinical data confirm that 80% to 90% of liver cirrhosis is caused by excessive drinking. Epidemiological data in 2000 showed that the population suffering from alcoholic liver disease accounte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61P1/16C12G3/055C12G1/00C12C12/00
CPCA23V2002/00A61K36/738A23L33/105C12C12/00C12G1/00C12G3/04A23V2200/32A23V2250/2116A23V2250/5118A23V2250/51082A23V2250/51084A23V2250/51088A23V2250/5112A23V2250/5114A23V2250/612
Inventor 胡冰芳
Owner 阎永平
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