IR780 double-targeted near-infrared fluorescent probe preparation method and application on tumor diagnosis and treatment
A 1. IR780, fluorescent probe technology, applied in the field of biomedicine, can solve the problems of poor diagnosis and treatment effect, single imaging and treatment mode, tumor insensitivity, etc., to improve the effect of lack of targeting
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[0051] The content of the present invention will be described in detail below in conjunction with specific embodiments. It should be noted that what is described below is an explanation rather than a limitation of the present invention.
[0052] 1. The preparation of the near-infrared fluorescent probe based on IR780 tumor dual targeting of the present invention.
[0053] The preparation of the near-infrared fluorescent probe based on IR780 tumor dual-targeting for single-molecule multifunctional diagnosis and treatment of the present invention mainly includes the following steps:
[0054] Step 1: Dissolve IR780 and 4-(aminoethyl)-morpholine in a ratio of 1:2 in 50-100 mL of anhydrous acetonitrile, and 2 Under air atmosphere, react at 50-80 degrees Celsius for 6-10 hours, and evaporate the solvent under reduced pressure after the reaction is cooled;
[0055] Step 2: Pass the product after the above-mentioned evaporation of the solvent through a silica gel column, and carry o...
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