Application of chlorophyll derivative chelated with transition metal in improvement of muscle microcirculation obstacle
A microcirculation disorder and transition metal technology, applied in the field of medicine, can solve problems such as easy stomach discomfort, limited user population, obvious toxic and side effects, etc., to prevent and improve muscle microcirculation disorder, safe for the applicable population, and simple process Effect
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Embodiment 1
[0060] Example 1 The protective effect of sodium copper chlorophyllin on muscle acute microcirculation disturbance
[0061] According to the above method, the content of sodium copper chlorophyllin is about 37.0%, and other chlorophyll derivatives are more than 60.0% based on disodium copper chlorophyllin. The effect on acute microcirculation disorder of rabbit muscles Tested and the results are as follows.
[0062] Table 1 Sodium copper chlorophyllin affects the rate of change of rabbit muscle microcirculation ( n=6)
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[0065] Note: Compared with the negative control group: *: P<0.05, **: P<0.01
[0066] Table 1 shows that, compared with the negative control group, the rate of change in blood perfusion (PU) and the degree of blood cell aggregation (CMBC) in the high-dose sodium copper chlorophyllin group were significantly reduced (P<0.01), and the rate of change in copper chlorophyllin was significantly lower (P<0.01). The other assessment indexes ...
Embodiment 2
[0067] Example 2 The protective effect of silkworm excrement extract on acute microcirculation disturbance
[0068] The experiment of Example 1 was repeated, except that the silkworm excrement whose weight percent content of sodium copper chlorophyllin was about 29.5% and other chlorophyll derivatives were more than 60.0% in terms of disodium copper chlorophyllin was used for the experiment. The results showed that blood perfusion (PU), blood cell aggregation (CMBC) and rate of change of exercise blood cell velocity (V) in the high and middle dose groups all decreased, indicating that the muscle microcirculation disorder of the tested rabbits was improved.
[0069] It can be seen from the above examples that the transition metal chelated chlorophyllin derivatives of the present invention, especially sodium copper chlorophyllin, can effectively improve or regulate blood perfusion, blood cell concentration and blood cell speed during exercise, thereby improving muscle Acute micr...
Embodiment 3
[0070] Embodiment 3 sodium copper chlorophyllin long-term toxicity test
[0071] Beagle dogs are orally administered with 1000, 500 and 250 mg of the above-mentioned silkworm excrement containing sodium copper chlorophyllin / kg, which is equivalent to 100, 50 and 25 times the maximum dosage of this product in clinical adult severe patients, once a day, once a week Rest for 1 day, continue administration for 180 days, and then recover from drug withdrawal for 30 days. Observing the symptoms of toxic reactions in Beagle dogs during the period of administration and drug withdrawal, and predicting the clinical adverse reactions that may be caused by the extract of silkworm excrement, the results show that: general observation, food intake, body weight, electrocardiogram, body temperature, blood pressure, ophthalmology, Urine, feces, blood, liver function, kidney function, bone marrow, system autopsy, organ index, histopathology and other aspects showed no significant difference or ...
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