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Rehmannia furan aldehyde derivatives having antioxidant activity, and preparation method and application thereof

A technology of rehmannia furan aldehyde and antioxidant activity, which is applied in the field of medicine to achieve the effects of facilitating pharmacological and clinical research, simple extraction and separation methods, and easy availability of raw materials

Active Publication Date: 2019-05-03
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the prior art, there is no report on extracting and separating rehmannia furan aldehyde derivatives from dried baobab fruit as raw materials. According to existing literature reports, Rehmannia glutinosa furan aldehyde mainly exists in the traditional Chinese medicine Rehmannia glutinosa, which is a perennial herb, and fresh rehmannia glutinosa It is a medicine for clearing heat and cooling blood, while Rehmannia glutinosa is a tonic medicine, both of which have strong medicinal value.

Method used

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  • Rehmannia furan aldehyde derivatives having antioxidant activity, and preparation method and application thereof
  • Rehmannia furan aldehyde derivatives having antioxidant activity, and preparation method and application thereof
  • Rehmannia furan aldehyde derivatives having antioxidant activity, and preparation method and application thereof

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Embodiment 1

[0041] Using 1.0 kg of dried baobab fruit as raw material, according to the solid-liquid ratio of 1:8 (kg / L), reflux extraction with 70% ethanol three times, each time for 1 hour, concentrate to obtain 93 g of extract-like ethanol extract, and concentrate to obtain ethanol The extract was separated through an AB-8 macroporous adsorption resin column (column length 150cm, diameter 15cm), using ethanol-water (volume content of ethanol: 10%, 50%, 95%) for sequential gradient elution, flow rate: 5mL / min, The amount of eluent used for each gradient was 5 times the column volume, and the eluate of 50% ethanol was collected and then separated by semi-preparative high-performance liquid chromatography (Agilent XDB-C18 reversed-phase column-5μm, 250×10mm), separated by acetonitrile- Water (volume ratio 33:67) was used for elution, and when the target eluent was collected, it was detected by TLC, using chloroform-methanol with a volume ratio of 5:1 as the developing solvent, and the elue...

Embodiment 2

[0055] Using 1.0kg of dried baobab fruit as raw material, according to the solid-liquid ratio of 1:10 (kg / L), reflux extraction with 60% ethanol three times, each time for 1h, concentrate to obtain 75g of extract-like ethanol extract, and concentrate to obtain ethanol The extract was separated through an AB-8 macroporous adsorption resin column (column length 150cm, diameter 15cm), using ethanol-water (volume content of ethanol: 15%, 60%, 95%) for sequential gradient elution, flow rate: 7mL / min, The amount of eluent used for each gradient is 6 times the column volume, and the eluate of 60% ethanol is collected and then separated by semi-preparative high-performance liquid chromatography (Agilent XDB-C18 reversed-phase column-5μm, 250×10mm), separated by acetonitrile- Water (volume ratio 33:67) was used for elution, and when the target eluent was collected, it was detected by TLC, using chloroform-methanol with a volume ratio of 5:1 as the developing solvent, and the eluents wit...

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Abstract

The invention belongs to the technical field of medicines and particularly discloses rehmannia furan aldehyde derivatives having antioxidant activity, and a preparation method and an application thereof. The structures of the derivatives are represented as the formulae I and II. The method includes: 1) performing alcohol extraction and concentration successively on a raw material, dried fruits ofbaobab tree, to obtain a crude extract; 2) performing chromatography separation through a macroporous adsorptive resin column on the crude extract, performing gradient elution by ethanol-water, wherein the volume content of ethanol in an eluent is 10-95%, collecting the eluent, of which the volume content of ethanol is 40-60%, and performing high performance liquid chromatography separation. The prepared rehmannia furan aldehyde derivatives have novel structure, are safe and toxic-free, and have strong antioxidant activity, can be widely applied to preparation of anti-oxidizing medicines, andhas excellent application value.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a rehmannia furan aldehyde derivative, a preparation method and application thereof. Background technique [0002] The baobab tree (Adansonia digitata) is native to tropical Africa. In addition to Africa, baobab trees can also be seen in the Mediterranean Sea, the Atlantic Ocean, the islands of the Indian Ocean, and northern Australia. It is cultivated in a small amount in the tropical areas of Fujian, Guangdong, and Yunnan in China. The whole body of the baobab tree is full of medicine. Its fruit, leaves and bark can be used as medicine, which can reduce inflammation, reduce fever and treat malaria. Its fruit, leaves and bark can be used as medicine, which has the effects of nourishing the stomach and gallbladder, clearing heat and reducing swelling, stopping bleeding and diarrhea, and calming the nerves. Scientists decomposed a substance from baobab that can inhib...

Claims

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Application Information

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IPC IPC(8): C07D307/935A61K31/343A61P39/06
Inventor 李行诺颜继忠何德峰
Owner ZHEJIANG UNIV OF TECH
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