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Inactivation method of lenvatinib raw material production waste liquor

A technology for lenvatinib and raw materials, which is applied in the field of inactivation of lenvatinib raw drug production waste liquid, can solve the problems of inability to fundamentally solve the problem of wastewater treatment, unsatisfactory oxidant treatment effect, etc., and achieves low cost , the effect of mild conditions and simple inactivation process

Inactive Publication Date: 2019-08-02
HEZE UNIV
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Problems solved by technology

[0004] At present, the effect of treatment with oxidants (such as hydrogen peroxide, etc.) or strong alkali (such as sodium hydroxide, etc.) is not ideal
New treatment technologies include hydrolytic acidification-membrane bioreactor, anaerobic-aerobic bioreactor, medium-temperature upflow anaerobic sludge bed (UASB) reactor, high-activity anaerobic granular sludge industrial production technology, high-efficiency internal circulation Anaerobic reactor, which belongs to the improved technology of traditional biochemical process, has improved treatment efficiency, but it cannot fundamentally solve the problem of wastewater treatment of lenvatinib API

Method used

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  • Inactivation method of lenvatinib raw material production waste liquor
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  • Inactivation method of lenvatinib raw material production waste liquor

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Embodiment Construction

[0019] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. The embodiments described here are only some preferred implementation methods for further describing and illustrating the present invention, and are not intended to limit the present invention to the following specific details.

[0020] A kind of inactivation method of lenvatinib crude drug production waste liquid, the steps are as follows:

[0021] (1) Weigh 1000 mg of lenvatinib and dissolve it in 100 mL of tertiary water to prepare simulated waste liquid of lenvatinib raw material drug, and carry out liquid phase detection to obtain figure 2 ;

[0022] (2) Measure 10 mL of hydrochloric acid and add it to the simulated waste liquid of (1), and reflux and stir at 90~105°C for 8 h;

[0023] (3) After the reaction, the liquid phase detection of lenvatinib in the simulated waste liquid was carried out to obtain image 3 .

[0024] Dep...

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Abstract

The invention relates to an inactivation method, in particular to an inactivation method of lenvatinib raw material production waste liquor. The inactivation method comprises the following steps: (1)dissolving lenvatinib in water three times to prepare a lenvatinib raw material simulating waste liquor; (2) adding strong acid to the raw material simulating waste liquor in step (1), and performinga reflux stirring reaction at 90-105 DEG C for 6-10 h; (3) detecting lenvatinib in the raw material simulating waste liquor after the reaction in step (2). The related inactivation process is simple in process and mild in condition, the inactivation efficiency reaches 99.5%, hydrochloric acid cost used in inactivation is low in cost and easy to obtain, and the treatment problem of lenvatinib raw material wastewater is solved.

Description

technical field [0001] The invention relates to an inactivation method, in particular to an inactivation method for production waste liquid of lenvatinib bulk drug. Background technique [0002] Lenvatinib mesylate (LFTN), referred to as Lenvatinib, the chemical name is 4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6- Quinoline-formamide methanesulfonate, molecular formula C 22 h 23 ClN 4 o 7 S, structural formula see figure 1 , is a multi-target receptor tyrosine kinase inhibitor, which can block a series of regulatory factors in tumor cells including VEGFR1-3, FGFR1-4, PDGFRα, KIT, RET, and is a therapeutic agent for liver cancer. drug. [0003] However, the lenvatinib contained in the wastewater produced in the process of producing lenvatinib has a strong effect of killing microorganisms, which will invalidate the anaerobic and aerobic microorganisms required for biochemical treatment, resulting in "sewage treatment system "Paralyzed, unable to ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C02F1/00C02F101/34C02F101/38C02F103/36
CPCC02F1/00C02F2101/34C02F2101/38C02F2101/40C02F2103/36
Inventor 张凤荣武利顺王宪真汪涛韩丹丹牛正
Owner HEZE UNIV
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