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Injectable and degradable artificial bone material and preparation method thereof

A technology of artificial bone and main material, applied in the field of biomedical materials, can solve the problems of poor pore structure, incomplete degradation, low biological activity, etc., to reduce the risk of infection, adjust the porosity, and improve the effect of biological activity.

Active Publication Date: 2019-05-03
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some of these materials contain non-degradable components (such as: hydroxyapatite, reinforcing fibers), resulting in incomplete degradation after injection molding, poor pore structure and low biological activity.

Method used

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  • Injectable and degradable artificial bone material and preparation method thereof
  • Injectable and degradable artificial bone material and preparation method thereof
  • Injectable and degradable artificial bone material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The injectable self-curing degradable bone filling material of this embodiment consists of two parts, a solid phase and a liquid phase, and its preparation method is as follows:

[0034] First take by weighing 0.9g of β-TCP (Mg / (Ca+Mg)=10at.%) material ( figure 1 ) and 2.1g of CSH materials with a particle size of 5-60μm ( figure 2 ), and the two materials are fully mixed to obtain a solid phase material. Add 1.2ml of PVA aqueous solution (concentration: 5wt%, liquid phase) to the above-mentioned solid phase powder, and mix uniformly for 30 seconds to prepare an injectable and degradable artificial bone material (30%β-TCP+70%CSH).

[0035] The curing time is measured with reference to the ASTM C191-18a standard. The solid-liquid mixed paste material is injected into a φ6*10mm stainless steel mold through a syringe, and then placed in a mold box (temperature: 37°C, humidity: 95%), and samples are taken out regularly Carry out the Vicat meter measurement until the Vica...

Embodiment 2

[0038] The injectable self-curing degradable bone filling material of this embodiment consists of two parts, a solid phase and a liquid phase, and its preparation method is as follows:

[0039] First weigh 0.87g of β-TCP material (Mg / (Ca+Mg)=10at.%) with an average particle size of 10-40μm after soft agglomeration, 2.1g of CSH material with an average particle size of 5-60μm and 0.03g metal Magnesium powder (particle size less than 75 μm), the three are fully mixed to obtain a solid phase material. Add 1.2ml of PVA aqueous solution (concentration 5wt%, liquid phase) to the above-mentioned solid phase powder, and make an injectable and degradable artificial bone material after uniform mixing for 30 seconds

[0040] (29% β-TCP + 70% CSH + 1% Mg).

[0041] With reference to the ASTM C191-18a standard, the final setting time of the sample measured is 17.7 ± 1.2min ( image 3 ). The injectable artificial bone material was prepared into φ6*10mm samples (5 parallel samples), and t...

Embodiment 3

[0043] The injectable self-curing degradable bone filling material of this embodiment consists of two parts, a solid phase and a liquid phase, and its preparation method is as follows:

[0044] First weigh 0.75g of β-TCP material (Mg / (Ca+Mg)=10at.%) with an average particle size of 10-40μm after soft agglomeration, 2.1g of CSH material with an average particle size of 5-60μm and 0.15g metal Magnesium powder (less than 75 μm), the three are fully mixed to obtain a solid phase material. Add 1.2ml of PVA aqueous solution (concentration 5wt%, liquid phase) in above-mentioned solid phase powder, make injectable, biodegradable artificial bone material (25%β-TCP+70%CSH+5%Mg ).

[0045] With reference to the ASTM C191-18a standard, the final setting time of the sample measured is 27.7 ± 1.2min ( image 3 ), the injectable artificial bone material was prepared into φ6*10mm samples (5 parallel samples), and the compressive strength of the samples measured after complete curing was 2.2...

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Abstract

The invention relates to the technical field of biomedical materials, in particular to an injectable and degradable artificial bone material and a preparation method thereof. The material consists ofa solid phase and a liquid phase. The solid phase host material is a nano beta phase tricalcium phosphate and calcium sulfate hemihydrate powder material, and the solid phase auxiliary functional material is metal magnesium, magnesium strontium alloy or a metal zinc powder material. The liquid phase is a 5% by weight polyvinyl alcohol aqueous solution or normal saline. The solid phase and the liquid phase are uniformly mixed for use, the curing time range is 5-60min, and the curing strength range is 2-10 MPa, so that the artificial bone material is formed. Compared with existing artificial bone materials, on the one hand, a nano beta-TCP material in the bone material improves the biological activity of the artificial bone material after implantation; and on the other hand, the metal or alloy powder can rapidly degrade in the body, and forms a pore canal structure inside the artificial bone material so as to realize a self pore forming process, to facilitate the transportation of nutrients and to promote the growth of cells and capillaries.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an injectable and degradable artificial bone material and a preparation method thereof. Background technique [0002] Orthopedic disease is one of the diseases with high morbidity, which seriously affects the quality of life of patients. Bone defects are common in orthopedic diseases. Traditional bone defect treatment methods include autologous bone graft, allogeneic bone graft, and artificial bone graft. Autologous bone is an ideal material for bone defect repair, but the bone harvesting process increases the trauma and pain of patients, and the source of bone supply is limited, making it difficult to shape; allogeneic bone has immune rejection, and can spread diseases or cause postoperative complications And other issues. Therefore, artificial bone materials have become the focus of research in the field of orthopedics. Compared with traditional implanted bone ...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/12A61L27/02A61L27/04A61L27/50A61L27/54A61L27/56A61L27/58
Inventor 张兴曹磊徐倩杨锐
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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