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Microfluidic alveolar chip based on chemical modification

A chemical modification, microfluidic technology, applied in chemical instruments and methods, biochemical cleaning devices, biochemical equipment and methods, etc. Product differences and other problems, to achieve the effect of fast detection, reduced cost and time, and less sample consumption

Inactive Publication Date: 2019-06-11
INST OF MICROELECTRONICS CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
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Problems solved by technology

However, although the conventional two-dimensional cell culture is simple and feasible, it is obviously different from the three-dimensional physiological growth phenomenon of lung cells in the alveolar structure containing the air-blood barrier in vivo, and the cell metabolites will also be different, which has certain limitations for complex analysis and research. sex
[0004] It can be seen that the metabolic activities of cells cultured in conventional two-dimensional media are quite different from those in vivo, and the respiratory detection products are inaccurate, and it is not easy to miniaturize and integrate

Method used

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  • Microfluidic alveolar chip based on chemical modification
  • Microfluidic alveolar chip based on chemical modification
  • Microfluidic alveolar chip based on chemical modification

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Embodiment Construction

[0017] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is only some embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0018] Here is a brief introduction to the concept of microfluidic chips. Microfluidic chips refer to the integration or basic integration of basic operating units such as sample preparation, reaction, separation, detection, cell culture, sorting, and lysis involved in the fields of chemistry and biology. On a chip of a few square centimeters...

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Abstract

The invention provides a microfluidic alveolar chip based on chemical modification. A human lung structure and a cell growth microenvironment can be simulated through a three-layer four-channel three-dimensional cell culture system formed on a chip, thereby more realistically restoring the cell growth environment in vivo. Therefore, cell metabolic gas can be detected more accurately. At the same time, the chemical modification of the chip can realize collection and detection of metabolic gas in vitro, a theoretical basis is provided for respiratory detection of lung diseases, and a new idea isprovided for treatment for diseases such as lung cancer.

Description

technical field [0001] The invention relates to the technical field of micro-nano processing, in particular to a microfluidic alveolar chip based on chemical modification. Background technique [0002] Breath detection is a qualitative and quantitative study of the detection of volatile organic compounds in breath. In recent years, it has received extensive attention in the fields of health diagnosis, bioinformatics and pharmaceuticals. Especially in the field of health diagnosis, due to its non-invasive, painless and easy collection characteristics, breath detection is increasingly used in routine physical examination and early diagnosis of diseases. Since any deviation in cell metabolism caused by abnormal gene expression will affect the composition and concentration of small molecule products in the blood, these small molecule metabolites dissolved in the blood will be transferred to the lungs and excreted by respiration. It can be seen that the composition of the exhale...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N33/50C12M3/00C12M1/34C12M1/00
Inventor 魏昕钰李明虓
Owner INST OF MICROELECTRONICS CHINESE ACAD OF SCI
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