Compound Oleraciamide E in Portulaca oleracea L. as well as extraction and separation method and application of compound Oleraciamide E

A separation method and the technology of purslane, applied in chemical instruments and methods, medical preparations containing active ingredients, sugar derivatives, etc., can solve the problem of low structural novelty, and achieve environmentally friendly process methods, simple and convenient operation methods and fast effect

Active Publication Date: 2019-06-18
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Compound Oleraciamide E in Portulaca oleracea L. as well as extraction and separation method and application of compound Oleraciamide E
  • Compound Oleraciamide E in Portulaca oleracea L. as well as extraction and separation method and application of compound Oleraciamide E
  • Compound Oleraciamide E in Portulaca oleracea L. as well as extraction and separation method and application of compound Oleraciamide E

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Embodiment Construction

[0030] The present invention provides new compound, molecular formula is C 22 h 25 NO 10 , named Oleraciamide E, the chemical structural formula is:

[0031] .

[0032] Described new compound is called Oleraciamide E according to structure, and table 1 is the NMR data of this new compound: 1 H-NMR with 13 C-NMR in DMSO.

[0033] Table 1 NMR data of the new compounds of the present invention.

[0034]

[0035] Oleraciamide E: yellow-green powder, easily soluble in methanol, slightly soluble in chloroform. After spotting the sample on the silica gel thin-layer plate, the spots of the test solution of potassium bismuth iodide were orange-yellow, suggesting that the compound is an alkaloid component. UV(MeOH)λ max : 310 nm. IR(KBr) v max 3382, 3256, 2920, 2849, 1607, 1514, 1490, 1443, 1389, 1175, 1028, 998, 831, 773cm -1 . HR-ESI(+)-TOF-MS gave m / z: 464.1547, [M+H] + The quasi-molecular ion peak, the molecular weight is 463.1478. combine 1 H-NMR, 13 Accordin...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicine, in particular to a new compound extracted, separated and identified from a Portulaca oleracea L. medicinal material as well as an extraction and separation method and an application of the new compound, and specifically provides a compound Oleraciamide E in Portulaca oleracea L. as well as the extraction and separation method and the application of the compound Oleraciamide E. The extraction and separation method of the new compound comprises steps as follows: water decoction extraction, ethyl acetate extraction, macroporous resin column chromatography, silica-gel column chromatography, ODS (Octadecylsilyl) medium-pressure column and Sephadex LH-20 purification and liquid-phase separation are adopted sequentially for preparation, and the compound is structurally determined to be a new alkaloid compound with UV, IR, HR-ESI-TOF-MS, <1>H-NMR, <13>C-NMR and two-dimensional magnetic resonance ectroscopy analysis methods. The compound has potential anti-inflammation and anti-tumor effects and other activity, and the new compound and salts or derivatives of the new compound can be taken as a raw material for primer synthesis from other compounds, new drug development and pharmacological activity research, and the primer and theoretical basis are provided for development of new drugs and new components.

Description

technical field [0001] The present invention relates to the field of extraction and separation of traditional Chinese medicine, in particular to a new compound extracted, separated and identified from purslane medicinal material and its extraction and separation method, specifically a compound Oleraciamide E in purslane and its extraction and separation method and application . Background technique [0002] purslane( Portulaca oleracea L.), also known as long-lived vegetable and horse amaranth, is a plant of the family Portulaca oleracea. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/08A61P35/00A61P29/00A61K31/7034
Inventor 英锡相刘锡龙张文洁徐纹顾莹莹段阳
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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