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Medicine-lipiodol solvent and preparation method thereof

A technology of lipiodol and solvent, which is applied in the field of drug-iodol solvent and its preparation, and can solve problems such as unfavorable long-acting treatment, influence of lipiodol viscosity, unfavorable treatment, etc.

Inactive Publication Date: 2019-05-31
厦门宏谱福生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, no matter the drug-iodol suspension or emulsion is dispersed in lipiodol dispersion in the form of micron-sized large particles, it is easy to precipitate or layer after mixed drug injection and injection, which is not conducive to long-term treatment
Moreover, in TACE treatment, the high viscosity of iodized oil is mainly used to realize the filling and dispersion of iodized oil in the liver cancer area, and the addition of solvent or emulsion can affect the viscosity of iodized oil, which is not conducive to treatment.

Method used

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  • Medicine-lipiodol solvent and preparation method thereof
  • Medicine-lipiodol solvent and preparation method thereof
  • Medicine-lipiodol solvent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The preparation of doxorubicin-lipiodol solvent includes the following steps:

[0065] (a) First, take 5 mg of doxorubicin, add it to 2 mL of ethanol, and use an ultrasonic cleaner to sonicate for 5 min to make it evenly mixed;

[0066] (b) then, in the autoclave, add 2mL lipiodol injection;

[0067] (c) then, add 200 μL of doxorubicin ethanol solution to the autoclave;

[0068] (d) After sealing the autoclave, pressurize it to 10Mpa through the system, and control the temperature at 30°C. After the temperature and pressure are stable, turn on the stirring paddle to stir at 9000 rpm, maintain the temperature and pressure, and stir for 1 hour;

[0069] (e) Then slowly depressurize and collect doxorubicin-lipiodol solvent.

Embodiment 2

[0071] The preparation of indocyanine green-lipiodol solvent comprises the following steps:

[0072] (a) First, weigh 1 mg of indocyanine green, add it to 2 mL of ethanol, and use an ultrasonic cleaner to sonicate for 5 min to make it evenly mixed;

[0073] (b) then, in the autoclave, add 5mL lipiodol injection;

[0074] (c) then, add 150 μL of doxorubicin ethanol solution to the autoclave;

[0075] (d) After sealing the autoclave, pressurize it to 20Mpa through the system, and control the temperature at 40°C. After the temperature and pressure are stable, turn on the stirring paddle and stir at 8000 rpm), maintain the temperature and pressure stability, and stir for 2h;

[0076] (e) The pressure was then slowly reduced, and the indocyanine green-lipiodol solvent was collected.

Embodiment 3

[0078] The preparation of indocyanine green / doxorubicin-lipiodol solvent includes the following steps:

[0079] (a) First, weigh 0.75 mg of indocyanine green, 0.75 mg of doxorubicin and add it to 2 mL of ethanol, and use an ultrasonic cleaner to sonicate for 5 min to make it evenly mixed;

[0080] (b) then, in the autoclave, add 2.5mL lipiodol injection;

[0081] (c) Then, add 150 μL of indocyanine green / doxorubicin ethanol solution to the autoclave;

[0082] (d) After sealing the autoclave, pressurize it to 15Mpa through the system, and control the temperature at 50°C. After the temperature and pressure are stabilized, turn on the stirring paddle to stir at 12,000 rpm, maintain the temperature and pressure, and stir for 0.5h;

[0083] (e) The pressure was then slowly reduced, and the indocyanine green / doxorubicin-lipiodol solvent was collected.

[0084] like figure 1 As shown, the absorption curve of ICG molecules in IO@ICG changed, but the characteristic peaks of ICG rema...

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Abstract

The invention discloses a medicine-lipiodol solvent and a preparation method thereof. According to the invention, a lipiodol injection and medicine molecules are dissolved and fully mixed under rapidstirring by utilizing high pressure, and a small molecule medicine is dispersed in the lipiodol after pressure reduction to prepare the uniformly mixed medicine-lipiodol solvent. The prepared medicine-lipiodol solvent has controllable morphology, long-term stability, slow medicine release rate compared with a medicine-lipiodol mixed suspension and emulsion, and the medicine molecules do not significantly affect the physical and chemical properties such as the viscosity of lipiodol. The medicine-lipiodol solvent is first embolized by injection through the hepatic artery in the treatment of liver cancer, then, the medicine molecules in the medicine-lipiodol solvent can further exert a sustained-release therapeutic effect. The method provided by the invention is a good method for combined treatment of lipiodol embolism.

Description

technical field [0001] The invention discloses a medicine-lipiodol solvent and a preparation method thereof. Background technique [0002] Liver cancer is a common cancer in my country and Asia and Africa, with a high mortality rate. In the treatment of liver cancer, the first choice is surgery. However, liver cancer is often accompanied by liver cirrhosis, which limits surgical resection, and there is no way to perform surgical treatment in the treatment of intermediate and advanced liver cancer. Transarterial chemoembolization (TACE) is recognized as an important treatment method for liver cancer. At present, iodinated oil has become the most commonly used embolic agent for TACE due to its convenient injection and selective deposition. Liver cancer is mainly supplied by the hepatic artery, and normal liver tissue is supplied by the portal vein and hepatic artery. Through TACE treatment, lipiodol is deposited in liver sinusoids, interstitial spaces and even small blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/02
CPCA61K9/0019A61K9/10A61K47/44A61K51/1217
Inventor 刘刚楚成超朱靖张阳陈爱政陈标奇
Owner 厦门宏谱福生物科技有限公司
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