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Fluorescent probe based on aggregation-induced emission characteristics, method for determining critical micelle concentration by using fluorescent probe and application of fluorescent probe

A technology of aggregation-induced luminescence and critical micelle concentration, which is applied in the direction of luminescent materials, fluorescence/phosphorescence, chemical instruments and methods, etc., can solve the problems of complex operation, unfavorable detection, poor water solubility, etc., and achieve simple operation, simple preparation, and use convenient effect

Active Publication Date: 2019-07-19
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pyrene, a widely used fluorescent probe, has certain toxicity. Acute poisoning can cause symptoms such as convulsions and quadriplegia. It has poor water solubility.
In addition, the configuration of the pyrene fluorescent probe solution requires the use of flammable organic solvents, and the operation is complicated and time-consuming. It also requires the use of sophisticated instruments to measure the change in fluorescence intensity, which is not conducive to rapid and simple detection (Chem.Phys. Lett.,2012,547,110)

Method used

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  • Fluorescent probe based on aggregation-induced emission characteristics, method for determining critical micelle concentration by using fluorescent probe and application of fluorescent probe
  • Fluorescent probe based on aggregation-induced emission characteristics, method for determining critical micelle concentration by using fluorescent probe and application of fluorescent probe
  • Fluorescent probe based on aggregation-induced emission characteristics, method for determining critical micelle concentration by using fluorescent probe and application of fluorescent probe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Prepare AIE probe I with aqueous solution to a concentration of 2.5*10 -3 mol L -1 stock solution;

[0042] (2) Weigh 288.00 mg of anionic surfactant sodium dodecyl sulfate (SDS) (molecular weight 288) in a 100 mL volumetric flask, add double distilled water until the sample is dissolved, and use double distilled water to constant volume so that the concentration is 10mM SDS stock solution;

[0043] (3) At room temperature, take 4, 5, 6, 6.5, 7, 7.5, 8, 9, and 10 mL of the SDS stock solution prepared in (2) into nine 10 mL volumetric flasks, and add 0.1 mL of ( 1) The prepared AIE probe I stock solution was fixed to volume with double distilled water, and shaken evenly to obtain SDS sample solutions with concentrations of 4, 5, 6, 6.5, 7, 7.5, 8, 9, and 10 mM respectively;

[0044] (4) Measure the fluorescence emission spectrum (λ ex =415nm), the fluorescence intensity at the maximum emission wavelength is plotted against the corresponding SDS concentration, suc...

Embodiment 2

[0047] (1) Prepare AIE probe I with aqueous solution to a concentration of 2.5*10 -3 mol L -1 stock solution;

[0048] (2) Weigh 312.00mg of non-ionic surfactant fatty alcohol polyoxyethylene ether (AEO) (molecular weight 312) into a 100mL volumetric flask, add double distilled water until the sample is dissolved, and use double distilled water to constant volume, so that the concentration 10mM AEO stock solution;

[0049] (3) At room temperature, take 0.25, 0.5, 1, 1.2, 1.4, 1.6, 1.8, 2, 2.5mL of the AEO stock solution prepared in (2) into nine 10mL volumetric flasks, and add 0.1mL of (1) Prepare the AIE probe I stock solution, use double-distilled water to constant volume, shake well, so that AEO samples with concentrations of 0.25, 0.5, 1, 1.2, 1.4, 1.6, 1.8, 2, 2.5 mM are obtained liquid;

[0050] (4) Measure the fluorescence emission spectrum (λ ex =415nm), the fluorescence intensity at the maximum emission wavelength is plotted against the corresponding AEO concentr...

Embodiment 3

[0053] (1) Prepare AIE probe I with aqueous solution to a concentration of 2.5*10 -3 mol L -1 stock solution;

[0054] (2) Weigh 10 g of non-ionic surfactant Pluronic (F127) into a 100 mL volumetric flask, add double distilled water until the sample is dissolved, and use double distilled water for constant volume, so that a F127 stock solution with a concentration of 10 mg / mL is obtained ;

[0055] (3) At room temperature, take 5, 10, 20, 50, 100, 150, 200, 400, and 800 μL of the F127 stock solution prepared in (2) into nine 10mL volumetric flasks, and add 0.1mL of ( 1) For the prepared AIE probe I stock solution, use double-distilled water to make constant volume and shake well to obtain F127 with concentrations of 0.05, 0.1, 0.2, 0.5, 1.0, 1.5, 2.0, 4.0, and 8.0 mg / mL, respectively. sample liquid;

[0056] (4) Measure the fluorescence emission spectrum (λ ex =415nm), the fluorescence intensity at the maximum emission wavelength is plotted against the corresponding F127 ...

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Abstract

The invention provides a fluorescent probe based on aggregation-induced emission characteristics and a method for determining critical micelle concentration by using the fluorescent probe and application of the fluorescent probe. The aggregation-induced emission dye has a structure as shown in a formula I in the description. According to the invention, the fluorescent probe is innovatively appliedto the critical micelle concentration detection of a surfactant, and the approximate value can be rapidly determined. When the AIE fluorescent probe is used for detecting the critical micelle concentration of the surfactant, the operation steps are simple, the application range is wide, and the critical micelle concentration of an anionic surfactant and a nonionic surfactant can be accurately determined. In the formula I, R1 is independently selected from any one of C1-C8 carboxyl, a sulfonic group, a phosphate group or a phosphite group, and n is equal to 0, 1, 2, 3, 4, 5, 6 or 7; and R2 isindependently selected from any one of methyl, methoxy, N,N-dimethyl, N,N-dimethylaniline, triphenylamine, hydroxyl, amino or sulfydryl.

Description

technical field [0001] The invention belongs to the technical field of fine chemicals, and in particular relates to the application of a fluorescent probe based on aggregation-induced emission (AIE) characteristics to quickly and easily measure critical micelle concentration. Background technique [0002] Surfactants have various properties, such as wetting, emulsifying, foaming, dissolving, dispersing, washing, corrosion resistance, antistatic, etc., and are widely used in various fields, such as medicinal chemistry, synthetic chemistry, materials science, biology et al. (J. Am. Chem. Soc., 2009, 131, 1628; ACS Nano, 2012, 6, 1677). At a certain concentration, that is, critical micelle concentration (CMC), surfactants begin to form thermodynamically stable micelles, and at the same time, various properties change significantly. In addition, the CMC value will also be affected by various environmental factors, such as pH, solvent, temperature, inorganic salts and other fact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D215/12C07F9/60C09K11/06G01N21/64
CPCC07D215/12C07F9/60C09K11/06C09K2211/1007C09K2211/1029G01N21/6402G01N21/643
Inventor 朱为宏王琪郭志前李强刘振兴徐益升
Owner EAST CHINA UNIV OF SCI & TECH
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