Rehmannia furan aldehyde derivatives having antioxidant activity, and preparation method and application thereof

A technology of rehmannia furan aldehyde and antioxidant activity, which is applied in the field of medicine to achieve the effects of facilitating pharmacological and clinical research, simple extraction and separation methods, and easy availability of raw materials

Active Publication Date: 2019-05-03
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, in the prior art, there is no report on extracting and separating rehmannia furan aldehyde derivatives from dried baobab fruit as raw materials. According to existing literature reports, Rehmannia glutinosa furan aldehyde mainly exists in

Method used

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  • Rehmannia furan aldehyde derivatives having antioxidant activity, and preparation method and application thereof
  • Rehmannia furan aldehyde derivatives having antioxidant activity, and preparation method and application thereof
  • Rehmannia furan aldehyde derivatives having antioxidant activity, and preparation method and application thereof

Examples

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Example Embodiment

[0040] Example 1

[0041] Using 1.0kg of dried baobab fruit as raw material, the material-liquid ratio of 1:8 (kg / L) was refluxed with 70% ethanol for three times, 1 hour each time, and concentrated to obtain 93g of extract-like ethanol extract, which was concentrated to obtain ethanol The extract was separated by AB-8 macroporous adsorption resin column (column length 150cm, diameter 15cm), using ethanol-water (volume content of ethanol 10%, 50%, 95%) gradient elution, flow rate: 5mL / min, The eluent dosage for each gradient is 5 times the column volume. The eluent of 50% ethanol is collected and then separated by semi-preparative high performance liquid chromatography (Agilent XDB-C18reversed-phase column-5μm, 250×10mm). Elute with water (volume ratio 33:67). When collecting the target eluate, detect by TLC, use chloroform-methanol with a volume ratio of 5:1 as the developing solvent, and collect washes with Rf values ​​of 0.4 and 0.25, respectively. The liquid was removed, the...

Example Embodiment

[0054] Example 2

[0055] Using 1.0 kg of dried baobab fruit as raw material, extract three times with 60% ethanol reflux at a material-to-liquid ratio of 1:10 (kg / L), 1 hour each time, and concentrate to obtain 75g of extractive ethanol extract, which will be concentrated to obtain ethanol The extract was separated by AB-8 macroporous adsorption resin column (column length 150cm, diameter 15cm, using ethanol-water (ethanol volume content 15%, 60%, 95%) gradient elution, flow rate: 7mL / min, The amount of eluent for each gradient is 6 times the column volume. The eluent of 60% ethanol is collected and then separated by semi-preparative high performance liquid chromatography (Agilent XDB-C18reversed-phase column-5μm, 250×10mm). Elute with water (volume ratio 33:67). When collecting the target eluate, detect by TLC, use chloroform-methanol with a volume ratio of 5:1 as the developing solvent, and collect washes with Rf values ​​of 0.4 and 0.25, respectively. The liquid was removed,...

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Abstract

The invention belongs to the technical field of medicines and particularly discloses rehmannia furan aldehyde derivatives having antioxidant activity, and a preparation method and an application thereof. The structures of the derivatives are represented as the formulae I and II. The method includes: 1) performing alcohol extraction and concentration successively on a raw material, dried fruits ofbaobab tree, to obtain a crude extract; 2) performing chromatography separation through a macroporous adsorptive resin column on the crude extract, performing gradient elution by ethanol-water, wherein the volume content of ethanol in an eluent is 10-95%, collecting the eluent, of which the volume content of ethanol is 40-60%, and performing high performance liquid chromatography separation. The prepared rehmannia furan aldehyde derivatives have novel structure, are safe and toxic-free, and have strong antioxidant activity, can be widely applied to preparation of anti-oxidizing medicines, andhas excellent application value.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a rehmannia furan aldehyde derivative, a preparation method and application thereof. Background technique [0002] The baobab tree (Adansonia digitata) is native to tropical Africa. In addition to Africa, baobab trees can also be seen in the Mediterranean Sea, the Atlantic Ocean, the islands of the Indian Ocean, and northern Australia. It is cultivated in a small amount in the tropical areas of Fujian, Guangdong, and Yunnan in China. The whole body of the baobab tree is full of medicine. Its fruit, leaves and bark can be used as medicine, which can reduce inflammation, reduce fever and treat malaria. Its fruit, leaves and bark can be used as medicine, which has the effects of nourishing the stomach and gallbladder, clearing heat and reducing swelling, stopping bleeding and diarrhea, and calming the nerves. Scientists decomposed a substance from baobab that can inhib...

Claims

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Application Information

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IPC IPC(8): C07D307/935A61K31/343A61P39/06
Inventor 李行诺颜继忠何德峰
Owner ZHEJIANG UNIV OF TECH
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