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Method for integrating polyurethane film on PDMS-based microfluidic structure

A microfluidic structure, integrated polyurethane technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve problems affecting the fineness and integrity of microstructures, unfavorable microfluidic chip preparation, complicated steps and other problems, to achieve the effect of low cost, good air tightness and outstanding elongation

Active Publication Date: 2019-05-07
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The bonding method has complicated steps and difficult operation, and the semi-cured PDMS will affect the fineness and integrity of the microstructure, which is not conducive to the preparation of microfluidic chips. Therefore, it is necessary to find a more reliable method to bond microfluidics based on PDMS integrated polyurethane film

Method used

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  • Method for integrating polyurethane film on PDMS-based microfluidic structure
  • Method for integrating polyurethane film on PDMS-based microfluidic structure
  • Method for integrating polyurethane film on PDMS-based microfluidic structure

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Embodiment 1

[0021] Such as Figure 1-5 As shown, this embodiment is based on the method of integrating a polyurethane film on a PDMS microfluidic structure, including the following steps:

[0022] (1) Take the PDMS-based microfluidic structure 101, clean it, dry it, and set it aside. The cleaning method is to clean it with isopropanol first, and then use deionized water to rinse the residual liquid on the surface. Blow dry with a nitrogen gun.

[0023] (2) Uniformly spin-coat the polyurethane dispersion on the silicon wafer, heat and solidify to form the polyurethane elastic film 102, wherein the polyurethane dispersion is an anionic water-based aliphatic polyurethane dispersion with a solid content greater than 35%.

[0024] (3) The microfluidic structure 101 and the polyurethane elastic film 102 processed in steps (1) and (2) are subjected to plasma treatment, wherein the plasma treatment method is to put the microfluidic structure 101 and the polyurethane elastic film 102 into Oxygen...

Embodiment 2

[0027] Such as Figure 1-5 As shown, this embodiment is based on the method of integrating a polyurethane film on a PDMS microfluidic structure, including the following steps:

[0028] (1) Take the PDMS-based microfluidic structure 101, clean it, dry it, and set it aside. The cleaning method is to clean it with isopropanol first, and then use deionized water to rinse the residual liquid on the surface. Blow dry with a nitrogen gun.

[0029] (2) Uniformly spin-coat the polyurethane dispersion on the silicon wafer, heat and solidify to form the polyurethane elastic film 102, wherein the polyurethane dispersion is an anionic water-based aliphatic polyurethane dispersion with a solid content greater than 35%.

[0030] (3) The microfluidic structure 101 and the polyurethane elastic film 102 processed in steps (1) and (2) are subjected to plasma treatment, wherein the plasma treatment method is to put the microfluidic structure 101 and the polyurethane elastic film 102 into Oxygen...

Embodiment 3

[0033] Such as Figure 1-5 As shown, this embodiment is based on the method of integrating a polyurethane film on a PDMS microfluidic structure, including the following steps:

[0034] (1) Take the PDMS-based microfluidic structure 101, clean it, dry it, and set it aside. The cleaning method is to clean it with isopropanol first, and then use deionized water to rinse the residual liquid on the surface. Blow dry with a nitrogen gun.

[0035] (2) Uniformly spin-coat the polyurethane dispersion on the silicon wafer, heat and solidify to form the polyurethane elastic film 102, wherein the polyurethane dispersion is an anionic water-based aliphatic polyurethane dispersion with a solid content greater than 35%.

[0036] (3) The microfluidic structure 101 and the polyurethane elastic film 102 processed in steps (1) and (2) are subjected to plasma treatment, wherein the plasma treatment method is to put the microfluidic structure 101 and the polyurethane elastic film 102 into Oxygen...

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Abstract

The invention discloses a method for integrating a polyurethane film on a PDMS-based microfluidic structure, which comprises the following steps: (1) taking the PDMS-based microfluidic structure, cleaning, blow drying for standby; (2) uniformly spin-coating a silicon wafer with a polyurethane dispersion, heating and solidifying to form a polyurethane elastic film; (3) performing oxygen plasma treatment on the microfluidic structure and the polyurethane elastic film treated in the steps (1) and (2); (4) aligning the plasma-treated microfluidic structure in the step (3) with the bonding surfaceof the polyurethane elastic film quickly, applying pressure and heating to integrate the polyurethane elastic film on the surface of the microfluidic structure. Compared with the prior art, the product of the invention has good airtightness, can be used for manufacturing a pneumatic membrane valve, can improve performance, and is worth popularizing.

Description

technical field [0001] The invention relates to a method for preparing a microfluidic structure, in particular to a method for integrating a polyurethane film on a PDMS microfluidic structure. Background technique [0002] Microfluidic chips are currently a hot field in the development of micro-total analysis systems. By integrating a chemical or biological laboratory on a chip, functions such as sample preparation, reaction, separation, cell culture, and sorting in the chemical and biological fields are realized. This technology requires less samples, short detection time, high sensitivity and low cost, and is widely used in scientific research, environmental protection, medicine, biochemistry and other fields. [0003] In the development of microfluidic technology, soft lithography technology based on polydimethylsiloxane (PDMS) has been widely used in the preparation of microfluidic chips. However, due to the gas permeability of PDMS, it is easy to use it to prepare pneum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 朱真孙治华李子煜
Owner SOUTHEAST UNIV
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