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Copper selenide - noble metal heterostructure nanoprobes, and preparation method and application thereof

A heterostructure and nanoprobe technology, applied in the fields of material chemistry and biomedicine, can solve the problems of complex reaction conditions and difficult regulation, and achieve mild preparation conditions, broad market application prospects, broad surface modification and functionalization. Effect

Inactive Publication Date: 2019-07-23
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The Chinese patent application number 201410228420.5 discloses a Cu 2 The Se-Pd hybrid material and its preparation method need to be prepared in a high-temperature oil phase. The synthesized nanomaterials need to be stripped and phase-inverted into water-soluble nanomaterials before they can be used in biological experiments. The reaction conditions are complicated and difficult to control.

Method used

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  • Copper selenide - noble metal heterostructure nanoprobes, and preparation method and application thereof
  • Copper selenide - noble metal heterostructure nanoprobes, and preparation method and application thereof
  • Copper selenide - noble metal heterostructure nanoprobes, and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0062] (1) Disperse 160 mg of bovine serum albumin (BSA) in 16 mL of deionized water, and add it to a round bottom flask containing 55 mL of deionized water. Disperse 0.2 mmol of selenium dioxide in 1 mL of deionized water. Dissolve 1.2 mmol ascorbic acid in 3 mL water. Then, the selenium dioxide solution and the ascorbic acid solution were sequentially added to the round-bottomed flask, and the solution changed from colorless to wine red, and stirred at room temperature for 15 minutes.

[0063] (2) Dissolve 0.4 mmol copper sulfate pentahydrate and 1.6 mmol ascorbic acid in 5 mL of water, and then add to the reaction solution obtained in step (1), the solution turns from wine red to black, and the reaction is stirred at room temperature for 24 hours. After the reaction, the Cu 2- x Se (0≤x≤1) nanoparticles are separated by centrifugation to obtain nanoparticles with surface modification with BSA, with a particle size of about 20nm.

[0064] (3) Then to Cu 2-x Add a chloroplatinic...

Embodiment 2

[0070] Synthesize Cu according to the method in Example 1 2-x Se nanoparticles, do five sets of parallel experiments at the same time, and then add chloroplatinic acid solution to Cu according to the molar ratio Cu:Pt=1:0, 1:0.3, 1:0.6, 1:0.9, 1:1.2. 2-x In the Se nanoparticle solution, after 24 hours of reaction, centrifugal treatment to remove precipitation, Cu with different shell thickness can be obtained 2-x Se@Pt nanoparticles. The transmission electron microscope of nanoparticles obtained by adding different proportions of chloroplatinic acid is attached Figure 8 ,9,10,11,12 show that Cu with uniform size can be obtained in different proportions 2-x Se@Pt nanoparticles.

[0071] Different Cu:Pt ratio to Cu 2-x The influence of the core and shell of Se@Pt nanoparticles is attached Figure 13 As shown, it is possible to control the size of core and shell by adjusting different feeding ratios.

[0072] The hydrated particle size of the nanoparticles obtained under different Cu:...

Embodiment 3

[0077] The Cu obtained in Example 1 2-x Disperse Se nanoparticles into 30mL of aqueous solution, then add chloroauric acid aqueous solution with molar ratio Cu:Au=1:0.75, stir and react for 3 hours; after the reaction, the solution can be prepared for biocompatibility after multiple purification treatments Better stable dumbbell-shaped Cu 2-x Se-Au nanoparticles, as attached Figure 18 Shown.

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Abstract

The invention relates to a preparation method of copper selenide - noble metal heterostructure nanoprobes. The preparation method of the copper selenide - noble metal heterostructure nanoprobes comprises the following steps: dispersing copper selenide particles with stabilizer-modified surfaces in water so as to obtain an aqueous copper selenide solution, wherein the molecular formula of the copper selenide is Cu(2-x)Se (x is equal to 0 or above and equal to 1 or below), the particle size of the copper selenide particles is 1-100nm, and the stabilizer is water-soluble and bio-compatible sulfhydryl compounds or polyvinyl pyrrolidone with biological macromolecules or different molecular weights; and then, uniformly mixing the aqueous copper selenide solution with an aqueous noble metal saltsolution, and allowing reaction at 20-30 DEG C so as to obtain the copper selenide - noble metal heterostructure nanoprobes after completion of the reaction, wherein the mole ratio of copper elementsin the aqueous copper selenide solution to noble metal elements in the aqueous noble metal salt solution is 1 to 0.6-3.

Description

Technical field [0001] The invention relates to the fields of material chemistry and biomedicine, in particular to a copper selenide-noble metal heterostructure nano probe and its preparation and application. Background technique [0002] Cancer is the main cause of human death worldwide. Radiation therapy is one of the most important and effective ways to treat cancer. More than half of cancer patients will receive radiation therapy. Radiotherapy mainly uses high-energy rays (such as X-rays or gamma rays) to irradiate cancer tissues, and ROS directly or indirectly damages the DNA double-stranded structure of cells, leading to apoptosis and death of the irradiated cells. Due to the small difference in sensitivity between tumor tissues and normal tissues to radiation, radiation therapy can cause damage to normal tissues while treating tumor tissues. Therefore, how to improve the effect of radiotherapy and reduce the damage to normal tissues has become an important scientific iss...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/04A61P35/00
CPCA61K41/0038A61K41/0052A61K49/04A61P35/00A61K2300/00
Inventor 李桢周兴国黄倩
Owner SUZHOU UNIV
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