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A kind of traditional Chinese medicine composition for treating tinea pedis and vulvovaginal candidiasis

A technology of vaginal candidiasis and composition, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, diseases, etc., and can solve the problems of drug-resistant skin, irritation, liver and kidney toxicity, etc.

Active Publication Date: 2022-07-22
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, oral and topical antifungal preparations are commonly used clinically, but oral fluconazole, itraconazole and other drugs have liver and kidney toxicity, and topical clotrimazole and nystatin are likely to cause drug resistance and local skin irritation symptoms

Method used

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  • A kind of traditional Chinese medicine composition for treating tinea pedis and vulvovaginal candidiasis
  • A kind of traditional Chinese medicine composition for treating tinea pedis and vulvovaginal candidiasis
  • A kind of traditional Chinese medicine composition for treating tinea pedis and vulvovaginal candidiasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0222] Example 1 (lotion):

[0223] 1. Prescription

[0224] 1900g cloves, 1500g patchouli, 2100g coptis, 1600g gentian, 1400g baibu, 300g alum, 1100g mint, 100g borneol (total 10kg).

[0225] 2. Preparation method

[0226] (1) take by weighing the crude drug according to the above-mentioned prescription, add water over 10 cm of the medicinal surface, soak for 1 hour and decoct 3 times;

[0227] (2) after boiling for the first time for 60 minutes, for the second time, for 45 minutes, after boiling for the third time, for 45 minutes, collecting decoction liquid respectively;

[0228] (3) merge the decoction, be concentrated to a concentrated solution with a relative density of 1.10 at 50-55°C, let it cool at room temperature, be 60% with 95% ethanol alcohol precipitation to an alcohol content, leave standstill for 48 hours, filter, and reclaim ethanol to Exhausted, concentrated into lotion to 10L (containing crude drug amount is 1g / mL);

[0229] (4) Refrigerated storage, an...

Embodiment 2

[0230] Example 2 (cream)

[0231] 1. Prescription

[0232] 2000g of cloves, 1600g of patchouli, 2000g of Coptis chinensis, 1500g of gentian, 1500g of Baibu, 300g of dry alum, 1000g of mint, 100g of borneol (total 10kg).

[0233] 2. Preparation method

[0234] (1) take by weighing the crude drug according to the above-mentioned prescription, add water over 10 cm of the medicinal surface, soak for 1 hour and decoct 3 times;

[0235] (2) after boiling for the first time for 60 minutes, for the second time, for 45 minutes, after boiling for the third time, for 45 minutes, collecting decoction liquid respectively;

[0236] (3) combined decoction, concentrated to a concentrated solution with a relative density of 1.10, allowed to cool at room temperature, precipitated to an alcohol content of 60% with 95% ethanol, left standstill for 48 hours, filtered, and recovered ethanol to the end;

[0237] (4) Add excipients and concentrate into cream (containing crude drug content of 4g / mL...

Embodiment 3

[0238] Example 3 (Suppository)

[0239] 1. Prescription

[0240] 2100g of cloves, 1700g of patchouli, 1900g of Coptis chinensis, 1400g of gentian, 1600g of Baibu, 200g of alum, 1000g of mint, 100g of borneol (total 10kg).

[0241] 2. Preparation method

[0242] (1) take by weighing the crude drug according to the proportion by weight of the prescription, add water over 10 cm of the medicinal surface, soak for 1 hour and decoct 3 times;

[0243] (2) after boiling for the first time for 60 minutes, for the second time, for 45 minutes, after boiling for the third time, for 45 minutes, collecting decoction liquid respectively;

[0244] (3) combined decoction, concentrated to a concentrated solution with a relative density of 1.10, allowed to cool at room temperature, precipitated to an alcohol content of 60% with 95% ethanol, left standstill for 48 hours, filtered, and recovered ethanol to the end;

[0245] (4) Add excipients and concentrate into extract (with crude drug conten...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating tinea pedis and vulvovaginal candidiasis. The traditional Chinese medicinal composition is composed of active ingredients and medically acceptable auxiliary materials, wherein the active ingredients are prepared from the following raw materials in parts by weight Aqueous extracts: 19-21 parts of cloves, 15-17 parts of patchouli, 19-21 parts of Coptis chinensis, 14-16 parts of gentian, 14-16 parts of 100 parts, 2-4 parts of kale, 9-11 parts of mint 0.5‑1.5 servings of borneol. The medicine of the present invention can be three kinds of external preparations of lotion, suppository or cream, and has the advantages of precise curative effect, rapid symptom relief and good safety through clinical verification.

Description

technical field [0001] The present invention relates to medical preparations, in particular to pharmaceutical preparations containing undetermined structures from plants. Background technique [0002] The diseases treated by the invention are mainly: tinea pedis and vulvovaginal candidiasis. [0003] Fungal diseases can be simply divided into superficial fungal diseases and deep fungal diseases according to the location of their invasion. Superficial mycosis mainly refers to infections caused by fungal invasion of the epidermis, mucous membranes, nails and hair. Superficial mycosis is one of the important diseases in dermatology, among which tinea pedis and vulvovaginal candidiasis are one of the most common clinical diseases. [0004] Tinea pedis is a fungal infection of the feet caused by dermatophytes, mainly involving the toes, interdigital and lateral margins, and in severe cases, the dorsum of the feet and ankles. The pathogenic bacteria of tinea pedis are mainly de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/904A61P17/00A61P31/10A61P15/02A61K33/06A61K31/045
Inventor 范瑞强陈信生袁娟娜谢婷袁小红莫冬冬
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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