Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Amlodipine besylate tablets

A technology of amlodipine besylate tablets and amlodipine besylate, which is applied in the field of medicine, can solve the problem of affecting product yield, active ingredient content and dissolution rate, level to light, humidity, heat instability, and affecting products. Dissolution and other issues, to achieve the effect of improving content uniformity and dissolution, ensuring dissolution and high dissolution

Inactive Publication Date: 2019-07-02
HUNAN QIANJIN XIELI PHARMA CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the preparation process of amlodipine besylate tablets, there is a phenomenon that the raw materials are easily aggregated or adhered to the inner wall of the container due to electrostatic effects, thereby affecting the product yield and the content and dissolution rate of active ingredients.
Among the required raw materials, the main component amlodipine besylate is unstable to light, humidity and heat, and the auxiliary material anhydrous calcium hydrogen phosphate is heavy, while microcrystalline cellulose is light in texture, which makes it difficult to mix evenly. Thereby further affecting the dissolution rate of the product, resulting in a reduction in drug efficacy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Amlodipine besylate tablets
  • Amlodipine besylate tablets
  • Amlodipine besylate tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Amlodipine besylate sheet, is characterized in that, described amlodipine besylate sheet comprises the component of following percentage by weight:

[0042] Amlodipine besylate 2%-5%

[0043] Micropowder silica gel 0.1%-1%

[0044] Microcrystalline cellulose 55%-70%

[0045] Anhydrous calcium hydrogen phosphate 25%-35%,

[0046] Magnesium stearate 2%-4%,

[0047] Sodium carboxymethyl starch 0.1%-1%.

[0048] Amlodipine Besylate Tablet of the present invention comprises the following components by weight percentage:

[0049] Amlodipine Besylate 2.6%,

[0050] Micropowder silica gel 0.6%,

[0051] Microcrystalline Cellulose 65%,

[0052] Dicalcium Phosphate Anhydrous 30%,

[0053] Magnesium Stearate 3%,

[0054] Sodium carboxymethyl starch 0.6%

[0055] Amlodipine Besylate Tablet of the present invention comprises the following components by weight percentage:

[0056] Amlodipine Besylate 3.5%,

[0057] Micropowder silica gel 0.5%,

[0058] Microcrystalline C...

Embodiment 2

[0092] Amlodipine besylate sheet, the amlodipine besylate sheet comprises the following components by weight percentage:

[0093] Amlodipine Besylate 2.5%,

[0094] Micropowder silica gel 0.5%,

[0095] Microcrystalline Cellulose 62%,

[0096] Dicalcium Phosphate Anhydrous 32%,

[0097] Magnesium stearate 2% added,

[0098] Sodium carboxymethyl starch 0.5%,

[0099] Plus magnesium stearate 0.5%.

[0100] The preparation method of the amlodipine besylate sheet of the present embodiment may further comprise the steps:

[0101] (1) Take the raw and auxiliary materials in the above formula, first mix amlodipine besylate and micropowder silica gel evenly to obtain the mixed material A, and then pass through a 120-mesh sieve; then pass anhydrous calcium hydrogen phosphate through a 200-mesh sieve, microcrystalline Cellulose is passed through a 100-mesh sieve, sodium carboxymethyl starch and magnesium stearate are passed through a 80-mesh sieve;

[0102] (2) Dissolving microcr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to amlodipine besylate tablets. The amlodipine besylate tablets are mainly used for solving the technical problems that a conventional product is low in yield, poor in dissolution rate and the like. The technical scheme of the amlodipine besylate tablets is characterized in that the amlodipine besylate tablets comprise amlodipine besylate, micro powder silica gel, microlite cellulose, anhydrous calcium hydrogen phosphate, magnesium stearate and sodium carboxymethyl starch. The amlodipine besylate tablets are mainly used for the technical field of medicines.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to amlodipine besylate tablets and a preparation method thereof. Background technique [0002] Amlodipine besylate is a dihydropyridine calcium antagonist, which mainly inhibits the calcium storage capacity of the myocardial and vascular smooth muscle cell membranes and the ability to combine with calcium ions, and achieves the antihypertensive effect by dilating vascular arterioles and reducing peripheral resistance. [0003] In the preparation process of amlodipine besylate tablets, there is a phenomenon that the raw materials are easily aggregated or adhered to the inner wall of the container due to electrostatic effects, thereby affecting the product yield and the content and dissolution rate of active ingredients. Among the required raw materials, the main component amlodipine besylate is unstable to light, humidity and heat, and the auxiliary material anhydrous calcium hydro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4422A61K47/04A61K47/02A61K47/38A61K47/12A61P9/12
CPCA61K9/2009A61K9/2013A61K9/2054A61K9/2095A61K31/4422
Inventor 叶胜利
Owner HUNAN QIANJIN XIELI PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com