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Redox active metal/metal oxide composites for antimicrobial applications

A metal complex, anti-microbial technology, used in chemicals for biological control, applications, paints containing biocides, etc., can solve the problems of low ROS concentration and low efficiency, and achieve high redox activity, high microbial The effect of killing activity

Inactive Publication Date: 2019-04-26
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

ROS concentrations may be relatively low and less efficient

Method used

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  • Redox active metal/metal oxide composites for antimicrobial applications
  • Redox active metal/metal oxide composites for antimicrobial applications
  • Redox active metal/metal oxide composites for antimicrobial applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1: ZnO-metal foil with antimicrobial properties

[0074] ZnO coatings on Zn, Al and Fe substrates were prepared. 0.1 g of ZnO powder with a particle size of 200–500 nm was added to 1 mL of ethanol and dispersed by ultrasonic waves for 5 minutes. 100 μL of the solution was dispersed on the surface of Zn, Al and Fe substrates with dimensions 2×2 cm. After evaporation of the ethanol, an additional 100 μL of the solution was applied. After evaporating ethanol, a uniform ZnO coating was formed on the surface.

[0075]Submicron ZnO powders deposited on different substrates (Zn, Al, and steel) form ZnO coatings ( figure 1 ). The antimicrobial activity of coated metals was evaluated using the JIS Z2801 / ISO 22196 method, which is recognized as the industry standard for evaluating antimicrobial surfaces.

[0076] Such as figure 2 As shown, all bacterial cells of E. coli on ZnO-coated ZnO / Zn, ZnO / Al and ZnO / Fe surfaces were killed (log reduction greater than 8) aft...

Embodiment 2

[0079] Example 2: ZnO-Zn particles with antimicrobial properties

[0080] ZnO / Zn core / shell particles were prepared from commercially available zinc powder (Sigma) using two different methods. The as-received Zn powder is spherical and has a smooth surface ( Figure 4 A).

[0081] For the growth of ZnO nanoneedles, in KOH and Zn(NO 3 ) 2 treatment of Zn powder in the solution. 5ml of 0.5M Zn(NO 3 ) 2 The aqueous solution and 5 ml of 4M aqueous KOH were charged to a reaction tube. 1 g of Zn particles was added. The mixture was kept at room temperature for 2 hours with gentle stirring. After that, the powder was washed 3 times with water and 3 times with ethanol, dried in vacuum and stored for future use. When using KOH / Zn(NO 3 ) 2 When the Zn powder was solution-treated for 2 hours, ZnO columns grew on the surface of the Zn particles ( Figure 4 B).

[0082] ZnO-Zn particles were also prepared by high temperature growth reaction. to 0.1M ZnSO 4 Add 30% NH to the ...

Embodiment 3

[0088] Example 3: Fe with antimicrobial properties 2 o 3 -Zn foil

[0089] Add 0.1g Fe to 1mL ethanol 2 o 3 powder and disperse by ultrasonication for 5 minutes. 100 μL of the solution was spread on the surface of the Zn substrate (2×2 cm). After evaporation of the ethanol, an additional 100 μL of the solution was applied. After evaporating ethanol, a uniform Fe was formed on the surface 2 o 3 coating.

[0090] In addition to ZnO / metal composites, Fe 2 o 3 / Zn complexes also exhibit high bactericidal activity. Such as Figure 6 As shown, the preparation of micron-sized Fe 2 o 3 particles and coated on the Zn foil surface. Antibacterial activity was then evaluated by using the JIS method.

[0091] Such as Figure 6 As further shown in Escherichia coli, all bacterial cells in the Fe 2 o 3 / Zn are killed with a log reduction >8, while Fe alone 2 o 3 The granules did not exhibit any bactericidal properties.

[0092] In summary, as shown in the examples, includ...

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Abstract

The invention relates to a method of preparing a metal oxide / metal composite, comprising depositing a metal oxide from a dispersion in a liquid on a metal surface; or depositing a metal oxide in the presence of a metal from a dispersion in a liquid on a substrate; or depositing a metal oxide from a metal salt solution on a metal substrate. The metal oxide / metal composites obtained by the process show synergistic antimicrobial activity due to release of high concentrations of redox active species (ROS) at the metal oxide / metal heterojunction. The invention also relates to use of the metal oxide / metal composite as an antimicrobial coating.

Description

technical field [0001] The present invention generally relates to a process for the preparation of antimicrobial redox active metal oxide / metal composites having exceptional microbicidal activity due to the high redox activity generating higher reactive oxygen species than the individual components Substance (reactive oxygen species, ROS) concentration. The invention also relates to such materials and their use in antimicrobial applications. Background technique [0002] Microbial infection is one of the most serious problems in many commercial applications such as medical devices, hospital surfaces, textiles, packaging, appliances, filters and public surfaces. Creating clean antimicrobial surfaces with long-term stability and activity has enormous applications, including nearly all aspects of our daily lives, from medical devices to architectural surfaces. Organic molecular antimicrobials such as triclosan and biguanides are currently standard ingredients in consumer care...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/02C09D5/14A01N59/00A01P1/00
CPCC09D1/00C09D5/14C09D7/61C09D7/66A61L2/232C23C22/60C23C22/62C23C22/66C23C22/68A01N59/16A01N59/06A01N25/08A01N25/26
Inventor 张玉根衣光舜
Owner AGENCY FOR SCI TECH & RES
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