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Method of utilizing dinuclear amine imine magnesium complex to catalyze lactide polymerization

A technology of dinuclear amine imine magnesium and complex is applied in the field of catalyzing lactide polymerization, can solve problems such as metal residue, and achieve the effects of low cost, high stereoselectivity and high product yield

Active Publication Date: 2019-05-14
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, one problem that still needs to be solved is that there will inevitably be metal residues in the products made by metal complex catalysts, and it is almost impossible to completely remove these residues from the polymer, so low-toxic magnesium complexes Become a more promising catalyst, especially when the polymer is used in the field of biomedicine, this type of catalyst is more important

Method used

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  • Method of utilizing dinuclear amine imine magnesium complex to catalyze lactide polymerization
  • Method of utilizing dinuclear amine imine magnesium complex to catalyze lactide polymerization
  • Method of utilizing dinuclear amine imine magnesium complex to catalyze lactide polymerization

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Experimental program
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Effect test

Embodiment 1

[0037]The structural formula of the ligand used is the above formula (A), where R is hydrogen, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.09 g of the ligand was dissolved in 20 mL of dry toluene, and added to Mg( n Bu) 2 In the reaction mixture with benzyl alcohol, after adding, the reaction liquid was naturally raised to room temperature, and then heated to 60 ° C for 3 hours. After the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried. Weighed to obtain 2.75 g of solid, yield 81.2%.

Embodiment 2

[0039] The structural formula of the ligand used is the above formula (A), where R is a methyl group, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.37 g of the ligand was dissolved in 20 mL of dry toluene, and added to Mg( n Bu) 2 and benzyl alcohol reaction mixture, after adding, the reaction liquid was naturally raised to room temperature, and then heated to 40 ° C for 12 hours, after the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried Weighed to obtain 3.27 g of solid, yield 89.1%.

Embodiment 3

[0041] The structural formula of the ligand used is the above formula (A), where R is ethyl, and the reaction process is as follows: under a nitrogen atmosphere, slowly add 5 mL of benzyl alcohol tetrahydrofuran solution (2.0 mol / L) to an equimolar amount of Mg( n Bu) 2 Hexane solution (2.0 mol / L, 5 mL) was reacted for 1 hour, 2.65 g of the ligand was dissolved in 30 mL of dry toluene, and added to Mg( n Bu) 2 In the reaction mixture with benzyl alcohol, after adding, the reaction liquid was naturally raised to room temperature, and then heated to 50 ° C for 4 hours. After the reaction was completed, the solvent was vacuum-dried, and the residue was washed with dry n-hexane, filtered, and then the product was collected and dried. Weighed to obtain 3.17 g of solid, yield 80.3%.

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Abstract

The invention discloses a method of utilizing dinuclear amine imine magnesium complex to catalyze lactide polymerization. The method includes: taking the dinuclear ammine imine magnesium complex as acatalyst and lactide as a raw material to catalyze lactide polymerization without water and oxygen and under gas protection to obtain polylactide. The dinuclear amine imine magnesium complex which isown-developed is taken as the catalyst for lactide ring-opening polymerization reaction, the catalyst is simple in preparation method, low in cost, diverse in structure and high in catalytic activity,three-dimensional selectivity and reaction rate, no cocatalyst is needed, and metal center magnesium is coordinated with N, N atoms of ligand, so that the catalyst is quite ideal. Polymer obtained byreaction is narrow in molecular weight distribution, controllable in molecular weight and high in yield and selectivity.

Description

technical field [0001] The invention relates to a method for catalyzing the polymerization of lactide, in particular to a method for catalyzing the polymerization of lactide by using a dinuclear amine imine magnesium complex. Background technique [0002] With the enhancement of people's awareness of environmental protection, the development of degradable biomaterials that can reduce environmental pollution has become one of the important research fields of polymer materials. Polylactone is a biodegradable, green and environment-friendly polymer material, and it has attracted more and more attention as a substitute for petroleum products. In the natural living environment, waste polylactone materials can be completely decomposed into small molecules by microorganisms in the soil. Because polyester is non-toxic, non-irritating, and has good biocompatibility, it is widely used in medical and environmental protection fields, such as surgical sutures, packaging, drug controlled...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/83C08G63/08
Inventor 王洪宾顿爱社孙丰刚张海东于广福姚伟游淇
Owner TAISHAN MEDICAL UNIV
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