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A kind of preparation method of collagen fiber

A technology of collagen fibers and collagen, which is applied in the direction of fiber chemical characteristics, single-component protein rayon, textiles and papermaking, etc., can solve the problems of reducing the practical application and easily destroying collagen activity, and achieves non-destructive and independent structure The effect of high safety and high biosafety

Active Publication Date: 2021-05-04
无锡贝迪生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the complex pre- and post-processing of collagen in the spinning process in the prior art, as well as the problem of easily destroying the activity of collagen and reducing its practical application, the present invention provides a method for preparing collagen fibers

Method used

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  • A kind of preparation method of collagen fiber

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 5g collagen is dissolved in 200g chloride N-butyl-N-methyldiethanolamine ionic liquid aqueous solution (the concentration of ionic liquid is 0.04wt%), and the pH of adjustment solution is 3, injects after centrifugal defoaming of collagen solution In the storage tank of the spinning machine, under the pressure of 0.1MPa, the spinning solution is sprayed from the spinneret to the first coagulation bath containing 20L ethanol (concentration is 90%) by the metering pump, and the spinneret The pore size is 70 μm, and the speed at which the collagen solution is ejected from the spinneret is 10m / min, and the collagen solution is immediately dehydrated and solidified into a fibrous shape, and the drafting speed in the first coagulation tank is 20m / min; The collagen fiber that a coagulation bath comes out enters in the 2nd coagulation bath (ethanol 20L, concentration is 99.5%) by drafting, further dehydration under room temperature, the collagen fiber that comes out from the 2nd...

Embodiment 2

[0042]10g of collagen is dissolved in 200g of N-hexyl-N-methyldiethanolamine chloride ionic liquid aqueous solution (concentration is 0.08wt%), and the pH of the control solution is 3, and the collagen solution is centrifugally defoamed and injected into the spinning In the storage tank of the machine, under the pressure of 0.1MPa, the spinning solution is sprayed from the spinneret to the first coagulation tank containing 20L ethanol (concentration is 90%) through the metering pump, and the aperture of the spinneret is 100 μm, the speed at which the collagen solution is ejected from the spinneret is 15m / min, and the collagen solution is immediately dehydrated and solidified into a fibrous shape, and the drafting speed in the first coagulation tank is 25m / min. The collagen fibers coming out of the first coagulation bath are drawn into the second coagulation bath (20 L of ethanol, the concentration is 99.5%), and further dehydrated at room temperature. Collagen fibers coming ou...

Embodiment 3

[0044] 16g of collagen is dissolved in 200g of N-butyl-N-methyldiethanolamine chloride ionic liquid (concentration is 0.4wt%), the pH of the control solution is 4, and the collagen solution is centrifugally defoamed and injected into the spinning In the storage tank of the machine, under the pressure of 0.1MPa, the spinning solution is sprayed from the spinneret to the first coagulation tank containing 20L ethanol (concentration is 90%) through the metering pump, and the aperture of the spinneret is 200 μm, the speed at which the collagen solution is ejected from the spinneret is 30m / min, and the collagen solution is immediately dehydrated and solidified into a fibrous shape, and the drafting speed in the first coagulation tank is 50m / min. The collagen fibers coming out of the first coagulation bath are drawn into the second coagulation bath (20 L of ethanol, the concentration is 99.5%), and further dehydrated at room temperature. Collagen fibers coming out of the second coagu...

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Abstract

The invention discloses a method for preparing collagen fibers, which belongs to the field of tissue engineering and regenerative medicine. In the present invention, animal collagen is used as raw material, and collagen solution is prepared by dissolving ionic liquid, and then the collagen solution is coagulated and assembled into collagen fibers with a triple helical structure through a wet spinning device in an organic coagulation bath. After being spun by a spinning device, it can be rolled up and unbroken, and what is obtained is a continuous, non-bonded collagen thread. The collagen fibers prepared by the method of the present invention are not subjected to any chemical cross-linking treatment, and are obtained as type I collagen fibers. Collagen itself has good nutrition and repair functions. The cells can be effectively repaired, so that the tissue structure at the wound can be restored to the preoperative state as much as possible. The product can be used for superficial suture or plastic surgery to smooth the wound surface without leaving scars.

Description

technical field [0001] The invention relates to a preparation method of collagen fibers, belonging to the fields of tissue engineering and regenerative medicine. Background technique [0002] Collagen has good biological properties and functions, mainly in: (1) Low antigenicity: Compared with other immunogenic proteins, collagen has very low immunogenicity; (2) Biodegradability: Under the action of protease, the peptide chain of collagen is hydrolyzed and gradually interrupted, and then the helical structure is destroyed, causing the collagen to be completely hydrolyzed by protease, which is the biodegradability of collagen; (3) good biocompatibility : Collagen has a good interaction with host cells and tissues, showing the coordination of mutual influence. Materials made from collagen can be directly applied to animal and human tissues as medical substrates to maintain the shape of the tissues. Collagen can be processed into various medical appliances that are convenient ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F4/00
CPCD01F4/00
Inventor 刘石林任伟业陈敬华程咏梅陆金婷
Owner 无锡贝迪生物工程股份有限公司