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Anti-myeloma drug carrying microsphere with targeting and responding sustained release characteristics and preparation method thereof

A technology of drug-loaded microspheres and myeloma, which is applied in the field of biomedicine, can solve the problems of human body toxicity and side effects, and achieve the effects of no biological toxicity, targeted effect, and strong drug loading capacity

Active Publication Date: 2019-04-30
EAST CHINA JIAOTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the research and development of drug carrier polymer materials has received a lot of attention, because it enters the body with drugs, some stay in the body temporarily, and some are degraded and absorbed in the body, so it may cause toxic and side effects to the human body

Method used

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  • Anti-myeloma drug carrying microsphere with targeting and responding sustained release characteristics and preparation method thereof
  • Anti-myeloma drug carrying microsphere with targeting and responding sustained release characteristics and preparation method thereof
  • Anti-myeloma drug carrying microsphere with targeting and responding sustained release characteristics and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: At room temperature, 30ml of a 2.5% calcium chloride aqueous solution was poured into a three-necked flask containing 150ml of MMT aqueous suspension at a constant speed, mechanically stirred for 4 hours, and thoroughly mixed. Slowly add 30ml mass concentration of 5%Na 2 CO 3 Aqueous solution, while controlling the pH at 7, after the dropwise addition of the solution, continue to stir for 2 hours, let stand for aging for 24 hours, filter and wash with suction, dry in an oven at 80°C for 2 hours, and roast in a tube furnace for 1 hour. After grinding the roasted product, configure it into an aqueous suspension with a mass concentration of 5%, add 10 ml of an aqueous sodium dihydrogen phosphate solution with a concentration of 0.1 mol / L dropwise into the suspension, stir it mechanically for 0.5 h, and transfer the mixed solution to In a polytetrafluoroethylene-lined hydrothermal reaction kettle, react at 120° C. for 1 hour, pour out the product in the hydrothe...

Embodiment 2

[0025] Example 2: At room temperature, 30 ml of a 1% calcium chloride aqueous solution was poured into a three-necked flask containing 150 ml of MMT aqueous suspension at a constant speed, mechanically stirred for 4 hours, and thoroughly mixed. Slowly add 30ml mass concentration of 2%Na 2 CO 3 Aqueous solution, while controlling the pH at 8, after adding the solution dropwise, continue to stir for 2 hours, let stand for aging for 24 hours, filter and wash with suction, dry in an oven at 80°C for 2 hours, and roast in a tube furnace for 1 hour. After grinding the roasted product, configure it into an aqueous suspension with a mass concentration of 5%, add 10 ml of a disodium hydrogen phosphate aqueous solution with a concentration of 0.1 mol / L dropwise into the suspension, stir it mechanically for 0.5 h, and transfer the mixed solution to In a polytetrafluoroethylene-lined hydrothermal reaction kettle, react at 120° C. for 1 hour, pour out the product in the hydrothermal react...

Embodiment 3

[0026] Example 3: At room temperature, 30 ml of a 5% calcium chloride aqueous solution was poured into a three-necked flask containing 150 ml of MMT water suspension at a constant speed, mechanically stirred for 4 hours, and thoroughly mixed. Slowly add 30ml mass concentration of 8%Na 2 CO 3Aqueous solution, while controlling the pH at 7, after the dropwise addition of the solution, continue to stir for 2 hours, let stand for aging for 24 hours, filter and wash with suction, dry in an oven at 80°C for 2 hours, and roast in a tube furnace for 1 hour. After grinding the roasted product, configure it into an aqueous suspension with a mass concentration of 5%, add 10 ml of a disodium hydrogen phosphate aqueous solution with a concentration of 0.1 mol / L dropwise into the suspension, stir it mechanically for 0.5 h, and transfer the mixed solution to In a polytetrafluoroethylene-lined hydrothermal reaction kettle, react at 120° C. for 1 hour, pour out the product in the hydrothermal...

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Abstract

The invention discloses an anti-myeloma drug carrying microsphere with targeting and responding sustained release characteristics and a preparation method thereof. According to the preparation method,montmorillonite with a layered structure is taken as the support carrier; through cation exchange, spherical nano calcium carbonate with a controllable size is synthesized between montmorillonite layers to prepare a MMT-nano CaCO3 precursor template; through anion exchange, spherical nano CaCO3 is converted into nano HAp to obtain a HAp-MMT drug carrier; at the same time, through the electrostatic adsorption effect, chitosan is connected to the MMT surface and is taken as a connector; the amino groups of the chitosan are bonded to carboxyl groups through covalent bonds; and polypeptide A54, which can target anti-myeloma cells, is introduced into the microsphere to prepare the drug carrying microsphere having functions of active targeting and pH responding sustained releasing. The technology is simple, the adopted chemical reagents are common, the prepared drug carrying microsphere has a pH responding characteristic and a strong drug carrying performance; by introducing the targeting molecules actively, the microsphere has an active tumor cell targeting performance; and the carrier can promote bone repairing during the myeloma treatment process.

Description

technical field [0001] The invention relates to an anti-myeloma drug-loaded microsphere with targeting and response slow-release characteristics and a preparation method, belonging to the technical field of biomedicine. Background technique [0002] Multiple myeloma (multiple myeloma, MM) is a malignant proliferative disease originating from plasma cells. The monoclonal immunoglobulin produced and secreted by myeloma cells, and the cytokines secreted by plasma cells and bone marrow stromal cells eventually lead to Multiple myeloma clinical symptoms including anemia, renal insufficiency, hypercalcemia, and bone pain (CRAB). MM is the second largest tumor of the blood system. The annual incidence of MM in North America, Europe and Asia is about 3.5-4.5 / 100,000, 2.5-3.5 / 100,000, and 0.5-2.0 / 100,000, respectively. Dr. Akana Swami of the United States recently published a research paper in the Proceedings of the National Academy of Sciences of the United States, saying that the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/64A61K47/60A61K47/54A61P35/00
CPCA61K47/549A61K47/60A61K47/64A61K47/6923A61P35/00
Inventor 王少会温博谈逸茗王少民谌芸谢小丽
Owner EAST CHINA JIAOTONG UNIVERSITY