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Method for preparing bisbenzylisoquinoline compounds

A technology of bisbenzylisoquinoline and compounds, applied in the field of medicine, can solve the problems of refractory treatment and many "three wastes"

Active Publication Date: 2019-04-26
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are many "three wastes" and difficulties in the preparation of these compounds. Therefore, it is very necessary to develop a green, convenient, fast and high-yield drug synthesis method

Method used

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  • Method for preparing bisbenzylisoquinoline compounds
  • Method for preparing bisbenzylisoquinoline compounds
  • Method for preparing bisbenzylisoquinoline compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: R in formula (I') 2 is o-fluorobenzyl, Yn is Cl - 2 ,

[0045] Solvent method: Weigh 6.23g of tetrandrine and 0.20g of potassium hydride, dissolve it in 200mL of methanol in a 500mL three-necked flask, add 3.00g of o-fluorobenzyl chloride, stir and heat to boiling, and keep stirring for 8h, TLC detection of tetrandrine After the whole reaction, cool down to room temperature, add 80 mL of water after distilling off methanol, extract 3 times with dichloromethane (100 mL×3), trace the separation and purification process of the reaction and product by TLC, recover dichloromethane from the extract, and store the solid at 60°C After drying for 4 hours, 7.30 g of a light yellow powder was obtained, with a yield of 80%. The melting point of the target product: 207.7-209.5°C, 13 C NMR (CDCl 3 ,100MHz)δ160.77,157.87,152.75,150.35,148.34,147.80,147.38,146.09,142.95,137.64,137.51,137.33,133.77,131.71,131.41,129.71,129.65,129.54,128.26,128.06,127.66,127.54,126.90,1...

Embodiment 2

[0050] Example 2: R in formula (I') 2 is p-fluorobenzyl, Yn is Cl - 2 ,

[0051] Solvent method: Weigh 18.70g of tetrandrine and 0.20g of sodium ethoxide, dissolve it in 360mL of absolute ethanol in a 500mL three-neck flask, then add 9.00g of p-fluorobenzyl chloride, stir and heat to boiling, and keep stirring for 36h, TLC detection Tetrandrine was completely reacted, distilled off absolute ethanol, cooled to room temperature, added 100mL of water, extracted 3 times with chloroform (150mL×3), followed the separation and purification process of reaction and product by TLC, recovered chloroform from the extract, solid The product was dried at 60° C. for 4 hours to obtain 16.55 g of a light yellow powder product with a yield of 60.6%. The melting point of the target product: 208.5-209.9°C, 13 C NMR (CDCl 3 ,100MHz)δ163.55,161.11,153.75,151.39,149.43,148.78,148.52,147.13,143.95,137.41,137.29,136.98,135.12,133.61,133.54,132.65,132.55,132.43,130.09,130.01,128.65,128.43,128.26...

Embodiment 3

[0056] Example 3: R in formula (I') 2 is (2,5-difluoro)benzyl, Yn is Cl - 2 ,

[0057] Solvent method: Weigh 6.23g of tetrandrine and 0.50g of potassium carbonate, dissolve it in 100mL of propanol in a 500mL three-necked flask, then add 3.60g of 2,5-difluorobenzyl chloride, heat and stir until boiling, and keep stirring for 24h , TLC detects the entire reaction of tetrandrine, distills off the solvent under reduced pressure, cools down to room temperature, adds 100 mL of water, extracts with acetone for 3 times (150 mL×3), traces the separation and purification process of the reaction and the product by TLC, and uses anhydrous Na 2 SO 4 After drying for 8 hours, acetone was recovered, and the solid was dried at 60° C. for 4 hours to obtain 8.22 g of a light yellow powder product with a yield of 86%. The melting point of the target product: 209.2-210.7°C, TOF-HRMS: M / e (947.8780), molecular formula: C 52 h 52 o 6 N 2 f 4 Cl 2 .

[0058] Ionic liquid method: Weigh 6...

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Abstract

The invention provides a preparation method of bisbenzylisoquinoline compounds. The method comprises the following steps: taking a formula (A) and RX as reactants and carrying out a reaction in a reactor in the presence of ionic liquid or assistants; detecting the reaction progress by chromatography; after the reaction ends, separating and purifying or further adding acid and neutralizing to neutral; then separating and purifying to obtain the bisbenzylisoquinoline compound (The formula is shown in the specification). The method has the advantages of simplicity, environmental protection, highefficiency, as well as high yield which is 90 percent or above, is up to 98 percent or above and is far higher than the yield of a traditional solvent method (20 to 80 percent).

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for preparing bisbenzylisoquinoline compounds. Background technique [0002] Bisbenzylisoquinoline compounds (Bisbenzylisoquinoline compounds) have anti-cancer, antibacterial, anti-inflammatory, antihypertensive, muscle relaxation, and immune function regulation effects, among which the more important natural bisbenzylisoquinoline compounds include Tetanus Tetrandrine, tetrandrine, berbamine, stephenine, chrysanthemum, curine, etc., such as tetrandrine, also known as tetrandrine or tetrandrine, is mainly used clinically for rheumatic pain and arthralgia , Neuralgia, also used for silicosis; it is a very important compound. However, there are many "three wastes" and difficulties in the preparation of these compounds. Therefore, it is very necessary to develop a green, convenient, fast and high-yield drug synthesis method. Contents of the invention [0003] The object of the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/18
CPCC07D491/18
Inventor 刘玉法张彦春吕绪涛李天雯丁启文崔启铭吴泽晓
Owner SHANDONG NORMAL UNIV
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