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Double-layer microencapsulation prebiotic and probiotic composition and preparation method thereof

A technology of prebiotics and probiotics, applied in the field of biomedicine, can solve the problems affecting the embedding effect of probiotics and the biological activity of probiotics, so as to improve the body's immunity, increase the encapsulation yield and efficiency, and embedding efficiency high effect

Pending Publication Date: 2019-04-26
山东探克生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microcapsules prepared by this invention can achieve the effect of localized and sustained release; however, acidic and alkaline substances are used in the preparation method, which will contact with probiotics, which will affect the biological activity of probiotics, thereby affecting the embedding of probiotics Effect

Method used

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  • Double-layer microencapsulation prebiotic and probiotic composition and preparation method thereof
  • Double-layer microencapsulation prebiotic and probiotic composition and preparation method thereof
  • Double-layer microencapsulation prebiotic and probiotic composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A double-layer microencapsulated prebiotic and probiotic composition, comprising a wall material and a core material; the mass ratio of the wall material and the core material is 2:1;

[0051] The wall material includes: an outer wall material and an inner wall material; the mass ratio of the inner wall material to the outer wall material is 1:1;

[0052] The outer wall material is made of the following raw materials in parts by mass: 24 parts of sodium alginate, 5 parts of glucose, 10 parts of β-cyclodextrin, and 10 parts of maltodextrin;

[0053] The inner wall material is made of the following raw materials by mass: 15 parts of poly-L-arginine, 25 parts of chitosan, 1 part of ginseng polysaccharide, 1 part of Pleurotus eryngii polysaccharide, 3 parts of inulin, 2 parts of fructooligosaccharide part, 2 parts of isomaltooligosaccharide;

[0054] The core material is made of the following raw materials in parts by mass: 35 parts of probiotics, 14 parts of skim milk pow...

Embodiment 2

[0065] A double-layer microencapsulated prebiotic and probiotic composition, comprising a wall material and a core material; the mass ratio of the wall material and the core material is 4:1;

[0066] The wall material includes: an outer wall material and an inner wall material; the mass ratio of the inner wall material to the outer wall material is 3:1;

[0067] The outer wall material is made of the following raw materials in parts by mass: 15 parts of sodium alginate, 10 parts of glucose, 5 parts of β-cyclodextrin, and 5 parts of maltodextrin;

[0068] The inner wall material is made of the following raw materials by mass: 45 parts of poly-L-arginine, 40 parts of chitosan, 3 parts of ginseng polysaccharide, 3 parts of Pleurotus eryngii polysaccharide, 8 parts of inulin, 3 parts of fructooligosaccharide part, 3 parts of isomaltooligosaccharide;

[0069] The core material is made of the following raw materials in parts by mass: 28 parts of probiotics, 7 parts of skim milk pow...

Embodiment 3

[0080] A double-layer microencapsulated prebiotic and probiotic composition, comprising a wall material and a core material; the mass ratio of the wall material and the core material is 4:1;

[0081] The wall material includes: an outer wall material and an inner wall material; the mass ratio of the inner wall material to the outer wall material is 6:1;

[0082] The outer wall material is made of the following raw materials in parts by mass: 30 parts of sodium alginate, 15 parts of glucose, 15 parts of β-cyclodextrin, and 15 parts of maltodextrin;

[0083] The inner wall material comprises the following raw materials by mass: 30 parts of poly-L-arginine, 30 parts of chitosan, 5 parts of ginseng polysaccharide, 5 parts of Pleurotus eryngii polysaccharide, 10 parts of inulin, 5 parts of fructooligosaccharide part, 5 parts of isomaltooligosaccharide;

[0084] The core material comprises the following raw materials in parts by mass: 49 parts of probiotics, 10.9 parts of skim milk...

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Abstract

The invention provides a double-layer microencapsulation prebiotic and probiotic composition and a preparation method thereof. A microencapsulation protection technology is used; natural polymer sodium alginate, glucose and prebiotics are used as outer wall materials; poly-L-arginine and prebiotics are used as inner wall materials; probiotics and dried skim milk are used as core materials. The specific double-layer microencapsulation structure provides dual protection for unstable probiotics; the influence of external environment and adverse factors (such as light, temperature, humidity, pH and bile) is avoided; the reduction of probiotic activity in the use and storage processes is effectively prevented; the stability, the activity and the effective fix planting rate of the composition are maintained to the greatest degree; the embedding efficiency is high; the embedding effect is good. The double-layer microencapsulation composition has the advantages that the directional controlledrelease effect can be effectively realized; the intestinal flora balance can be effectively reduced; the body immunity is improved.

Description

technical field [0001] The invention relates to a double-layer microencapsulated prebiotic, a probiotic composition and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] A prebiotic is a dietary supplement, a type of dietary fiber, that can have beneficial effects on the human body by selectively stimulating the growth and activity of bacteria. These complex carbohydrates are not digested in the small intestine and preferentially promote the growth of Bifidobacteria and Lactobacillus plantarum in the colon. For the human body, the utilization of prebiotics is the absorption of intestinal flora. [0003] The probiotics in the intestinal flora are healthy bacteria and microorganisms that are beneficial to the human body. They can directly act on the intestinal tract, regulate the intestinal flora by inhibiting the growth of harmful bacteria, improve intestinal function, promote the absorption of nutrients, and enhance...

Claims

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Application Information

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IPC IPC(8): A23L33/135A23C9/00A23P10/30
CPCA23C9/00A23L33/135A23P10/30A23V2002/00A23V2200/3204A23V2200/324
Inventor 张义杨燕朱成龙苏真真高丽鹤甘玉迪杨淑名刘建
Owner 山东探克生物科技股份有限公司
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