Dual-nucleus chiral amine-imine magnesium complex and preparation method and application thereof

A technology of amine imide magnesium and complexes, which is applied in the direction of magnesium organic compounds, can solve problems such as metal residues, and achieve the effects of low cost, high product yield, and controllable molecular weight

Inactive Publication Date: 2019-05-10
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, one problem that still needs to be solved is that there will inevitably be metal residues in the products made by metal complex catalysts, and it is almost impossible to completely remove these residues from the polymer, so low-toxic magnesium complexes Become a more promising catalyst, especially when the polymer is used in the field of biomedicine, this type of catalyst is more important

Method used

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  • Dual-nucleus chiral amine-imine magnesium complex and preparation method and application thereof
  • Dual-nucleus chiral amine-imine magnesium complex and preparation method and application thereof
  • Dual-nucleus chiral amine-imine magnesium complex and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0038]The structural formula of the ligand used is the above formula (A), where R is hydrogen, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.14 g of the ligand was dissolved in 25 mL of dry toluene, and added to Mg( n Bu) 2 In the reaction mixture with benzyl alcohol, after adding, the reaction liquid was naturally raised to room temperature, and then heated to 60 ° C for 3 hours. After the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried. Weighed to obtain 3.05 g of solid, the yield was 83.4%.

Embodiment 2

[0040] The structural formula of the ligand used is the above formula (A), where R is a methyl group, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.64 g of the ligand was dissolved in 25 mL of dry toluene, and added to Mg( n Bu) 2 and benzyl alcohol reaction mixture, after adding, the reaction liquid was naturally raised to room temperature, and then heated to 40 ° C for 10 hours, after the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried Weighed to obtain 3.33 g of solid, the yield was 84.5%.

Embodiment 3

[0042] The structural formula of the ligand used is the above formula (A), where R is ethyl, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.92 g of the ligand was dissolved in 30 mL of dry toluene, and added to Mg( n Bu) 2 In the reaction mixture with benzyl alcohol, after the addition, the reaction liquid was naturally raised to room temperature, and then heated to 50°C for 6 hours. After the reaction was completed, the solvent was vacuum-dried, and the residue was added to dry n-hexane to filter and washed with dry n-hexane. , the product was collected and dried and weighed to obtain 3.66 g of solid, with a yield of 86.6%.

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Abstract

The invention discloses dual-nucleus chiral amine-imine magnesium complex and a preparation method and application thereof. The dual-nucleus chiral amine-imine magnesium complex has a structural formula shown as formula I, which is shown in the description, wherein R is hydrogen, methyl group, ethyl group or isopropyl group. A dual-nucleus amine-imine catalyst herein is made by one-pot reaction ofa ligand, Mg(nBu)2 and benzyl alcohol; the preparation method is simple; the cost is low; the product yield is high; the compound, the catalyst, herein has variable structure; the metallic center magnesium can be coordinated with N,N atoms of the ligand to form the catalyst for ring-opening polymerization of cyclic lactones; the catalytic activity is high, stereoselectivity is good, no co-catalyst is required, the reaction speed is high, polymerization operation is simple, and the polymerization product has narrow molecular weight distribution, controllable molecular weight and high yield; the catalyst is widely applicable to ring-opening polymerization of cyclic lactones and is very ideal.

Description

technical field [0001] The invention relates to a dinuclear chiral amine imine magnesium complex and a preparation method thereof, and also relates to the application of the dinuclear chiral amine imine magnesium complex as a catalyst for ring-opening polymerization of cyclic lactones. Background technique [0002] With the enhancement of people's awareness of environmental protection, the development of degradable biomaterials that can reduce environmental pollution has become one of the important research fields of polymer materials. Polylactone is a biodegradable, green and environment-friendly polymer material, and it has attracted more and more attention as a substitute for petroleum products. In the natural living environment, waste polylactone materials can be completely decomposed into small molecules by microorganisms in the soil. Because polyester is non-toxic, non-irritating, and has good biocompatibility, it is widely used in medical and environmental protection...

Claims

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Application Information

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IPC IPC(8): C07F3/02C08G63/83C08G63/08
Inventor 顿爱社张春菊金旭王洪宾姚伟张海东于广福孙丰刚
Owner TAISHAN MEDICAL UNIV
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