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Antimicrobial preparations

A technology of bactericidal effect and preparation, applied in the medical field, can solve the problems of inability to directly interact with viruses and microorganisms, and low efficiency.

Active Publication Date: 2021-11-02
长春艾迪尔医用科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this drug is that it is administered by injection, it cannot directly act on viruses and microorganisms, and its efficiency is not high when dealing with combined infections

Method used

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  • Antimicrobial preparations
  • Antimicrobial preparations
  • Antimicrobial preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1. Synthetic Diffus antiviral peptide:

[0017] -HN 2 -His-gly-val-ser-gly-his-gly-gln-his-gly-val-his-gly-coOh (1)

[0018] As a temporary protecting group, a tert-butyloxycarbonyl group is used. A histidine and serine benzyl dinitrophenyl group were used as a permanent protected group. Synthesis is carried out on a benzoyl methyl polymer having a capacity of 0.8 mmol / g. As shown in Table 1, the peptide chain is gradually increased from the C end.

[0019] Table 1 Anti-adhesion procedure for amino acid residues

[0020]

[0021]

[0022] If the ninluol is detected, the cycle step is repeated from the third step.

[0023] After the synthesis of peptide-based polymers, 50% trifluoroacetic acid was treated with dichloromethane, and then washed with 5 ml of dichloromethane and removed from the container. It was rinsed with 5 ml of isopropyl alcohol and washed 5 ml of anhydrous ethyl ether three times. The obtained peptide-based polymer was dried in a vacuum dryer...

Embodiment 2

[0028] Synthetic synthetic peptide:

[0029] HN 2 - (CH 2 ) 10 -CO-ILE-LEU-PRO-D-PHE-LYS-D-Phe-PRO-D-PHE-D-Phe-PRO-D-Phe-Arg-Arg-NH 2 (2)

[0030] The synthesis, release, and cleaning methods of peptide (2) are the same as those of peptide 1. Protect nitro arginine N ω Function uses ε-amino groups of lysine, chloroformate group. In order to synthesize peptide in the reaction kettle, 10 ml of dimethylformamide was added to 0.2 g N-tert-butyl hydroxyl group-N ω Nitro-amanine methyl amphorne. The arginine derivative is 1 mmol / gram polymer.

[0031] After the polypeptide chain is completed, the protective peptide polymer is released while the polymer and the peptide are obtained using a liquid fluoride fluoride. The gradient of acetonitrile was purified at 0.1% trifluoroacetic acid during purification. Basic substance - peptide content HN 2 - (CH 2 ) 10 -CO-ILE-LEU-PRO-D-PHE-LYS-D-Phe-PRO-D-PHE-D-Phe-PRO-D-Phe-Arg-Arg-NH 2 - According to the optical density data, at least 99%. The a...

Embodiment 3

[0032]Example 3. Preparation of gels for skin and mucosal diseases.

[0033] Preparation of gels use chemical reactors and agitators. Put (polycarboxy) (1.5-2.0%) distilled water, NaOH solution (1.5-2.0%)), which was continued for 30 minutes. Then, the pH 6 was adjusted to pH 6, stirred, and the aqueous solution containing a preservative was injected, and methyl hydroxybenzoate (0.01-0.2% by mass) and hydroxybenzate (0002-0.01) were used as preservative. quality%). After the mixture was produced, 1.5-2.5% by mass of glycerol was added. Then it is stirred for 10 minutes and the pH is measured. The gel was then placed once a day, then retransmit, and evenly bracket in the container (tube). Thus, a gel having a homogeneous transparent and abutment of foreign particles is obtained. The gel component (mass%) is as follows: peptide -0, 02-0, 2; excipients - 99, 98-99, 8. Characteristics of peptid gel formulations are shown in Table 3.

[0034] Table 3 Components with peptide gel product...

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Abstract

The present invention provides a preparation, which relates to the field of medicine, that is, the new pharmaceutical composition has bactericidal, especially, antibacterial and antiviral effects. A preparation of the present invention, containing blowfly antiviral peptide similar drug peptide H 2 N‑His‑Gly‑Val‑Ser‑Gly‑His‑Gly‑Gln‑His‑Gly‑Val‑His‑Gly‑COOH– and peptide HN 2 -(CH 2 ) 10 ‑CO‑Ile‑Leu‑Pro‑D‑Phe‑Lys‑D‑Phe‑Pro‑D‑Phe‑D‑Phe‑Pro‑D‑Phe‑Arg‑Arg‑NH 2 The mass ratio is 1:2 to 2:1 and auxiliary materials. In summary, the preparation has comprehensive antibacterial and antiviral effects, and the preparation (injection, gel, ointment, spray, etc.) can be used to treat herpes virus infection, vaginal herpes infection, HPV virus infection, and bacterial infection.

Description

Technical field [0001] The present invention relates to the field of medical field, in particular a new pharmaceutical composition having sterilization, antibacterial and antiviral effects. Background technique [0002] According to WHO statistics, about 80% of the world infected different types of herpes simplex virus (HSV). One of the most serious and social significance caused by HSV is the genital herpes, mainly caused by HSV2 viruses. According to the 2015 data, the number of patients who have been infected with HSV-2 viruses at the age of 15 and 50 years old is 400 million. The herpes sex lesion not only reduces the quality of life, but also destroys the barrier function of epithelial cells, and adds the risk of HIV infection with other pathogens (Freeman Eeet Al., AIDS.2006, Jan 2; 20 ( 1): 73-83; Freedman E., Mindel A., J. Hiv Therm, 2004, Feb; 9 (1): 4-8). Study found that natural kill cells (NK cells) inhibit HSV activity The process plays a very important role. If it i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K38/10A61P31/00A61P31/22
CPCA61K9/0014A61K9/06A61K47/32A61K38/08A61K38/10A61P31/22C07K7/06A61P31/00
Inventor 伊丽娜·瓦西里耶夫娜·奥法妮娜亚历山大·亚历山大洛维奇·克罗巴福尼古拉·伊凡诺维奇·卡罗特金玛利亚·帕夫洛夫娜·斯米尔诺娃柳特米拉·伊凡诺夫娜·斯杰法尼卡
Owner 长春艾迪尔医用科技发展有限公司
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